Smoking is associated with an increased risk of first and recurrent ventricular tachyarrhythmias in ischemic and nonischemic patients with mild heart failure: A MADIT-CRT substudy

Plank, Benjamin; Kutyifa, Valentina; Moss, Arthur J.; Huang, David T.; Ruwald, Anne‐Christine; McNitt, Scott; Polonsky, Bronislava; Zaręba, Wojciech; Goldenberg, Ilan; Aktaş, Mehmet K.

doi:10.1016/j.hrthm.2014.02.007

Cited by 11 publications

(7 citation statements)

References 22 publications

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“…Plank et al [32] investigated in a sub-study of the Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy (MADIT-CRT-trial) the risk of first and recurrent ventricular tachyarrhythmias in patients with mild HF and ICD therapy according to smoking [32]. The study compared 465 non-smokers, 780 past smokers and 197 current smokers with ischemic and non-ischemic cardiomyopathy [32]. Current smokers with mild HF were shown to be associated with higher risk of ventricular tachyarrhythmias compared to past-and non-smokers [32].…”

Section: Discussionmentioning

confidence: 99%

“…The study compared 465 non-smokers, 780 past smokers and 197 current smokers with ischemic and non-ischemic cardiomyopathy [32]. Current smokers with mild HF were shown to be associated with higher risk of ventricular tachyarrhythmias compared to past-and non-smokers [32]. The MADIT-II trial showed that the risk of ventricular tachyarrhythmias in patients with CAD-related HF is higher in current smokers compared to past-and non-smokers.…”

Section: Discussionmentioning

confidence: 99%

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Risk factor paradox: No prognostic impact of arterial hypertension and smoking in patients with ventricular tachyarrhythmias

et al. 2020

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Background: Data regarding the outcome of patients with ventricular tachyarrhythmias related to arterial hypertension (AHT) and smoking is limited. The study sought to assess the prognostic impact of AHT and smoking on survival in patients presenting with ventricular tachyarrhythmias. Methods: All consecutive patients surviving ventricular tachycardia (VT) and ventricular fibrillation (VF) upon admission to the University Medical Center Mannheim (UMM), Germany from 2002 to 2016 were included and stratified according to AHT and smoking by propensity score matching. The primary prognostic endpoint was all-cause mortality at 30 months. Results: A total of 988 AHT-matched patients (494 each, with and without AHT) and a total of 872 smoking-matched patients (436 each, with and without smoking) were included. The rates of VT and VF were similar in both groups (VT: AHT 60% vs. no AHT 60%; smokers 61% vs. non-smokers 62%; VF: AHT 35% vs. no AHT 38%; smokers 39% vs. non-smokers 38%). Neither AHT nor smoking were associated with the primary endpoint of long-term all-cause mortality at 30 months (long-term mortality rates: AHT/no AHT, 26% vs. 28%; log-rank p = 0.525; smoking/non-smoking, 22% vs. 25%; log-rank p = 0.683). Conclusions: Paradoxically, neither AHT nor smoking were associated with differences of long-term all-cause mortality in patients presenting with ventricular tachyarrhythmias.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Risk factor paradox: No prognostic impact of arterial hypertension and smoking in patients with ventricular tachyarrhythmias

et al. 2020

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“…99 In rats, smoking leads to ventricular dilatation in both systole and diastole, which results in LV dysfunction. 77 14.14 PERIPHERAL VASCULAR DISEASE, SUDDEN CARDIAC DEATH, AND SMOKING Cigarette (tobacco) smoking has a significant association with peripheral vascular disease (PVD), as consistently proved in many large studies. 100 There was a significantly increased risk of ventricular tachycardia in patients with LV dysfunction as observed in the Multicenter Automatic Defibrillator Implantation TrialÀCardiac Resynchronization Therapy (MADIT-CRT) study, which was carried out across the patients with both ischemic and nonischemic cardiomyopathy.…”

Section: Smoking and Heart Failure/cardiomyopathymentioning

confidence: 94%

The Effects of Active and Passive Smoking and Cardiovascular Disease

2015

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“…Smoking and its disastrous effect on the cardiac muscle and its role in developing cardiac cachexia in CHF patients were discussed also by many studies in the literature (Ebner et al, 2013;Flouris et al, 2014;Plank et al, 2014). Flouris (2014) and his colleagues studied the effect of second hand smoking on 19 healthy nonsmokers adults and they measured Heart Rate Variability (HRV), serum cotinine, and six cardiac markers that include: Troponin I, Myoglobin, Creatine Kinase-MB (CK-MB), Carbonic Anhydrase III, Fatty Acid Binding Protein, and Glycogen Phosphorylase BB in serum samples.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Correlates of Cardiac Cachexia among Jordanian Patients with Chronic Heart Failure

Hweidi¹,

Alomari²

2018

GJHS

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Background: Cardiac cachexia is considered as an ominous complication that possibly associated with the terminal stages of chronic heart failure as it consumes the protein-calories reserves of the patients. Aims:The aims of this study were to identify the prevalence, level, and correlates of cardiac cachexia among Jordanian patients with chronic heart failure. Methods:A cross-sectional design was employed. A convenient sample of 300 chronic heart failure patients was recruited from accessible chronic heart failure patients who regularly visit the cardiac care clinics at two different hospitals that represent two health sectors in Jordan. A self-developed instrument was used to collect the data for the purpose of this study. Results:The mean of the total cachexia score of the sample was 5.88. Cardiac cachexia was detected in 58.7% (n= 176) about half of them were having mild cachexia. The prevalence of cardiac cachexia was 13.15%. There were statistically significant correlation between the total cachexia score and some variables that include the patients' age, monthly income, and number of years since diagnosed as chronic heart failure patients; however, number of daily smoked cigarettes wasn't significantly correlated with the total cachexia score. Conclusion:Cardiac cachexia has not been widely investigated yet. The findings of this study can be used as a baseline data since this study is the first of its kind conducted at the national and regional level. In addition, this study can be useful for determining effective therapeutic modalities that can be employed on behalf of those patients among the health care team; particularly nurses.

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Smoking is associated with an increased risk of first and recurrent ventricular tachyarrhythmias in ischemic and nonischemic patients with mild heart failure: A MADIT-CRT substudy

Cited by 11 publications

References 22 publications

Risk factor paradox: No prognostic impact of arterial hypertension and smoking in patients with ventricular tachyarrhythmias

Risk factor paradox: No prognostic impact of arterial hypertension and smoking in patients with ventricular tachyarrhythmias

The Effects of Active and Passive Smoking and Cardiovascular Disease

Prevalence and Correlates of Cardiac Cachexia among Jordanian Patients with Chronic Heart Failure

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