D27. Cellular Responses Informing Lung Repair 2020
DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6397
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Abstract: Rationale. Club cells, a small airway epithelium (SAE) secretory cell that expresses SCGB1A1 but not KRT5 (basal cell marker) or MUC5AC (goblet cell marker), play a central role in host defense of the human lung. In healthy, non-smoker SAE, club cell differentiation begins with basal stem/progenitor cells and proceeds through an intermediate cell phase before arriving at the mature club cell. In addition to their role in expressing host defense genes, club cells give rise to MUC5AC-positive goblet cells. Based… Show more

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