Smoking Alters Inflammation and Skeletal Stem and Progenitor Cell Activity During Fracture Healing in Different Murine Strains

Hao, Zichen; Li, Jun; Li, Bo; Alder, Kareme D.; Cahill, Sean V.; Munger, Alana M.; Lee, Inkyu; Kwon, Hyuk‐Kwon; Back, Jungho; Xu, Shuogui; Kang, Min; Lee, Francis Y.

doi:10.1002/jbmr.4175

Cited by 16 publications

(19 citation statements)

References 58 publications

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“…Furthermore, the authors observed a significant increase in pro-inflammatory mediators and immune cell recruitment in fracture hematomas in the mice exposed to smoke. These results show the important cellular and molecular disorders that occur during fracture healing due to smoking, such as abnormal chondrogenesis, aberrant activity of skeletal stem and progenitor cells, and an intense initial inflammatory response [ 74 ]. Table 3 shows the main factors that induce and delay bone healing according to recent publications on the molecular mechanisms of bone healing.…”

Section: Factors That Delay Bone Healingmentioning

confidence: 99%

A Review of Recent Developments in the Molecular Mechanisms of Bone Healing

Rodríguez-Merchán

2021

IJMS

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Between 5 and 10 percent of fractures do not heal, a condition known as nonunion. In clinical practice, stable fracture fixation associated with autologous iliac crest bone graft placement is the gold standard for treatment. However, some recalcitrant nonunions do not resolve satisfactorily with this technique. For these cases, biological alternatives are sought based on the molecular mechanisms of bone healing, whose most recent findings are reviewed in this article. The pro-osteogenic efficacy of morin (a pale yellow crystalline flavonoid pigment found in old fustic and osage orange trees) has recently been reported, and the combined use of bone morphogenetic protein-9 (BMP9) and leptin might improve fracture healing. Inhibition with methyl-piperidino-pyrazole of estrogen receptor alpha signaling delays bone regeneration. Smoking causes a chondrogenic disorder, aberrant activity of the skeleton’s stem and progenitor cells, and an intense initial inflammatory response. Smoking cessation 4 weeks before surgery is therefore highly recommended. The delay in fracture consolidation in diabetic animals is related to BMP6 deficiency (35 kDa). The combination of bioceramics and expanded autologous human mesenchymal stem cells from bone marrow is a new and encouraging alternative for treating recalcitrant nonunions.

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Section: Factors That Delay Bone Healingmentioning

confidence: 99%

A Review of Recent Developments in the Molecular Mechanisms of Bone Healing

Rodríguez-Merchán

2021

IJMS

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“…In vivo experiment, a custom-made chamber with airflow for rats to inhale cigarette smoke continuously, was established by Chang et al, and it was found that cigarette smoke inhibited early angiogenesis using a femoral osteotomy model, analyzed by radiograph and micro-CT imaging and various biomechanical and biological tests [36]. Other experiments have also demonstrated that tobacco accelerated the pronounced initial inflammatory response [37], suppressed the immune system [38] and increased infection incidence.…”

Section: Discussionmentioning

confidence: 99%

Impact of Smoking on the Incidence and Postoperative Complications of Total Knee Arthroplasty: A Systematic Review and Meta-Analysis of Cohort Studies

Omar

Feng

et al. 2021

Bosn J of Basic Med Sci

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Osteoarthritis and rheumatoid arthritis are the most ubiquitous joint disorders which cause tremendous loss of life quality and impose an economic burden on society. At present, the treatment options for these two diseases comprise non-operative and surgical treatments, amongst those total knee arthroplasties (TKA). Various studies have recognized smoking as a significant risk factor for postoperative complications. Therefore, the purpose of this study was to examine the impact of smoking on the incidence and postoperative complications after a total knee arthroplasty by a systematic review and meta-analysis. The research was performed using PUBMED, Cochrane Library and EMBASE, extracting data from thirteen suitable studies and incorporating 2,109,482 patients. Cohort studies evaluating the impact of smoking on TKA with sufficient data were included for the study, and cohort studies without a proper control group and complete data were excluded. A fixed-effects or random-effects model was used to measure the pooled risk ratio (RR) or hazard ratio (HR) with 95% confidence interval (CI). Compared to non-smokers, smokers had a significantly lower incidence of TKA (p<0.01). However, smokers had a higher incidence of total complications (p=0.01), surgical complications (p<0.01), pneumonia (p<0.01) and revision surgery (p=0.01). No significant difference in the risk of blood transfusion (p=0.42), deep vein thrombosis (p=0.31), pulmonary embolism (p=0.34), urinary tract infection (p=0.46) or mortality (p=0.39) was found between smokers and non-smokers. In conclusion, the study indicated that tobacco has two diametrically opposite effects on TKA patients: 1. Tobacco increases the incidence of surgical complications, pneumonia and revision after TKA; 2. It decreases the overall risk of being a candidate for TKA.

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“…26 In addition, a study conducted by Hao in 2021 in the United States showed a mean IL-1 of 100 pq/L and a median value of 80 pq/L. 27 This difference may be due to differences in the area of the wound that became the subject of each study. 25,26,27 IL-1 is known to regulate bone resorption and formation.…”

Section: Discussionmentioning

confidence: 99%

“…27 This difference may be due to differences in the area of the wound that became the subject of each study. 25,26,27 IL-1 is known to regulate bone resorption and formation. However, the results of different studies on (TNF-a), prostaglandin E2, and nitric oxide.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, marker analysis in hematoma 24 hours after femoral osteotomy showed that it was still high. IL-1, IL-6, IL-12p40, IFN-γ, IP-10, TNF-, KC, MCP-1 and macrophage inflammatory proteins are known proinflammatory mediators that regulate migration, infiltration, and function of different immune cells in acute inflammatory phase of fracture healing 27. Fracture healing occurs in four distinct phases:(1) inflammation, (2) soft callus, (3) hard callus, and (4) remodeling.…”

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confidence: 99%

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Comparison of Interleukin-1β Levels In Open and Closed Fracture Patients of The Long Bone In Padang

Arnif

Sahputra

Maska

2021

bsm

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Background and Purpose. Trauma is a significant burden on causes of death, disability, and financing in least developed or "third world" countries. Fracture healing, especially in wounds and tissues, begins with a hemostatic and inflammatory phase triggered by inflammatory mediators such as cytokines, particularly IL-1β and TNF-. The purpose of this study was to determine the difference in levels of interleukin-1β in open and closed fractures of long bones in PadangMethod. This type of research is analytic observational with cross sectional design with primary data. The data were taken from the examination of IL-1β levels in long bone fracture patients at RSUP Dr. M. Djamil, RSKB Ropanasuro and RST Reksodiwiryo Padang for 4 months starting from March 2021 to July 2021. The sampling technique in this study used non-probability sampling with the consecutive sampling method. The analysis was carried out using the Independent sample T-Test to see the difference in mean IL-1 which would be calculated for open fractures and closed fractures of long bones.Results. The results showed that most (92.9%) of the patients were male, 50% had open fractures, and 50% closed fractures. The mean value of the patient's age was 34 years and the mean level of IL-1β was 555,951 pq/L. Most of the fracture sites in patients were tibia and fibula (35.7%) and femur (35.7%) and 28.6% were radius and ulna. The results showed that there was a significant difference in the mean levels of IL-1β in patients with open and closed fractures of long bones (p-value = 0.007)Conclusion. There are differences in the levels of interleukin-1β in open and closed fractures of long bones in Padang. This research is expected to provide consideration to support examinations in health services, in this case in fracture patients

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Smoking Alters Inflammation and Skeletal Stem and Progenitor Cell Activity During Fracture Healing in Different Murine Strains

Cited by 16 publications

References 58 publications

A Review of Recent Developments in the Molecular Mechanisms of Bone Healing

A Review of Recent Developments in the Molecular Mechanisms of Bone Healing

Impact of Smoking on the Incidence and Postoperative Complications of Total Knee Arthroplasty: A Systematic Review and Meta-Analysis of Cohort Studies

Comparison of Interleukin-1β Levels In Open and Closed Fracture Patients of The Long Bone In Padang

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