Small RNAs in spermatogenesis

Yadav, Ram Prakash; Kotaja, Noora

doi:10.1016/j.mce.2013.04.015

Cited by 115 publications

(105 citation statements)

References 113 publications

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“…The piRNAs that map to retrotransposons have been shown to engage a 'ping-pong' amplification loop to suppress retrotransposon activity (Gan et al 2011). Previous reviews (Klattenhoff & Theurkauf 2008, Yadav & Kotaja 2014 indicated that piRNAs play an essential role in the maintenance of DNA integrity in germline cells.…”

Section: Introductionmentioning

confidence: 99%

MOV10L1 in piRNA processing and gene silencing of retrotransposons during spermatogenesis

Zhu

Zhi

2015

Reproduction

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Piwi-interacting RNAs (piRNAs) are a broad group of non-coding small RNAs with important biological functions in germline cells. It is well known that piRNAs can maintain genome integrity via silencing retrotransposons. Previous studies on the animal models harboring gene deletions have shown that the genes involved in piRNA biogenesis and their defective expression can result in the spermatogenic dysfunction. In the past decade, significant progress has been achieved for piRNAs and their roles in male germ cells. This review addresses the advances on piRNAs and piRNA biogenesis-associated genes, with a particular focus on the Moloney leukemia virus 10-like 1 (MOV10L1) gene, whose role in primary piRNA processing and in the 'ping-pong' cycle during secondary piRNA processing has been illustrated. The biological characteristics of piRNA has been summarized, and emphasis was laid on the roles of MOV10L1 in the mediation of piRNA biogenesis and retrotransposons silencing by DNA methylation. Furthermore, the association between MOV10L1 gene polymorphisms and complete maturation arrest in men has been discussed. Hence, thorough literature review was conducted in order to obtain a greater understanding of the function of MOV10L1 and its mechanisms underlying spermatogenesis in mice and humans. Free Chinese abstract: A Chinese translation of this abstract is freely available at

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Section: Introductionmentioning

confidence: 99%

MOV10L1 in piRNA processing and gene silencing of retrotransposons during spermatogenesis

Zhu

Zhi

2015

Reproduction

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“…Numerous studies have found associations between piRNA biogenesis-related genes and fertility [11,12]. However, the exact functional mechanism of Piwi/ piRNA complexes remains unclear.…”

Section: Discussionmentioning

confidence: 99%

“…To date, however, the molecular mechanisms that mediate piRNA-induced DNA methylation remain unclear. Previous reviews [11,12] have indicated that piRNAs play an essential role in maintaining DNA integrity in germline cells.…”

Section: Introductionmentioning

confidence: 99%

Association of a TDRD1 variant with spermatogenic failure susceptibility in the Han Chinese

Zhu

Zhi

et al. 2016

J Assist Reprod Genet

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Purpose Piwi-interacting RNAs (piRNAs) are a broad group of noncoding small RNAs that have important biological functions in germline cells and can maintain genome integrity via silencing of retrotransposons. In this study, we aimed to explore the associations between genetic variants of important genes involved in piRNA biogenesis and male infertility with spermatogenic impairment. Methods To this end, five single-nucleotide polymorphisms (SNPs) in the ASZ1, PIWIL1, TDRD1, and TDRD9 genes were genotyped by TaqMan allelic discrimination assays in 342 cases of nonobstructive azoospermia (NOA) and 493 controls. Results The SNP rs77559927 in TDRD1 was associated with a reduced risk of spermatogenic impairment. The genotypes TC and TC + CC showed odds ratios and 95 % confidence intervals of 0.73 (0.55-0.98, P = 0.034) and 0.73 (0.56-0.97, P = 0.030), respectively, in patients with NOA compared with those in the controls. Conclusion Thus, our results provided the first epidemiological evidence supporting the involvement of TDRD1 genetic polymorphisms in piRNA processing genes in determining the risk of spermatogenic impairment in a Han Chinese population.

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“…Application of short RNAs has contributed significantly in biology and medicine in recent years. Short ncRNAs involved in spermatogenesis have been systematically reviewed previously (Bettegowda & Wilkinson 2010, Chuma & Nakano 2013, Yadav & Kotaja 2014 and have proved to be indispensible in various developmental processes in male germ cell development.…”

Section: Noncoding Rnas: Overlooked Transcript Species In Genome Biologymentioning

confidence: 99%

“…Many lncRNAs are transcribed by RNA polymerase II just as a mRNA without protein coding ability, or formed by processing other transcripts. While short RNA relies largely on partnership with protein, such as argonaut (Yadav & Kotaja 2014) and piwi proteins (Chuma & Nakano 2013), for regulatory functions, there is no specific group of protein regulator identified for universal processing of lncRNA transcripts.…”

Section: A Novel Regulatory Layer In Cellular Development: Lncrnasmentioning

confidence: 99%

Long noncoding RNAs in spermatogenesis: insights from recent high-throughput transcriptome studies

Luk¹,

Chan²,

Rennert³

et al. 2014

Reproduction

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Spermatogenesis is a complex developmental process in which undifferentiated spermatogonia are differentiated into spermatocytes and spermatids through two rounds of meiotic division and finally giving rise to mature spermatozoa (sperm). These processes involve many testis-or male germ cell-specific gene products that undergo strict developmental regulations. As a result, identifying critical, regulatory genes controlling spermatogenesis provide the clues not only to the regulatory mechanism of spermatogenesis at the molecular level, but also to the identification of candidate genes for infertility or contraceptives development. Despite the biological importance in male germ cell development, the underlying mechanisms of stage-specific gene regulation and cellular transition during spermatogenesis remain largely elusive. Previous genomic studies on transcriptome profiling were largely limited to protein-coding genes. Importantly, protein-coding genes only account for a small percentage of transcriptome; the majority are noncoding transcripts that do not translate into proteins. Although small noncoding RNAs (ncRNAs) such as microRNAs, siRNAs, and Piwi-interacting RNAs are extensively investigated in male germ cell development, the role of long ncRNAs (lncRNAs), commonly defined as ncRNAs longer than 200 bp, is relatively unexplored. Herein, we summarize recent transcriptome studies on spermatogenesis and show examples that a subset of noncoding transcript population, known as lncRNAs, constitutes a novel regulatory target in spermatogenesis.

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Small RNAs in spermatogenesis

Cited by 115 publications

References 113 publications

MOV10L1 in piRNA processing and gene silencing of retrotransposons during spermatogenesis

MOV10L1 in piRNA processing and gene silencing of retrotransposons during spermatogenesis

Association of a TDRD1 variant with spermatogenic failure susceptibility in the Han Chinese

Long noncoding RNAs in spermatogenesis: insights from recent high-throughput transcriptome studies

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