2004
DOI: 10.1111/j.1365-2958.2004.04209.x
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Abstract: SummaryBarring genetic manipulation, the diet known as calorie restriction (CR) is currently the only way to slow down ageing in mammals. The fact that CR works on most species, even microorganisms, implies a conserved underlying mechanism. Recent findings in the yeast Saccharomyces cerevisiae indicate that CR extends lifespan because it is a mild biological stressor that activates Sir2, a key component of yeast longevity and the founding member of the sirtuin family of deacetylases. The sirtuin family appears… Show more

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Cited by 228 publications
(146 citation statements)
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“…CR probably acts as a mild stress and provokes the organism to mount a defence mechanism against it, ultimately leading to longevity. This could be a probable mechanism for life span extension by CR in accordance with the hormesis theory [10,11].…”
Section: Introductionsupporting
confidence: 63%
“…CR probably acts as a mild stress and provokes the organism to mount a defence mechanism against it, ultimately leading to longevity. This could be a probable mechanism for life span extension by CR in accordance with the hormesis theory [10,11].…”
Section: Introductionsupporting
confidence: 63%
“…This precludes conclusions regarding whether older adults are less adaptable to exercise training than young adults or if the volume and duration of the training were insufficient to reveal the full potential for adaptation. Furthermore, it remains to be determined whether long-term endurance exercise shares some of the biochemical effects of caloric restriction, which prolongs the lifespan of many species through the DNA-stabilizing actions of sirtuins (18), in particular the mitochondrial localized SIRT3 (19).…”
mentioning
confidence: 99%
“…A number of recent microarray studies have found that metabolic genes are disproportionately influenced by environmental stress, senescence, and inbreeding treatments (Girardot et al 2004;Landis et al 2004;Wang et al 2004;Englander 2005;Kristensen et al 2005). At a broad level, the role of metabolism in these processes may account for interactions between environmental stress and the magnitude of inbreeding depression (Crnokrak and Roff 1999;Keller and Waller 2002;Armbruster and Reed 2005), quantitative genetic correlations between stress resistance and extended life span Rose et al 1992;Force et al 1995;Zwaan et al 1995;Chippindale et al 1998;Norry and Loeschcke 2003), and similarities among the molecular effects of stress, inbreeding, and aging treatments observed in several species (Chen et al 2002;Brunet et al 2004;Lamming et al 2004;Colotti et al 2005;Kristensen et al 2005).…”
Section: Discussionmentioning
confidence: 99%