“…For example, gabapentin, which is clinically utilized for treating epilepsy and neuropathic pain, targets HVACC α 2 -δ subunits (Gee et al, 1996). Based on the presumption that the association of α 1 with β is obligatory for the formation of surface-targeted functional HVACCs as indicated by heterologous expression experiments (Buraei and Yang, 2010), disruption of the α 1 -β interaction has been long pursued as a strategy to develop HVACC inhibitors (Young et al, 1998; Findeisen et al, 2017; Chen, 2018; Khanna et al, 2019). To this end, over-expression of peptides derived from the α 1 -interaction domain (AID) which contains the amino acid sequence responsible for high-affinity α 1 -β association (Pragnell et al, 1994; Van Petegem et al, 2004; Chen et al, 2004; Opatowsky et al, 2003), has been utilized by several groups as putative genetically-encoded HVACC inhibitors (Findeisen et al, 2017; Yang et al, 2019).…”