Small Fiber Neuropathy and Wilson Disease

Gondim, Francisco de Assis Aquino; Filha, Joana Gurgel Holanda

doi:10.1167/iovs.15-17241

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2015

2024

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Cited by 2 publications

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“…los primeros resultados empiezan a registrar un buen correlato entre la densidad neuronal en el plexo subbasal de la córnea, los síntomas disautonómicos y las características del dolor en pacientes con fibromialgia 35 . Ya existen estudios en diabetes mellitus 30 , enfermedades neuropáticas genéticamente determinadas como el Charcot-Marie-Tooth36, la esclerosis lateral amiotrofica 37 , la enfermedad de Wilson 38 o la enfermedad de Parkinson 39 , por poner algunos ejemplos.…”

Section: Métodos Diagnósticosunclassified

Estudio y manejo de las neuropatías de fibra fina

Esteban¹,

Merino²,

Teijeira-Portas³

et al. 2024

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Section: Métodos Diagnósticosunclassified

Estudio y manejo de las neuropatías de fibra fina

Esteban¹,

Merino²,

Teijeira-Portas³

et al. 2024

KRANION

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Author Response: Small Fiber Neuropathy and Wilson Disease

Midena

2015

Invest. Ophthalmol. Vis. Sci.

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We appreciate the comments that Gondim and Gurgen Filha 1 have reported about our article, 2 which has demonstrated, for the first time, corneal nerve fiber involvement in Wilson disease documented by corneal confocal microscopy. They report the use of confocal microscopy, not corneal but reflectance skin confocal microscopy, to determine Meissner corpuscle changes in sensory neuropathy, a different field of investigation compared with our article. 3 Moreover, the original article was written by Herrmann et al. 4 It is not new that corneal confocal microscopy is able to demostrate small fiber peripheral neuropathy in diabetes, and we were the first research group to introduce in the literature the term ''corneal diabetic neuropathy,'' in 2006. 5 We have reviewed the article by Gondim et al. 6 about small fiber dysfunction in Wilson disease, but it has nothing to do with our investigation. Skin wrinkling test has never been compared with corneal confocal study of subbasal nerve plexus, and it may represent a topic for future studies. In our population, we did not find any difference in corneal involvement, even when separately evaluating central nervous system versus pure hepatic involvement. We congratulate Gondim et al. 6 for their prospective studies, and we hope they are able to include the evaluation of cornal subasal nerve plexus by corneal confocal microscopy in their prospective analysis.

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Small Fiber Neuropathy and Wilson Disease

Cited by 2 publications

References 5 publications

Estudio y manejo de las neuropatías de fibra fina

Estudio y manejo de las neuropatías de fibra fina

Author Response: Small Fiber Neuropathy and Wilson Disease

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