2018
DOI: 10.18632/aging.101452
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Abstract: Loss of functionality during aging of cells and organisms is caused and accompanied by altered cell-to-cell communication and signalling. One factor thereby is the chronic accumulation of senescent cells and the concomitant senescence-associated secretory phenotype (SASP) that contributes to microenvironment remodelling and a pro-inflammatory status. While protein based SASP factors have been well characterized, little is known about small extracellular vesicles (sEVs) and their miRNA cargo. Therefore, we anal… Show more

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Cited by 127 publications
(100 citation statements)
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References 86 publications
(92 reference statements)
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“…More recent descriptions of the SASP have been expanded to include the secretion of EVs (Robbins, 2017;Takasugi, 2018). Extracellular vesicles derived from senescent cells exhibit multiple changes in cargo compared to healthy cells including changes in protein (Takasugi et al, 2017), and miRNA abundance (Terlecki-Zaniewicz et al, 2018). To date, studies have focused on changes in EV cargo and functions in vitro.…”
Section: Discussionmentioning
confidence: 99%
“…More recent descriptions of the SASP have been expanded to include the secretion of EVs (Robbins, 2017;Takasugi, 2018). Extracellular vesicles derived from senescent cells exhibit multiple changes in cargo compared to healthy cells including changes in protein (Takasugi et al, 2017), and miRNA abundance (Terlecki-Zaniewicz et al, 2018). To date, studies have focused on changes in EV cargo and functions in vitro.…”
Section: Discussionmentioning
confidence: 99%
“…There are increasing lines of evidence suggesting that sEVs may constitute part of the SASP by mediating paracrine effects on the nearby microenvironment 63,64 . A recent study using a Crereporter system demonstrated a positive correlation between sEV uptake and senescence activation, and identified IFITM3 within sEVs partially responsible for transmitting paracrine senescence to normal cells 65 .…”
Section: Discussionmentioning
confidence: 99%
“…Remarkably, EVs secreted from senescent cells have unique characteristics and contribute to regulate the behavior of recipient cells similarly to soluble SASP factors . By analyzing EVs from senescent human dermal fibroblasts, Terlecki‐Zaniewicz and colleagues have identified a set of selectively retained or secreted miRNAs and have shown that senescent cell‐derived EVs with their miRNA cargo contribute to an antiapoptotic environment in tissues where senescent cells accumulate . Furthermore, ovarian cancer‐derived exosomes expressing miRNA‐433 have the potential to modulate the tumor microenvironment by inducing cellular senescence in neighboring cells .…”
Section: Evs As a Key Component Of Sasp Modulate Nk Cell Functionsmentioning
confidence: 99%
“…56,57 By analyzing EVs from senescent human dermal fibroblasts, Terlecki-Zaniewicz and colleagues have identified a set of selectively retained or secreted miRNAs and have shown that senescent cell-derived EVs with their miRNA cargo contribute to an antiapoptotic environment in tissues where senescent cells accumulate. 58 Furthermore, ovarian cancer-derived exosomes expressing miRNA-433 have the potential to modulate the tumor microenvironment by inducing cellular senescence in neighboring cells. 59 In addition to miRNA pattern, also protein profile significantly changes in senescent cell-derived exosomes, as described by a proteomic study demonstrating that EVs derived from drug-induced senescent breast cancer cells contain proteins involved in cell proliferation, ATP depletion, and apoptosis.…”
Section: Evs As a Key Component Of Sasp Modulate Nk Cell Functionsmentioning
confidence: 99%