Small doses of morphine can enhance NK cell cytotoxicity in pigs

Borman, A.; Ciepielewski, Z.; Wrona, Danuta; Stojek, W.; Glac, W.; Leszkowicz, Emilia; Tokarski, J

doi:10.1016/j.intimp.2008.11.006

Cited by 19 publications

(9 citation statements)

References 69 publications

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“…Similarly, in catheterized Pietrain crossbred pigs, morphine treatment induced a dose- and time-dependent increase in NK cell cytotoxicity in a naltrexone reversible manner. A 0.5 mg/kg (low dose) morphine treatment evoked a four-fold increase in porcine NK cell cytotoxicity compared to saline control, without eliciting changes in the number of circulating large granular lymphocytes or NK cells (Borman et al, 2009), indicating that enhancement of NK cell cytotoxicity occurs independently of NK cell recirculation.…”

Section: Morphine Modulation Of Innate Immune Functionmentioning

confidence: 99%

Opioid Drug Abuse and Modulation of Immune Function: Consequences in the Susceptibility to Opportunistic Infections

Roy

Ninković

Banerjee

et al. 2011

J Neuroimmune Pharmacol

261

228

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Infection rate among intravenous drug users (IDU) is higher than the general public, and is the major cause of morbidity and hospitalization in the IDU population. Epidemiologic studies provide data on increased prevalence of opportunistic bacterial infections such as TB and pneumonia, and viral infections such as HIV-1 and hepatitis in the IDU population. An important component in the intravenous drug abuse population and in patients receiving medically indicated chronic opioid treatment is opioid withdrawal. Data on bacterial virulence in the context of opioid withdrawal suggest that mice undergoing withdrawal had shortened survival and increased bacterial load in response to Salmonella infection. As the body of evidence in support of opioid dependency and its immunosuppressive effects is growing, it is imperative to understand the mechanisms by which opioids exert these effects and identify the populations at risk that would benefit the most from the interventions to counteract opioid immunosuppressive effects. Thus, it is important to refine the existing animal model to closely match human conditions and to cross-validate these findings through carefully controlled human studies. Better understanding of the mechanisms will facilitate the search for new therapeutic modalities to counteract adverse effects including increased infection rates. This review will summarize the effects of morphine on innate and adaptive immunity, identify the role of the mu opioid receptor in these functions and the signal transduction activated in the process. The role of opioid withdrawal in immunosuppression and the clinical relevance of these findings will also be discussed.

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Section: Morphine Modulation Of Innate Immune Functionmentioning

confidence: 99%

Opioid Drug Abuse and Modulation of Immune Function: Consequences in the Susceptibility to Opportunistic Infections

Roy

Ninković

Banerjee

et al. 2011

J Neuroimmune Pharmacol

261

228

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“…Prolonged use of opioids increases activity in the hypothalamic–pituitary–adrenal axis, thereby increasing the release of immunosuppressive glucocorticoids and decreasing T‐cell function and NK cell cytotoxicity. As pain/stress activates this axis, opioids used as analgesics might be protective (Hernandez et al, ; Mellon and Bayer, ; Borman et al, ; Zhang et al, ).…”

Section: Mechanisms Of Immune Effects Of Opioidsmentioning

confidence: 99%

“…The literature generally reports that morphine (Yeager et al, ; Franchi et al, ) and fentanyl (Martucci et al, ; Shavit et al, ; Franchi et al, ) decrease NK cell cytotoxicity, that buprenorphine does not affect NK cell cytotoxicity (Martucci et al, ; Franchi et al, ) and that tramadol enhances it (Sacerdote et al, ; Gaspani et al, ) (Table ). However, effects on NK cell cytotoxicity are likely to be dose‐dependent, as low‐dose morphine has been shown to stimulate cytotoxicity and high‐dose morphine to induce an initial increase in cytotoxicity followed by a suppression of cytotoxicity in pigs (Borman et al, ).…”

Section: Animal Studies: Anti‐tumour Immunity and Tumour Growthmentioning

confidence: 99%

Influence of opioids on immune function in patients with cancer pain: from bench to bedside

Boland

Pockley

2017

British J Pharmacology

141

130

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“…Recent studies show that transplantation into the paraventricular nucleus of hypothalamus of in vitro differentiated embryonic hypothalamic neurons producing increased quantities of β -endorphin results in significant increases in NK cell tumoricidal activity and NK-cell related resistance to N -methyl- N -nitrosourea induction of prostate cancers in rats [74]. In humans, β -endorphin has also been shown to induceincrease in NK cell cytotoxic activity [73]. …”

Section: Nk Cells Are Important Effectors Of Anticancer Immune Mecmentioning

confidence: 99%

“…When the blood-borne β -endorphin arrives to lymphoid tissues, it probably binds to opioid receptors expressed on the surface of NK cells [85, 86]. The bound β -endorphin stimulates NK cells to increase the expression of cell adhesion molecules, cytotoxic molecules such as granzyme B and perhaps perforin, TNF superfamily ligands [45, 49, 52, 71–73], and the secretion of cytokines such as IFN- γ into the cellular microenvironment [87]. These processes directly and indirectly promote NK cell tumoricidal activities and their ability to eliminate tumor cells and control tumor growth.…”

Section: Molecular Mechanisms Of Actionmentioning

confidence: 99%

Acupuncture May Stimulate Anticancer Immunity via Activation of Natural Killer Cells

Johnston¹,

Ortíz‐Sánchez

Vujanović

et al. 2011

Evidence-Based Complementary and Alternative Medicine

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This article presents the hypothesis that acupuncture enhances anticancer immune functions by stimulating natural killer (NK) cells. It provides background information on acupuncture, summarizes the current scientific understanding of the mechanisms through which NK cells act to eliminate cancer cells, and reviews evidence that acupuncture is associated with increases in NK cell quantity and function in both animals and humans. The key contribution of this article involves the use of cellular immunology and molecular biological theory to interpret and synthesize evidence from disparate animal and human studies in formulating the ‘acupuncture immuno-enhancement hypothesis': clinicians may use acupuncture to promote the induction and secretion of NK-cell activating cytokines that engage specific NK cell receptors that endogenously enhance anticancer immune function.

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Small doses of morphine can enhance NK cell cytotoxicity in pigs

Cited by 19 publications

References 69 publications

Opioid Drug Abuse and Modulation of Immune Function: Consequences in the Susceptibility to Opportunistic Infections

Opioid Drug Abuse and Modulation of Immune Function: Consequences in the Susceptibility to Opportunistic Infections

Influence of opioids on immune function in patients with cancer pain: from bench to bedside

Acupuncture May Stimulate Anticancer Immunity via Activation of Natural Killer Cells

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