Small cell carcinoma of the lung with Leser-Trelat sign

Hattori, A.

doi:10.1001/archderm.118.12.1017

Cited by 10 publications

(8 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, lung cancer was detected 6 months after occurrence of LT5. Though it is common that LT5 and malignancy appear simultaneously, this sign has also been reported to precede the development of malignant tumor (7,19). Although the LT5 preceded the lung cancer, we finally diagnosed LT5 associated with 55, because a detailed examination of the patient had not revealed any abnormal pulmonary findings when LT5 was diagnosed, and the seborrheic keratoses did not deteriorate in number or size when the lung cancer was found.…”

Section: Report Of a Casementioning

confidence: 77%

Leser‐Trélat Sign Associated with Sézary Syndrome

Ikari

Ohkura

Morita

et al. 1995

The Journal of Dermatology

View full text Add to dashboard Cite

A 74-year-old Japanese male had developed generalized erythroderma and rapid growth of multiple verrucous lesions over the entire surface of his face, trunk, and extremities three months before he was seen. Histologically seborrheic keratoses were revealed. Laboratory examinations showed peripheral leukocytosis with atypical lymphocytes and high levels of IgE and IgG. On the basis of these clinical and histopathologic findings, we diagnosed the patient as having Leser-Trélat sign associated with Sézary syndrome. The erythroderma subsided after administration of oral predonisone, and no new formations of seborrheic keratosis were observed. However, because of subsequent aggravation of the generalized erythroderma, we administered chemotherapy. Six months after the initial examination, lung cancer was found, and the patient subsequently died of respiratory and renal failure.

show abstract

Section: Report Of a Casementioning

confidence: 77%

Leser‐Trélat Sign Associated with Sézary Syndrome

Ikari

Ohkura

Morita

et al. 1995

The Journal of Dermatology

View full text Add to dashboard Cite

show abstract

“…5 In the literature, rare cases of LT sign associated with lung cancer were reported. 4,6,7 Heaphy et al 4 were the first to report the sign of LT in association of adenocarcinoma of the lung in 2000. To prove the association with malignant disease, Swartz et al 2 did a retrospective review of 1752 patients with seborrheic keratoses and they found that within 1 year, 62 patients was diagnosed with visceral malignancy.…”

Section: Discussionmentioning

confidence: 99%

“…This association was due to the high level of epidermal growth factor receptors (EGFR) protein expressed by the tumor postulated many writers. High levels of EGFR might play a role for the development of seborrheic keratoses 1,2,4,6 . In a review of literature included 121 cases with a mean patient age of 61.8 years, the authors found that this syndrome was observed before (68.3%), after (22.1%), and at the time of (9.6%) malignancy diagnosis 8 .…”

Section: Discussionmentioning

confidence: 99%

Leser‐Trélat syndrome secondary to non‐small‐cell lung carcinoma

Khemakhem

Kallel

Jarraya

et al. 2022

Clinical Case Reports

View full text Add to dashboard Cite

show abstract

“…Lung carcinomas are the fourth most common cause of the Leser–Trélat sign and include squamous cell carcinoma, 3 small cell carcinoma, 18 and large cell carcinoma 1 . One patient had both a squamous cell carcinoma and an adenocarcinoma of the lung on histologic examination 19 .…”

Section: Discussionmentioning

confidence: 99%

Florid eruption of seborrheic keratoses associated with elevated insulin‐like growth factor, hypoglycemia, and solitary fibrous tumor of the pleura

et al. 2004

View full text Add to dashboard Cite

A 66-year-old man with a past medical history of hypertension and arthritis was hospitalized and treated for bacterial pneumonia. Chest X-ray revealed a left-sided chest mass. Computed tomography (CT) scan of the chest demonstrated a large heterogeneously enhancing mass occupying most of the left lower lobe and extending to the inferior aspect of the hilum. It measured 16.6 × 12 cm and caused a mild shift of the mediastinum to the right. The patient declined further work-up or surgical resection of the mass. Dermatologic examination was unremarkable at that time.Over the next 5 months, numerous skin lesions erupted on the patient's trunk. He then experienced several syncopal episodes, at which time he was found to be profoundly hypoglycemic. It was suspected that the chest tumor was producing high serum levels of insulin-like growth factor (IGF) resulting in hypoglycemia and syncope. Serum laboratory investigations were significant for glucose of 20 mg / dL (normal, 60 -120 mg / dL), IGF-1 of 39 ng / mL (normal, 152 -494 ng / mL), IGF-2 of 927 ng / mL (normal, 210 -750 ng / mL), and insulin of < 5.0 microunits (MCU)/ mL (normal, 0 -30 MCU/mL). Surgical extirpation of the chest tumor was recommended.The dermatology service was consulted to evaluate whether the numerous skin lesions in the area of planned surgery would pose an increased risk of infection. Cutaneous examination revealed a dense aggregation of pigmented hyperkeratotic plaques with a "stuck-on" appearance, predominantly localized on the trunk. Many were unusually large or darkly pigmented. A particularly dense distribution was apparent on the left side of the chest (Fig. 1a).Numerous large acrochordons were evident on the lower eyelids and in the axillary vaults.Acanthosis nigricans was not present. A biopsy specimen from a hyperkeratotic lesion on the left upper back revealed an acanthotic, hyperpigmented epidermis with a lamellar horn, anastomosing rete, and pseudohorn cysts (Fig. 1b).Left thoracotomy and left lower lobectomy were performed, and surgeons extirpated an 18 × 17 × 10 cm cystic, multilobular, hard tumor ( Fig. 2a) adhering to the left diaphragm, left lower lobe, and left parietal pleura. Pathologic examination revealed a highly cellular spindle cell tumor (Fig. 2b). The nuclei were relatively monotonous with few mitoses. No areas of necrosis were identified. These pathologic findings were diagnostic for solitary fibrous tumor of the pleura.After surgery, the patient experienced no further syncopal episodes. The truncal seborrheic keratoses decreased substantially in number, size, and density over the following 6 months.Post-operative laboratory data revealed normalization of the blood glucose, insulin, IGF-1 (191 ng/mL; normal, 71-290 ng / mL), and IGF-2 (515 ng / mL; normal, 358 -854 ng / mL). DiscussionThe Leser-Trélat sign is a paraneoplastic phenomenon characterized by the sudden appearance and rapid increase in the size and number of seborrheic keratoses (SK). This occurs in association with internal malignancy, most commonly gastr...

show abstract

Small cell carcinoma of the lung with Leser-Trelat sign

Cited by 10 publications

References 0 publications

Leser‐Trélat Sign Associated with Sézary Syndrome

Leser‐Trélat Sign Associated with Sézary Syndrome

Leser‐Trélat syndrome secondary to non‐small‐cell lung carcinoma

Florid eruption of seborrheic keratoses associated with elevated insulin‐like growth factor, hypoglycemia, and solitary fibrous tumor of the pleura

Contact Info

Product

Resources

About