Small bowel motility following major intra-abdominal surgery: The effects of opiates and rectal cisapride

Benson, Martin; Roberts, Julian; Wingate, David; Rogers, John E.; Deeks, Jonathan J; Castillo, Fortunato D.; Williams, Norman S.

doi:10.1016/0016-5085(94)90751-x

Cited by 65 publications

(29 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…7 In addition, some experimental studies reported that only abdominal surgery induced intestinal dysmotility. 5 In the present study, colonic motility changes-initial increase and subsequent gradual decrease in the NC and DC after the surgery-were observed in the control group. Huge et al showed that laparotomy and manipulation of the cecum induced postoperative dysmotility of the colon, namely, postoperative ileus.…”

Section: Discussionsupporting

confidence: 48%

“…The pathophysiology of such dysmotility, also known as postoperative ileus, has been investigated by several reports. [5][6][7][8] Although functional changes associated with experimentally induced ischemic injuries to the intestinal mucosa have been widely studied, only a few experimental studies have investigated ischemic injury-induced changes in intestinal motility. [2][3][4][9][10][11] Moreover, these studies have been performed using in vitro models.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The effects of intestinal ischemia on colonic motility in conscious rats

et al. 2008

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 48%

Section: Introductionmentioning

confidence: 99%

The effects of intestinal ischemia on colonic motility in conscious rats

et al. 2008

View full text Add to dashboard Cite

show abstract

“…Although some studies have demonstrated that appropriate bowel preparation and use of prokinetic agents could improve the SBTT and the cecal completion rate of CE [17,24,25], the usefulness of such agents, in particular, for the completion rate of CE, is controversial. Although a positive effect of cisapride and Dai-kenchu-to on gastrointestinal dysmotility after abdominal surgery has been reported [26,27], it is unknown whether these prokinetic agents can really improve the transit time and the cecal completion rate of CE. This needs to be investigated by a prospective study in the future.…”

Section: Discussionmentioning

confidence: 99%

Abdominal Surgery Affects Small Bowel Transit Time and Completeness of Capsule Endoscopy

et al. 2008

View full text Add to dashboard Cite

The aim of the study was to evaluate bowel dysmotility in patients with a history of abdominal surgery by measuring both gastric transit time and small bowel transit time during capsule endoscopy and assessing the completeness of the examination. The study included 26 patients who had undergone abdominal surgery (postoperative group) and 52 patients who had not (control group). The capsule reached the cecum in 50.0% of the postoperative group and 80.8% of the control group (P=0.005). While there was no significant difference in gastric transit time between the two groups (P=0.882), small bowel transit time was significantly longer in the postoperative group (338.3+/-119.2 min) than in the control group (266.4+/-110.8 min, P=0.010). This is the first study to report that the small bowel transit time during capsule endoscopy is prolonged in patients who had a history of abdominal surgery, resulting in a lower frequency of complete examination.

show abstract

“…An alternative approach has been the use of prokinetic agents such as metoclopramide, erythromycin, and cisapride to stimulate postoperative gastrointestinal motility. Trials using these agents, however, have shown them to be ineffective [7][8][9].…”

Section: Introductionmentioning

confidence: 99%