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Cited by 10 publications
(11 citation statements)
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References 5 publications
(6 reference statements)
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“…Secretory leukocyte protease inhibitor (SLPI) promotes cell proliferation, invasion, metastasis, and drug resistance. 51,52 In patients with HR HPV positive low or high grade squamous intraepithelial lesions, SLPI concentrations in the cervical mucus were increased compared to controls. 53 These results, combined with our finding that SLPI was significantly upregulated in cervical cancers (Figures 3 and 4), merit further investigation of the role of SLPI in cervical cancers.…”
Section: Discussionmentioning
confidence: 99%
“…Secretory leukocyte protease inhibitor (SLPI) promotes cell proliferation, invasion, metastasis, and drug resistance. 51,52 In patients with HR HPV positive low or high grade squamous intraepithelial lesions, SLPI concentrations in the cervical mucus were increased compared to controls. 53 These results, combined with our finding that SLPI was significantly upregulated in cervical cancers (Figures 3 and 4), merit further investigation of the role of SLPI in cervical cancers.…”
Section: Discussionmentioning
confidence: 99%
“…We found that aldo-keto reductase family 1 member B10 ( AKR1B10 ), NAD(P)H quinone dehydrogenase 1 ( NQO1 ), and aldo-keto reductase family 1 member C3 ( AKR1C3 ) are highly expressed in HLRCC-associated kidney cancer relative to the other cancer types, all of which have been reported to be highly expressed in HLRCC-associated kidney cancer in association with a dysregulated Kelch-like ECH-associated protein 1 (KEAP1)-nuclear factor erythroid 2-related factor 2 (NRF2) axis ( Figure 3 A) ( Ooi et al., 2011 ). In addition, we found that carboxypeptidase D ( CPD ), growth Differentiation Factor 15 ( GDF15 ), S100 calcium binding protein A6 ( S100A6 ), secretory leukocyte peptidase inhibitor ( SLP1 ), paired box 2 ( PAX2 ), KCNQ1 opposite strand/antisense transcript 1 ( KCNQ1OT1 ), metastasis associated in lung adenocarcinoma transcript-1 ( MALAT1 ), and insulin like growth factor 2 mRNA binding protein 2 ( IGF2BP2 ) are highly expressed in HLRCC-associated kidney cancer relative to the other cancer types, all of which have been reported to be expressed in highly aggressive cancers with poor prognosis ( Chen et al., 2015 ; Feng et al., 2020 ; Gao et al., 2021 ; Han et al., 2020 ; Miyazaki et al., 2019 ; Munn and Garkavtsev, 2018 ; Shi et al., 2019 ; Wang et al., 2020 ; Ye et al., 2021 ; Yi et al., 2021 ; Zhang et al., 2021a ). Using Gene Set Enrichment Analysis (GSEA), we compared three types of hereditary kidney cancers and found that gene sets related to cell migration and metastasis were enriched in HLRCC-associated kidney cancer, consistent with the fact that this highly aggressive kidney cancer subtype has a propensity to metastasize from a small primary lesion ( Figure 3 B).…”
Section: Resultsmentioning
confidence: 99%
“…SLPI, a known immunomodulator that functions to downregulate the immune system [ 30 ], and KRT16, a stress keratin with a role in innate immunity [ 31 ], were also highly upregulated in response to 16E6E7 expression in HFKs. HFK2 E6E7 exhibited a stark increase of 10–20-fold for both of these genes; HFK1 and HFK3 E6E7 returned less pronounced, yet still statistically significant increases of 2–3-fold ( Figure 5 A, colored bars).…”
Section: Resultsmentioning
confidence: 99%