Slow Sodium Acetate Infusion in the Correction of Metabolic Acidosis in Premature Infants

Water, Sodium and Acid‐Base Balance in Premature Infants: Therapeutical Aspects

“…The slow and continuous infusion of sodium acetate was efficient and practical in our patient material as normal acid-base balance was maintained. This observation accords with our previous experience (2). Though high intake has been associated with hypotension, obviously due to vasodilatation (22), no such effect was seen in this study.…”

A novel isotonic balanced electrolyte solution with 1% glucose for intraoperative fluid therapy in neonates: results of a prospective multicentre observational postauthorisation safety study (PASS)

“…Acetate is an alternative bicarbonate precursor to lactate which is metabolised significantly faster, more independently of hepatic function, causes a smaller increase in oxygen consumption and has no interference with the diagnostic use of lactate as a marker of low tissue perfusion (6). Acetate has previously been used for intraoperative fluid therapy (8-10) and correction of acidosis even in neonates and preterms (11), and therefore, we found nearly stable acid-base parameters and lactate concentrations also in this age group. In contrast to our study in older children (4), there was a slight tendency toward hyperchloraemic acidosis in neonates.…”

A novel isotonic-balanced electrolyte solution with 1% glucose for intraoperative fluid therapy in children: results of a prospective multicentre observational post-authorization safety study (PASS)

“…Acetate is an alternative to lactate because it is metabolized significantly faster, more independently of hepatic function, with a smaller increase in oxygen consumption and no interference with the diagnostic use of lactate as a marker of low tissue perfusion (16). Acetate was used for correction of acidosis even in neonates and preterms (18), and therefore we found stable acid–base parameters and lactate concentrations in all patients studied, regardless of age.…”