Slow Release Cisplatin Combined With Radiation for the Treatment of Canine Nasal Tumors

Lana, Susan E.; Dernell, William S.; LaRue, Susan M.; Lafferty, Mary J.; Douple, Evan B.; Brekke, John H.; Withrow, Stephen J.

doi:10.1111/j.1740-8261.1997.tb00875.x

Cited by 67 publications

(52 citation statements)

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“…1,2 However, in animals (like in humans), antineoplastic agents cause a number of side effects concerning the bone marrow, the gastroenteric apparatus, and the skin. 3 The toxicity of conventional systemic cancer chemotherapy has severely limited its safety and effectiveness.…”

Section: Introductionmentioning

confidence: 99%

Spray-dried poly(D,L-lactide) microspheres containing carboplatin for veterinary use: In vitro and in vivo studies

et al. 2005

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The aim of this study was the development of a veterinary dosage form constituted by injectable biodegradable microspheres designed for the subcutaneous release of carboplatin, a chemotherapeutic drug. Poly(D,L-lactide) (PDLLA) microspheres were prepared by an emulsification/spray-drying method, using the drug-to-polymer weight ratios 1:9 and 1:5; blank microspheres (1% w/v) were prepared as a comparison. Microparticles were characterized in terms of morphology, encapsulation efficiency, and in vitro drug release behavior. In vivo tests were conducted on rats by subcutaneous injection of microsphere aqueous suspensions. Levels of carboplatin were evaluated both in the skin and in serum. The microparticles obtained had a spherical shape; particle size ranged from 5 to 7 mm, dependent on drug loading. Microspheres were able to control the in vitro release of the drug: approximately 90% to 100% of the carboplatin was released over 30 days. In vivo results showed that the microspheres were able to release high drug amounts locally, and sustained serum levels of drug were also achieved. Based on these results, carboplatin-loaded PDLLA microspheres may be useful for local delivery of the antineoplastic drug to the tumor, avoiding tumor recurrence in small animals, and may decrease the formation of distant metastases.

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Section: Introductionmentioning

confidence: 99%

Spray-dried poly(D,L-lactide) microspheres containing carboplatin for veterinary use: In vitro and in vivo studies

et al. 2005

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“…A combination of surgery, radiation, and/or chemotherapy is a standard treatment modality for nasal tumors in dogs [5,7,10,14,16,19]. The choice of treatment greatly depends on the location and size of the tumors obtained using radiography.…”

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confidence: 99%

Prognosis of Canine Patients with Nasal Tumors According to Modified Clinical Stages Based on Computed Tomography: A Retrospective Study

et al. 2008

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ABSTRACT. To evaluate the efficacy of clinical staging based on computed tomography (CT) imaging over the World Health Organization (WHO) staging system based on radiography for nasal tumors in dogs, a retrospective study was conducted. This study used 112 dogs that had nasal tumors; they had undergone radiography and CT and had been histologically confirmed as having nasal tumors. Among 112 dogs, 85 (75.9%) were diagnosed as adenocarcinoma. Then they were analyzed for survival time according to each staging system. More than 70% of the patients with adenocarcinoma were classified as having WHO stage III. The patients classified under WHO stage II tended to survive longer than those classified under WHO stage III. Dogs classified under WHO stage III were further grouped into CT stages III and IV, and CT stage III patients had a significantly longer survival time than CT stage IV patients. In addition, patients treated with a combination of surgery and radiation had a significantly longer survival time than the patients who did not receive any treatment in CT stage III. On the other hand, different treatment modalities did not show a significant difference in the survival time of CT stage IV dogs. The results suggest that WHO stage III dogs may have various levels of tumor progression, indicating that the CT staging system may be more accurate than the WHO staging system.

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“…Therapy is based upon local disease control, and it involves surgery [14], chemotherapy [15], radiation therapy [3,16] and immunotherapy, or combination [9,17]. Although surgical approach to those tumors is not suggested by some authors, it still retains its place in selected cases [14].…”

Section: Introductionmentioning

confidence: 99%

Magnetic Resonance Imaging and Histological Findings of Paranasal Sinus Tumors and Surgical Outcomes in Dogs and Cats

Can¹,

Vural²

2016

J Veterinar Sci Technol

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Objective of this study was to report Magnetic resonance imaging (MRI) features of histologically confirmed paranasal sinus tumors and surgical outcomes. Totally 17 dogs and 3 cats were included in the study. Medical records of dogs and cats which were presented between January 2008 and November 2015 due to paranasal sinus tumors were reviewed. Dogs and cats were included if they have full clinical findings, diagnosed by MRI, confirmed histologically, and treated just surgically. Collected data for sex, breed, age, tumor stage, localisation, surgical outcomes, histological diagnosis, survival time and cause of death were included. Soft tissue mass within the nasal cavity replacing the nasal conchae and/or ethmoturbinates and mass invading to the frontal sinuses were determined in 80% (n=16) of the cases in MRI. Nasal and/or frontal bones were destructed in 65% (n=13) of the cases. In 7 dogs bone flap was created to expose and remove the tumor, and the flap was replaced wired after operation. In 10 dogs and 3 cats frontal and/or nasal bone was involved by the tumor, and closure of the defects was carried out with PMMA and wire. In this case series 50% of the tumors were sarcomas, and it was followed by adenocarcinoma (20%) and neuroesthesioblastoma (15%) in decreased rates. Dedicated MRI examination is crucial for diagnosis of paranasal sinus tumors, and surgical intervention as sole treatments looks acceptable for providing better quality of life for certain time.

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Slow Release Cisplatin Combined With Radiation for the Treatment of Canine Nasal Tumors

Cited by 67 publications

References 10 publications

Spray-dried poly(D,L-lactide) microspheres containing carboplatin for veterinary use: In vitro and in vivo studies

Spray-dried poly(D,L-lactide) microspheres containing carboplatin for veterinary use: In vitro and in vivo studies

Prognosis of Canine Patients with Nasal Tumors According to Modified Clinical Stages Based on Computed Tomography: A Retrospective Study

Magnetic Resonance Imaging and Histological Findings of Paranasal Sinus Tumors and Surgical Outcomes in Dogs and Cats

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