Sleep spindle dynamics during NREM and REM sleep following distinct general anaesthesia in control rats and in a rat model of Parkinson’s disease cholinopathy

Lazic, Katarina; Ciric, Jelena; Saponjic, Jasna

doi:10.1111/jsr.12758

Cited by 6 publications

(4 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Than we concatenated all visually detected and extracted SS or HVS during NREM or REM of each group of rats for the analysis of SS or HVS dynamic (mean density; mean intrinsic frequency; mean duration per 1 h of NREM and REM sleep)” (Lazic et al, 2018).…”

Section: Methodsmentioning

confidence: 99%

Alterations of Sleep and Sleep Oscillations in the Hemiparkinsonian Rat

et al. 2019

Self Cite

View full text Add to dashboard Cite

Our previous studies in the rat model of Parkinson’s disease (PD) cholinopathy demonstrated the sleep-related alterations in electroencephalographic (EEG) oscillations at the cortical and hippocampal levels, cortical drives, and sleep spindles (SSs) as the earliest functional biomarkers preceding hypokinesia. Our aim in this study was to follow the impact of a unilateral substantia nigra pars compacta (SNpc) lesion in rat on the cortical and hippocampal sleep architectures and their EEG microstructures, as well as the cortico-hippocampal synchronizations of EEG oscillations, and the SS and high voltage sleep spindle (HVS) dynamics during NREM and REM sleep. We performed unilateral SNpc lesions using two different concentrations/volumes of 6-hydroxydopamine (6-OHDA; 12 μg/1 μl or 12 μg/2 μl). Whereas the unilateral dopaminergic neuronal loss >50% throughout the overall SNpc rostro-caudal dimension prolonged the Wake state, with no change in the NREM or REM duration, there was a long-lasting theta amplitude augmentation across all sleep states in the motor cortex (MCx), but also in the CA1 hippocampus (Hipp) during both Wake and REM sleep. We demonstrate that SS are the hallmarks of NREM sleep, but that they also occur during REM sleep in the MCx and Hipp of the control rats. Whereas SS are always longer in REM vs. NREM sleep in both structures, they are consistently slower in the Hipp. The dopaminergic neuronal loss increased the density of SS in both structures and shortened them in the MCx during NREM sleep, without changing the intrinsic frequency. Conversely, HVS are the hallmarks of REM sleep in the control rats, slower in the Hipp vs. MCx, and the dopaminergic neuronal loss increased their density in the MCx, but shortened them more consistently in the Hipp during REM sleep. In addition, there was an altered synchronization of the EEG oscillations between the MCx and Hipp in different sleep states, particularly the theta and sigma coherences during REM sleep. We provide novel evidence for the importance of the SNpc dopaminergic innervation in sleep regulation, theta rhythm generation, and SS/HVS dynamics control. We suggest the importance of the underlying REM sleep regulatory substrate to HVS generation and duration and to the cortico-hippocampal synchronizations of EEG oscillations in hemiparkinsonian rats.

show abstract

Section: Methodsmentioning

confidence: 99%

Alterations of Sleep and Sleep Oscillations in the Hemiparkinsonian Rat

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

“…Moreover, significant sleep spindle (SS) alterations and high voltage spindles (HVS; 5-13 Hz) were observed: the unilateral SNpc lesion increased the density of the SS during NREM sleep in both the motor cortex and the hippocampus. While debate surrounds the function of HVS (being analogous to the human mu rhythms) [ 232 ], evidence suggests that HVS and SS dynamics are regulated by thalamo-cortical circuits and that abnormal dynamics reflect the dysfunction of these circuits [ 233 ]. Further, EEG oscillation synchronization was significantly impacted in the 6-OHDA model.…”

Section: Circadian and Sleep Phenotypes Of Murine Models Of Pdmentioning

confidence: 99%

Sleep and circadian rhythms in Parkinson’s disease and preclinical models

Hunt

Coulson

Rajnarayanan

et al. 2022

Mol Neurodegeneration

View full text Add to dashboard Cite

The use of animals as models of human physiology is, and has been for many years, an indispensable tool for understanding the mechanisms of human disease. In Parkinson’s disease, various mouse models form the cornerstone of these investigations. Early models were developed to reflect the traditional histological features and motor symptoms of Parkinson’s disease. However, it is important that models accurately encompass important facets of the disease to allow for comprehensive mechanistic understanding and translational significance. Circadian rhythm and sleep issues are tightly correlated to Parkinson’s disease, and often arise prior to the presentation of typical motor deficits. It is essential that models used to understand Parkinson’s disease reflect these dysfunctions in circadian rhythms and sleep, both to facilitate investigations into mechanistic interplay between sleep and disease, and to assist in the development of circadian rhythm-facing therapeutic treatments. This review describes the extent to which various genetically- and neurotoxically-induced murine models of Parkinson’s reflect the sleep and circadian abnormalities of Parkinson’s disease observed in the clinic.

show abstract

“…5e exhibit more spurious oscillations (t 3 -t ON ), which are suspected to be sleeping spindles. 17 Although these oscillations exhibit highest energy within 3-5 Hz (t 3 -t ON in Fig. 5f), the energies in 5-13 Hz are also relatively higher in the period encircled by the dashed-line, as compared with the non-spindling LFPs in Fig.…”

Section: Performance Comparisonmentioning

confidence: 88%

“…As PD mainly results from the depletion of dopaminergic neurons, the local field potentials (LFPs) recorded from the basal-ganglia-thalamocortical network are useful for indicating the state of a parkinsonian brain. 7,15,21,23 The elevated beta-band synchrony (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) in the LFPs is associated with bradykinesia and rigidity. 1,19,24,26 Several studies demonstrate that closed-loop DBS (cDBS) is superior to open-loop DBS in ameliorating the beta-band synchrony.…”

Section: Introductionmentioning

confidence: 99%