Sleep Hypoxemia in Young Adults With Cystic Fibrosis

Relationship between airway obstruction, desaturation during exercise and nocturnal hypoxaemia in cystic fibrosis patients

“…Desaturation during exercise and sleep was only found in patients with a FEY 1 less than 65% of predicted. With respect to nocturnal desaturation these findings are in agreement with those of SToKEs et al [6] in a smaller number of patients (fig. 1).…”

“…We confirmed this with respect to nocturnal hypoxaemia. Analysis of the data published by SroKEs et al [6] in 8 patients gives the same correlation coefficient (r=0.84) as we found for the relation between resting So 1 in sitting position and nocturnal hypoxaemia.…”

Hypoventilation in Cystic Fibrosis

“…34 For example, Tepper et al evaluated gas exchange and breathing in six adolescents with moderate to severe CF. 35 As expected, based on previous reports, 33,36,37 there were significant gas exchange abnormalities with hypoxia and hypercarbia. 35 These findings were even more pronounced in rapid eye movement (REM) sleep, and associated with a 22% decrease in tidal volume during non-REM (NREM) sleep (p < 0.02), and 26% decrease in tidal volume during REM sleep (p < 0.05), without significant change in respiratory rate (p < 0.1).…”

Sleep architecture in children and adolescents with cystic fibrosis and the association with severity of lung disease

“…These conditions may emerge as the cause of sleep disruption as the severity of disease progresses. In fact, cough has been shown to result in sleep disruption in CF patients, and prolonged cough may delay progression to REM sleep [17]. The presence of nocturnal cough may result in a decrease in REM sleep in CF children as observed in the current study.…”