Sleep Disorders in Children With Cancer

Kaleyias, Joseph; Manley, Peter; Kothare, Sanjeev V.

doi:10.1016/j.spen.2012.02.013

Cited by 63 publications

(60 citation statements)

References 60 publications

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“…The depression resulted from the disease and its treatment, sleep disorders, pain and cognitive changes are some abnormalities which affect these patients (Kaleyias et al, 2012). Sleeping is one of the most important cycles during day and night and it also is a sophisticated biological pattern (Moller et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Sleep Quality and Associated Risk Factors in Leukemia Patients Undergoing Chemotherapy in Iran

Bagheri-Nesami

Goudarzian²,

Babaei³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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This study aimed to determine sleep disorders and associated risk factors in leukemia patients undergoing chemotherapy in Imam Khomeini Hospital of Sari, Iran. This cross-sectional study was conducted in 2015 with 100 patients selected. Inclusion criteria included complete mental and psychological health and being over 18 years old, and exclusion criteria included suffering other cancers, other chronic diseases, concurrent radiotherapy, and chemotherapy. The Pittsburgh Sleep Quality standard questionnaire was used to collect data. The questionnaire consisted of mental sleep quality, sleep latency, sleep duration, sleep quality, sleep disturbances, use of sleeping drugs, and impaired daily functioning. Data were analyzed by software SPSS 18 and by using descriptive and inferential tests (Pearson, Spearman, T-test and chi-square). Totals of 47 men (47%) and 53 women (53%) with a mean age of 44.1±1.7, participated in the study. The mean overall score of sleep quality was 9.3±3.9, which represents the average sleep quality in most participants. T-test shows that males have better sleep quality than females (t=2.1; 95%CI:0.004-0.25; P<0.01). Also the sleep quality increased with age (r=0.22, P=0.03). Results show that the amount of sleep quality was only moderate in most patients, so it is necessary to take coping strategies to improve their quality of sleep.

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Section: Introductionmentioning

confidence: 99%

Sleep Quality and Associated Risk Factors in Leukemia Patients Undergoing Chemotherapy in Iran

Bagheri-Nesami

Goudarzian²,

Babaei³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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“…A review by Rosen et al [2] found neurologic, neurobehavioral, and neuroendocrine complications to be common effects of cancer treatment in both the initial and long-term survival phases. Accordingly, endocrinopathies, sensory and motor deficits, pain, cognitive decline, heart failure, stroke, and epilepsy are among the commonly reported late effects of treatment in brain tumor survivors [1,2,7]. In addition, child survivors have rated the long-term treatment effects of fatigue and sleepiness as their most distressing symptom, and symptoms may go unrecognized until years after diagnosis [8].…”

Section: Introductionmentioning

confidence: 99%

“…While 50 to 60 % of all pediatric oncology patients experience fatigue and EDS, symptom prevalence increases to 80 % in children with brain tumors involving the hypothalamus, thalamus, and brainstem [7]. These symptoms result from the significant degree of tissue injury incurred from both the brain tumor and its treatment (e.g., surgery and CRT), which often lead to disruption of the circadian, homeostatic, physiological, and behavioral processes that initiate and regulate appropriate sleep patterns [2,4].…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, tumor-related damage to the hypothalamus has been associated with endocrine deficiencies and obesity, which in turn can result in obstructive sleep apnea that may contribute to EDS [9]. Finally, the psychological stress experienced by a child with cancer and his or her family may further serve to exacerbate sleep disturbances [7,10]. Because sleep is critical for neural recovery and tissue renewal, sleep problems in children with brain tumors are particularly salient as they have been shown to be related to tumor growth in mouse models [5,8,11] and may impair neurocognitive healing.…”

Section: Introductionmentioning

confidence: 99%

“…Although the prevalence of sleep disturbances among child and adolescent survivors is unknown, several studies suggest that insomnia, EDS, somnolence syndrome, sleep apnea, and narcolepsy are commonly diagnosed following surgery, chemotherapy, and CRT [1,6,7]. In a retrospective review of 14 pediatric brain tumor survivors referred to a sleep clinic for evaluation of sleep disruption, Rosen [13] found that seven children exhibited EDS, five had been diagnosed with narcolepsy, four had sleep-related breathing disorders, and one had seizures during sleep.…”

Section: Introductionmentioning

confidence: 99%

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Sleep complaints in survivors of pediatric brain tumors

Brimeyer

Adams

Zhu

et al. 2015

Support Care Cancer

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While survivors reported achieving recommended amounts of sleep each night, 20 to 30% reported EDS. Poor concordance among parent and adolescent report highlights the importance of obtaining self-report when assessing sleep concerns. Obesity is a modifiable factor in reducing symptoms of EDS in this population. Finally, the lack of association between EDS and brain tumor location, BMI, or treatment received was unexpected and warrants further investigation.

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High occurrence of sleep problems in survivors of a childhood brain tumor with neurocognitive complaints: The association with psychosocial and behavioral executive functioning

Kooten

Maurice‐Stam

Schouten

et al. 2019

Pediatric Blood & Cancer

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Background: Survivors of childhood brain tumors are prone to sleep and neurocognitive problems.Effective interventions to improve neurocognitive functioning are largely lacking. In general, sleep problems are negatively related to neurocognitive functioning, but this relationship is unclear in survivors of childhood brain tumors. Therefore, the occurrence of sleep problems, potential risk factors, and the relation between sleep and executive functioning were evaluated. Procedure: Baseline data of a randomized controlled trial on the effectiveness of neurofeedback were used. Childhood brain tumor survivors 8-18 years of age with parent-reported neurocognitive complaints ≥2 years after treatment were eligible. Parents completed the Sleep Disturbance Scale for Children. Executive functioning was assessed by parents and teachers (Behavior Rating Inventory of Executive Functioning). Multiple linear regression analyses were used to examine sociodemographic and medical characteristics and emotional difficulties and hyperactivity/inattention (Strength and Difficulties Questionnaire) as potential risk factors for sleep problems, and to assess the association between sleep and executive functioning. Results: Forty-eight percent of survivors (n = 82, 7.0 ± 3.6 years post diagnosis, age 13.8 ± 3.2 years) had sleep problems and scored significantly worse than the norm on the subscales Initiating and Maintaining Sleep, Excessive Somnolence, and the total scale (effect sizes 0.58-0.92). Emotional problems and/or hyperactivity/inattention were independent potential risk factors. Sleep problems were associated with worse parent-reported executive functioning. Conclusions: Sleep problems occur among half of childhood brain tumor survivors with neurocognitive problems, and are associated with worse executive functioning. Future studies should focus on the development of sleep interventions for this population, to improve sleep as well as executive functioning. K E Y W O R D S executive functioning, pediatric hematology/oncology, sleep Abbreviations: ADHD/ADD, attention deficit (hyperactivity) disorder; BRIEF, Behavior Rating Inventory of Executive Functioning; DA, disorders of arousal; CBT, cognitive behavioral therapy;

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Sleep Disorders in Children With Cancer

Cited by 63 publications

References 60 publications

Sleep Quality and Associated Risk Factors in Leukemia Patients Undergoing Chemotherapy in Iran

Sleep Quality and Associated Risk Factors in Leukemia Patients Undergoing Chemotherapy in Iran

Sleep complaints in survivors of pediatric brain tumors

High occurrence of sleep problems in survivors of a childhood brain tumor with neurocognitive complaints: The association with psychosocial and behavioral executive functioning

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