Sleep‐disordered breathing and glucose metabolism in hypertensive men: a population‐based study

Elmasry, Ahmed; Lindberg, Eva; Berne, Christian; Janson, Christer; Gíslason, Þórarinn; Tageldin, Mohamed Awad; Boman, Gunnar

doi:10.1046/j.1365-2796.2001.00787.x

Cited by 226 publications

(135 citation statements)

References 36 publications

(39 reference statements)

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“…Several studies have shown an increased prevalence of sleep apnea and sleep disordered breathing in patients with diabetes mellitus type II (62,81). Mondini and Guilleminault (82) reported increased frequency of abnormal breathing during sleep in lean and obese diabetics.…”

Section: Sleep Apnea and Diabetesmentioning

confidence: 99%

Sleep Apnea and its Association with the Stress System, Inflammation, Insulin Resistance and Visceral Obesity

Trakada

Chrousos

Pejovic

et al. 2007

Sleep Medicine Clinics

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Section: Sleep Apnea and Diabetesmentioning

confidence: 99%

Sleep Apnea and its Association with the Stress System, Inflammation, Insulin Resistance and Visceral Obesity

Trakada

Chrousos

Pejovic

et al. 2007

Sleep Medicine Clinics

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“…Obstructive sleep apnea syndrome (OSAS) is defined as repetitive decreases or cessations of airflow during sleep (1) and is associated with a wide array of cardiovascular (2) and metabolic risks (3,4), and is therefore linked to an elevated cardiovascular morbidity and mortality. Interestingly, part of the risk profile appears to be shared by patients suffering from adult GH deficiency (GHD) syndrome (5).…”

Section: Introductionmentioning

confidence: 99%

Effects of long-term continuous positive airway pressure on body composition and IGF1

Münzer

Hegglin

Stannek

et al. 2010

European Journal of Endocrinology

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Objective: To investigate the long-term effects of nasal continuous positive airway pressure (CPAP) ventilation in patients with obstructive sleep apnea syndrome (OSAS) on body composition (BC) and IGF1. Design: Observational study. Subjects: Seventy-eight (11 females and 67 males) OSAS patients who were compliant with CPAP (age 51G1.1 years) participated in the study. We assessed body mass index (BMI), total body mass (TBM), total body fat (TBF; kg) and lean body mass (LBM; kg), abdominal subcutaneous (SC) and visceral (V) fat (cm 2 ), and waist circumference (WC; cm) by magnetic resonance imaging, and IGF1 (ng/ml) before and after 7.8G1.3 months of CPAP use of an average of 5.9G1.2 h. Results: Women had a higher BMI, WC; TBM, TBF, and more SC fat. Men had a higher LBM and more V fat. CPAP increased WC (C2.8G9.6 cm, PZ0.02) and LBM (2.2G0.5 kg, PZ0.006), but not IGF1. In men, CPAP increased BMI (0.5G0.2 kg/m 2 , PZ0.02), WC (1.7G6.9 cm, PZ0.002), TBM (1.7G0.4 kg, PZ0.0001), LBM (1.5G0.4 kg, PZ0.0003), SC fat (12.9G5.1 cm 2 , PZ0.02), and IGF1 (13.6G4.2 ng/ml, PZ0.002). Compliance with CPAP increased LBM in men aged !60 years, but not in those aged O60 years, and IGF1 increased in men aged 40-60 years only. Conclusions: Long-term CPAP increased LBM in both sexes and IGF1 in men, while fat mass remained unchanged, suggesting a sexually dimorphic response of IGF1 to CPAP. The role of the GH axis activity and age to this response is unclear. The metabolic consequences of changes in LBM are still to be determined. Future studies on the effects of CPAP on BC should include LBM as an outcome.

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“…Obstructive sleep apnea (OSA) is very common in patients with type 2 diabetes (T2D) (6)(7)(8)(9)(10). We previously reported that OSA is associated with peripheral neuropathy, nephropathy, and estimated glomerular filtration rate decline in patients with T2D independently of obesity (10,11).…”

mentioning

confidence: 99%

Obstructive Sleep Apnea and Retinopathy in Patients with Type 2 Diabetes. A Longitudinal Study

Altaf

Dodson

Ali

et al. 2017

Am J Respir Crit Care Med

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Rationale: Obstructive sleep apnea (OSA) is associated with several pathophysiological deficits found in diabetic retinopathy (DR). Hence, it's plausible that OSA could play a role in the pathogenesis of sight-threatening DR (STDR).Objectives: To assess the relationship between OSA and DR in patients with type 2 diabetes and to assess whether OSA is associated with its progression.Methods: A longitudinal study was conducted in diabetes clinics within two U.K. hospitals. Patients known to have any respiratory disorder (including OSA) were excluded. DR was assessed using twofield 45-degree retinal images for each eye. OSA was assessed using a home-based multichannel cardiorespiratory device. Measurements and Main Results:A total of 230 patients were included. STDR and OSA prevalence rates were 36.1% and 63.9%, respectively. STDR prevalence was higher in patients with OSA than in those without OSA (42.9% vs. 24.1%; P = 0.004). After adjustment for confounders, OSA remained independently associated with STDR (odds ratio, 2.3; 95% confidence interval, 1.1-4.9; P = 0.04). After a median (interquartile range) follow-up of 43.0 (37.0-51.0) months, patients with OSA were more likely than patients without OSA to develop preproliferative/proliferative DR (18.4% vs. 6.1%; P = 0.02). After adjustment for confounders, OSA remained an independent predictor of progression to preproliferative/proliferative DR (odds ratio, 5.2; 95% CI confidence interval, 1.2-23.0; P = 0.03). Patients who received continuous positive airway pressure treatment were significantly less likely to develop preproliferative/proliferative DR.Conclusions: OSA is associated with STDR in patients with type 2 diabetes. OSA is an independent predictor for the progression to preproliferative/proliferative DR. Continuous positive airway pressure treatment was associated with reduction in preproliferative/proliferative DR. Interventional studies are needed to assess the impact of OSA treatment on STDR.

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Sleep‐disordered breathing and glucose metabolism in hypertensive men: a population‐based study

Cited by 226 publications

References 36 publications

Sleep Apnea and its Association with the Stress System, Inflammation, Insulin Resistance and Visceral Obesity

Sleep Apnea and its Association with the Stress System, Inflammation, Insulin Resistance and Visceral Obesity

Effects of long-term continuous positive airway pressure on body composition and IGF1

Obstructive Sleep Apnea and Retinopathy in Patients with Type 2 Diabetes. A Longitudinal Study

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