Sleep deprivation, cognitive performance, and hormone therapy in postmenopausal women

Alhola, Paula; Tallus, Maija; Kylmälä, Mervi; Portin, Raija; Polo‐Kantola, Päivi

doi:10.1097/00042192-200512020-00008

Cited by 123 publications

(143 citation statements)

References 24 publications

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“…Despite this shared neural basis of memory, attention and alertness in some target brain areas for estrogen, the possible modulating effects of estrogen on reaction times and vigilance during sleep deprivation have so far not been considered. In a recent study, no modulating effect of estrogen on visual memory and shared attention during sleep deprivation was found (Alhola et al, 2005).…”

Section: Introductionmentioning

confidence: 92%

Hormone Treatment Gives No Benefit Against Cognitive Changes Caused by Acute Sleep Deprivation in Postmenopausal Women

Karakorpi

Alhola

Urrila

et al. 2006

Neuropsychopharmacol

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The objective was to evaluate whether hormone therapy (HT) gives any benefit against the possible impairment of cognitive performance when challenged by acute sleep deprivation. Twenty postmenopausal women volunteered (age range 59-72 years, mean ¼ 64.4 years, SD ¼ 4.4): 10 HT users and 10 nonusers. Eleven young women served as a control group for the cognitive age effect (age range 20-26 years, mean age 23.1 years, SD ¼ 1.6). The subjects spent four consecutive nights at the sleep laboratory and were exposed to acute sleep deprivation of 40 h. Measures of attention (reaction speed and vigilance), alertness, and mood were administered every 2 h during the daytime and every hour during the sleep deprivation night. Postmenopausal women performed slower than young controls, whereas young controls made more errors. In HT users, the recovery night did not fully restore the performance in the simple and two-choice reaction time tasks, but in nonusers it did so. Sleep deprivation had a detrimental, yet reversible effect on vigilance in all groups. In all groups, sleepiness started to increase after 15 h of sleep deprivation and remained elevated in the morning after the recovery night. Prolonged wakefulness or HT had no effect on mood. In conclusion, sleep deprivation impaired cognitive performance in postmenopausal as well as young women. Postmenopausal women kept up their performance at the expense of reaction speed and young women at the expense of accuracy. One night was not enough for HT users to recover from sleep deprivation. Thus, HT gave no benefit in maintaining the attention and alertness during sleep deprivation.

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Section: Introductionmentioning

confidence: 92%

Hormone Treatment Gives No Benefit Against Cognitive Changes Caused by Acute Sleep Deprivation in Postmenopausal Women

Karakorpi

Alhola

Urrila

et al. 2006

Neuropsychopharmacol

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“…Given that the angular gyrus has been shown to be involved in multiple functions (Seghier, 2013) including memory retrieval and attention, the SD-induced alteration appears to be related to the decline in cognitive performance caused by sleep loss (Alhola and Polo-Kantola, 2007). Essentially, these results suggest the potential application of the new approach to studies of individual differences.…”

Section: Resultsmentioning

confidence: 94%

“…For example, sleep loss has been shown to reduce performance on a broad range of tasks (Alhola and Polo-Kantola, 2007). A recent study has showed that long-term SD significantly reduces the thalamic gray matter volume .…”

Section: Discussionmentioning

confidence: 99%

Measuring individual morphological relationship of cortical regions

Kong

Wang

Huang

et al. 2014

Journal of Neuroscience Methods

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h i g h l i g h t s• A new metric was proposed to quantify individual morphological relations of regions.• The new metric is indexed as the similarity of different morphological distributions.• We estimate the morphological distribution from individual MRI image.• The metric seemed to have potential application to individual differences studies. a r t i c l e i n f o b s t r a c tBackground: Although local features of brain morphology have been widely investigated in neuroscience, the inter-regional relations in brain morphology have rarely been investigated, especially not for individual participants. New method: In this paper, we proposed a novel framework for investigating this relation based on an individual's magnetic resonance imaging (MRI) data. The key idea was to estimate the probability density function (PDF) of local morphological features within a brain region to provide a global description of this region. Then, the inter-regional relations were quantified by calculating the similarity of the PDFs for pairs of regions based on the Kullback-Leibler (KL) divergence. Results: For illustration, we applied this approach to a pre-post intervention study to investigate the longitudinal changes in morphological relations after long-term sleep deprivation. The results suggest the potential application of this new method for studies on individual differences in brain structure.Comparison with existing methods: The current method can be employed to estimate individual morphological relations between regions, which have been largely ignored by previous studies. Conclusions: Our morphological relation metric, as a novel quantitative biomarker, can be used to investigate normal individual variability and even within-individual alterations/abnormalities in brain structure.

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“…It is also noticeable that changes in cognitive performance and sleep pattern and quality are often associated with sex hormones (23,24). These findings highlight the importance of sex hormones in sleep regulation in the menopause period in females who indicate low levels of circulating estrogen (25) and are more sensitive to deleterious effects of sleep deficit on cognitive function (26).…”

Section: Introduction and Statement Of The Problemmentioning

confidence: 86%

A Review of Protective Effects of Exercise on Cognitive Impairments Induced by Sleep Deprivation in Female Rats

Saadati

2017

Arch Neurosci

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Sleep is an important factor in memory consolidation and brain health. In addition, sleep disorder is a common complaint among females in comparison with males. In menopausal females, to relieve sleep disturbances and other menopausal symptoms, hormone therapy may be used. Furthermore, although estrogen had helpful effects on the brain performance, hormone replacement therapy augmented unfavorable cardiovascular and oncological side effects. It is implied that exercise is a powerful nonpharmacological intervention that can develop the cognitive performances. The current study used the behavioral, physiological, and molecular evidence supporting these views.

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Sleep deprivation, cognitive performance, and hormone therapy in postmenopausal women

Cited by 123 publications

References 24 publications

Hormone Treatment Gives No Benefit Against Cognitive Changes Caused by Acute Sleep Deprivation in Postmenopausal Women

Hormone Treatment Gives No Benefit Against Cognitive Changes Caused by Acute Sleep Deprivation in Postmenopausal Women

Measuring individual morphological relationship of cortical regions

A Review of Protective Effects of Exercise on Cognitive Impairments Induced by Sleep Deprivation in Female Rats

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