Sleep and Insulin-Like Growth Factors in the Cardiovascular Health Study

Shah, Neomi; Rice, Tom; Tracy, Daniel; Rohan, Thomas E.; Bůžková, Petra; Newman, Anne B.; Kaplan, Robert C.

doi:10.5664/jcsm.3260

Cited by 12 publications

(14 citation statements)

References 35 publications

(34 reference statements)

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“…Sleep patterns were controlled for in our analyses, but sleep is another modifiable factor that influences well-being which should be thoroughly considered in future research efforts. Yet, interestingly, no association was observed between altered GH/IGF-I activity and sleep patterns in elderly participants (n = 1233, mean age 77) of the Sleep Heart Health Study (SHHS) (Shah et al, 2013). Finally, this is a non-intervention, cohort study with the limitations inherent to non-experimental research and as such, a cross-sectional design does not allow for causal associations to be determined.…”

Section: Study Strengths and Limitationsmentioning

confidence: 95%

Mind over hormones; Sex differences in associations of well-being with IGF-I, IGFBP-3 and physical activity in the KORA-Age study

Emeny

Bidlingmaier

Lacruz

et al. 2014

Experimental Gerontology

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Section: Study Strengths and Limitationsmentioning

confidence: 95%

Mind over hormones; Sex differences in associations of well-being with IGF-I, IGFBP-3 and physical activity in the KORA-Age study

Emeny

Bidlingmaier

Lacruz

et al. 2014

Experimental Gerontology

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“…Decreased serum levels of IGFBP-3 have been associated with increased risk of CVD, including coronary artery disease and CVD mortality [ 19 , 20 ]. In children with OSA, serum levels of IGFBP-3 may be decreased and be associated with growth retardation, while no association of this protein with OSA has been shown in the elderly [ 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Serum Levels of Vascular Endothelial Growth Factor and Insulin-like Growth Factor Binding Protein-3 in Obstructive Sleep Apnea Patients: Effect of Continuous Positive Airway Pressure Treatment

Archontogeorgis

Nena

Παπάνας

et al. 2015

TOCMJ

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Background and Aim:Hypoxia, a major feature of obstructive sleep apnea (OSA), modifies Vascular Endothelial Growth Factor (VEGF) and Insulin-like Growth Factor Binding Protein-3 (IGFBP-3) levels, which contribute to atherogenesis and occurrence of cardiovascular (CV) events. We assessed and compared serum levels of VEGF and IGFBP-3 in newly diagnosed OSA patients and controls, to explore associations with anthropometric and sleep parameters and to study the effect of continuous positive airway pressure (CPAP) treatment on these levels.Materials and Methods:Serum levels of VEGF and IGFBP-3 were measured in 65 OSA patients and 31 age- and body mass index- matched controls. In OSA patients, measurements were repeated after 6 months of CPAP therapy. All participants were non-smokers, without any comorbidities or systemic medication use.Results:At baseline, serum VEGF levels in OSA patients were higher compared with controls (p<0.001), while IGFBP-3 levels were lower (1.41±0.56 vs. 1.61±0.38 μg/ml, p=0.039). VEGF levels correlated with apnea-hypopnea index (r=0.336, p=0.001) and oxygen desaturation index (r=0.282, p=0.007). After 6 months on CPAP treatment, VEGF levels decreased in OSA patients (p<0.001), while IGFBP-3 levels increased (p<0.001).Conclusion:In newly diagnosed OSA patients, serum levels of VEGF are elevated, while IGFBP-3 levels are low. After 6 months of CPAP treatment these levels change. These results may reflect an increased CV risk in untreated OSA patients, which is ameliorated after CPAP therapy.

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“…A previous study in older patients showed no association between objective sleep parameters and IGF-1, but daytime sleepiness was not analyzed [17]. Our study is the first to analyze objective daytime sleepiness by MSLT and measured IGF-1.…”

Section: Discussionmentioning

confidence: 62%

“…Data about the link between OSA and IGF-1 level are variable and seem to depend on the age of the population studied. In older patients, OSA did not appear to adversely influence the GH/IGF axis, contrary to what is reported in younger patients [17]. Indeed, in younger but obese patients, the positive association between low IGF-1 levels and OSA is well-established [15].…”

Section: Discussionmentioning

confidence: 99%

“…Sleep disorders and OSA may affect the Growth Hormone/Insulin like growth factor 1 (GH/IGF-1) axis with an inverse relationship between IGF-1 plasma concentration and the severity of OSA, which could be the mechanism involved in the association between OSA and IR [15,16]. Considering the influence of age on the GH/IGF-1 axis, a previous study has focused on the relationship between sleep, OSA and GH/IGF-1 in older subjects [17] but showed no significant relationship. To account for the influence of age on IGF-1 axis, an age-adjusted IGF-1 score has previously been proposed [18]; the second objective of this study was to analyze the association between sleep parameters and this age-adjusted IGF-1 score, to determine whether this is the mechanism underlying the association between OSA and IR.…”

Section: Introductionmentioning

confidence: 99%

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Relationship between sleep parameters, insulin resistance and age-adjusted insulin like growth factor-1 score in non diabetic older patients

et al. 2017

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BackgroundSleep complaints are prevalent in older patients. Sleepiness, short or long sleep duration and obstructive sleep apnea (OSA) are associated with insulin resistance (IR). These parameters have not yet been considered together in the same study exploring the possible association between IR and sleep in older patients. IR is involved in cardiovascular and metabolic diseases, pathologies which are highly prevalent in older patients. Here we assess, in older non-diabetic patients with sleep complaints, the associations between IR and sleep parameters objectively recorded by polysomnography (PSG) rather than self-report. The Growth Hormone/Insulin like growth factor-1 axis could play a role in the development of IR during sleep disorders. The second objective of this study was to analyze the association between sleep parameters and age-adjusted IGF-1 score, which could explain the association between OSA and IR.Methods72 non-diabetic older patients, mean age 74.5 ± 7.8 years, were included in this observational study. We evaluated anthropometric measures, subjective and objective sleepiness, polysomnography, Homeostatic Model Assessment for IR (HOMA-IR) and age-adjusted IGF-1 score. A multivariate regression was used to determine factors associated with HOMA-IR.ResultsThe 47 OSA patients were over-weight but not obese and had higher IR than the non-OSA patients. In multilinear regression analysis, apnea-hypopnea index was independently associated with IR after adjustment for several confounding factors. Neither IGF-1 level nor IGF-1 score were different in the two groups.ConclusionsWe demonstrate that in non-diabetic older patients with sleep complaints, OSA is independently associated with IR, regardless of anthropometric measurements and sleep parameters (sleep duration/sleepiness/arousals). Targeting OSA to reduce IR could be useful in the elderly, although further exploration is required.

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Sleep and Insulin-Like Growth Factors in the Cardiovascular Health Study

Cited by 12 publications

References 35 publications

Mind over hormones; Sex differences in associations of well-being with IGF-I, IGFBP-3 and physical activity in the KORA-Age study

Mind over hormones; Sex differences in associations of well-being with IGF-I, IGFBP-3 and physical activity in the KORA-Age study

Serum Levels of Vascular Endothelial Growth Factor and Insulin-like Growth Factor Binding Protein-3 in Obstructive Sleep Apnea Patients: Effect of Continuous Positive Airway Pressure Treatment

Relationship between sleep parameters, insulin resistance and age-adjusted insulin like growth factor-1 score in non diabetic older patients

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