Sleep and hippocampal neurogenesis: Implications for Alzheimer’s disease

Kent, Brianne A.; Mistlberger, Ralph E.

doi:10.1016/j.yfrne.2017.02.004

Cited by 46 publications

(31 citation statements)

References 289 publications

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“…In particular, Alzheimer's disease might be well suited for the employment of both sleep and epigenetic interventions to alleviate cognitive impairment. Patients with Alzheimer's disease show altered levels of epigenetic markers in the hippocampus ; various sleep disruptions including nighttime sleep fragmentation, increased daytime napping, and less time spent in slow wave and REM sleep stages ; and impairments in DG neurogenesis . These findings suggest that cognitive deficits in Alzheimer's disease could result in part from disruptions in DG neurogenesis caused by both suboptimal epigenetic modification of gene expression and poor sleep.…”

Section: Targeting Sleep and Epigenetic Markers As Treatment Strategiesmentioning

confidence: 99%

Concise Review: Regulatory Influence of Sleep and Epigenetics on Adult Hippocampal Neurogenesis and Cognitive and Emotional Function

et al. 2018

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Neural stem and progenitor cells continue to generate new neurons in particular regions of the brain during adulthood. One of these neurogenic regions is the dentate gyrus (DG) of the hippocampus, which plays an important role in cognition and emotion. By exploiting this innate neuronal regeneration mechanism in the DG, new technologies have the potential to promote resistance to or recovery from brain dysfunction or degeneration. However, a deeper understanding of how adult DG neurogenesis is regulated by factors such as sleep and epigenetic modifications of gene expression could lead to further breakthroughs in the clinical application of neural stem and progenitor cells. In this review, we discuss the functions of adult-born DG neurons, describe the epigenetic regulation of adult DG neurogenesis, identify overlaps in how sleep and epigenetic modifications impact adult DG neurogenesis and memory consolidation, and suggest ways of using sleep or epigenetic interventions as therapies for neurodegenerative and psychiatric disorders. By knitting together separate strands of the literature, we hope to trigger new insights into how the functions of adult-generated neurons are directed by interactions between sleep-related neural processes and epigenetic mechanisms to facilitate novel approaches to preventing and treating brain disorders such as depression, post-traumatic stress disorder, and Alzheimer's disease. STEM CELLS 2018; 00:000-000 SIGNIFICANCE STATEMENTNew technologies utilizing neural stem cells in the adult hippocampus could potentially be used to promote innate resistance to or recovery from brain dysfunction or degeneration. Accumulating evidence indicates that adult hippocampal neurogenesis contributes to cognitive and emotional processing and is regulated by sleep and epigenetic modification of gene expression. Therefore, a richer understanding of how the interplay between sleep and epigenetics impacts adult hippocampal neurogenesis and thereby influences hippocampal function can help advance efforts to employ behavioral sleep interventions, epigenetic drugs, and novel neural stem cell-based therapeutic strategies for preventing or treating neurodegenerative and psychiatric disorders.

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Section: Targeting Sleep and Epigenetic Markers As Treatment Strategiesmentioning

confidence: 99%

Concise Review: Regulatory Influence of Sleep and Epigenetics on Adult Hippocampal Neurogenesis and Cognitive and Emotional Function

et al. 2018

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“…Aging is a complex molecular process that is associated with many life-threatening diseases, such as neurodegenerative disease, diabetes, and cardiovascular disease [1, 2]. The hippocampus is the most vulnerable region in the central nervous system (CNS), as it can be severely affected by the aging process [3]; neurodegeneration can be induced in the hippocampus and can result in cognitive dysfunction, which has a close relationship with the pathological progression of Alzheimer's disease and markedly decreases quality of life [4–6]. Various drugs have been developed to ameliorate neurodegenerative diseases.…”

Section: Introductionmentioning

confidence: 99%

Ethanol Extract of Centipeda minima Exerts Antioxidant and Neuroprotective Effects via Activation of the Nrf2 Signaling Pathway

Wang

Hao

et al. 2019

Oxidative Medicine and Cellular Longevity

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Oxidative stress is implicated in the pathogenesis of neurodegeneration and other aging-related diseases. Previous studies have found that the whole herb of Centipeda minima has remarkable antioxidant activities. However, there have been no reports on the neuroprotective effects of C. minima, and the underlying mechanism of its antioxidant properties is unclear. Here, we examined the underlying mechanism of the antioxidant activities of the ethanol extract of C. minima (ECM) both in vivo and in vitro and found that ECM treatment attenuated glutamate and tert-butyl hydroperoxide (tBHP)-induced neuronal death, reactive oxygen species (ROS) production, and mitochondria dysfunction. tBHP-induced phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK) and c-Jun N-terminal kinases (JNK) was reduced by ECM, and ECM sustained phosphorylation level of extracellular signal regulated kinase (ERK) in SH-SY5Y and PC12 cells. Moreover, ECM induced the activation of nuclear factor erythroid 2-related factor 2 (Nrf2) and the upregulation of phase II detoxification enzymes, including heme oxygenase-1 (HO-1), superoxide dismutase-2 (SOD2), and NAD(P)H quinone oxidoreductase-1 (NQO-1) in both two cell types. In a D-galactose (D-gal) and aluminum muriate (AlCl3)-induced neurodegenerative mouse model, administration of ECM improved the learning and memory of mice in the Morris water maze test and ameliorated the effects of neurodegenerative disorders. ECM sustained the expression level of postsynaptic density 95 (PSD95) and synaptophysin (SYN), activated the Nrf2 signaling pathway, and restored the levels of cellular antioxidants in the hippocampus of mice. In addition, four sesquiterpenoids were isolated from C. minima to identify the bioactive components responsible for the antioxidant activity of C. minima; 6-O-angeloylplenolin and arnicolide D were found to be the active compounds responsible for the activation of the Nrf2 signaling pathway and inhibition of ROS production. Our study examined the mechanism of C. minima and its active components in the amelioration of oxidative stress, which holds the promise for the treatment of neurodegenerative disease.

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“…Finally, other negative consequences of disordered sleep have been studied, such as increases in neuronal oxidative stress, impairment in the blood-brain barrier and reduction in the hippocampal neurogenesis 62 . In Figure 2 we show a diagram with the proposed causal mechanisms.…”

Section: Potential Mechanisms Linking Sleep Disorders and Ad Riskmentioning

confidence: 99%

Alzheimer's disease and sleep disturbances: a review

Borges

Poyares

Piovezan

et al. 2019

Arq. Neuro-Psiquiatr.

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The association between Alzheimer's disease (AD) and sleep disturbances has received increasing scientific attention in the last decades. However, little is known about the impact of sleep and its disturbances on the development of preclinical AD stages, such as mild cognitive impairment. This review describes the evolution of knowledge about the potential bidirectional relationships between AD and sleep disturbances exploring recent large prospective studies and meta-analyses and studies of the possible mechanisms through which sleep and the neurodegenerative process could be associated. The review also makes a comprehensive exploration of the sleep characteristics of older people, ranging from cognitively normal individuals, through patients with mild cognitive impairment, up to the those with dementia with AD.

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Sleep and hippocampal neurogenesis: Implications for Alzheimer’s disease

Cited by 46 publications

References 289 publications

Concise Review: Regulatory Influence of Sleep and Epigenetics on Adult Hippocampal Neurogenesis and Cognitive and Emotional Function

Concise Review: Regulatory Influence of Sleep and Epigenetics on Adult Hippocampal Neurogenesis and Cognitive and Emotional Function

Ethanol Extract of Centipeda minima Exerts Antioxidant and Neuroprotective Effects via Activation of the Nrf2 Signaling Pathway

Alzheimer's disease and sleep disturbances: a review

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