Journal of Cell Biology volume 217, issue 4, P1411-1429 2018 DOI: 10.1083/jcb.201707027 View full text
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Maria Yurchenko, Astrid Skjesol, Liv Ryan, Gabriel Mary Richard, Richard Kumaran Kandasamy, Ninghai Wang, Cox Terhorst, Harald Husebye, Terje Espevik

Abstract: Yurchenko et al. discover that the Ig-like receptor molecule SLAMF1 enhances production of type I interferon induced by Gram-negative bacteria through modulation of MyD88-independent TLR4 signaling. This makes SLAMF1 a potential target for controlling inflammatory responses against Gram-negative bacteria.