Skin Ulcers Associated With a Tender and Swollen Arm

Schaen, Lori; Sheth, Anita P.

doi:10.1001/archderm.134.9.1145-b

Cited by 20 publications

(2 citation statements)

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“…By the early 1980s, the entity of CMO was clearly gaining recognition [9][10][11]. Table 1 details many of the terminologies which were probably described as synonyms of CMO [4,6,12,13]. A retrospective view of reports using any of these proposed synonyms illustrates clinical, radiological, and other features which were highly similar.…”

Section: Historical Aspectsmentioning

confidence: 99%

“…One case report noted possible progression to B cell lymphoma [60], while another report found CMO to evolve after completing treatment for acute lymphocytic leukemia [61]. Table 3 outlines several associations of CMO with other disease entities [12,13,18,23,39,47,56,[62][63][64][65][66][67][68][69][70][71][72][73][74][75][76][77][78][79][80]. Many of these associations are inclusive of entities which would be considered by many to be immune phenomena.…”

Section: Clinical Characteristicsmentioning

confidence: 99%

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Chronic multifocal osteomyelitis: Is infectious causation a moot point?

Cimolai

2011

Journal of Infection and Public Health

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Chronic multifocal osteomyelitis (CMO) is an uncommon disease entity with descriptions possibly emanating from the medical literature over one century ago, and there are numerous disease entities which have been historically detailed and which are probably synonymous. The illness is one of chronicity with exacerbating and remitting focal bony lesions. The differential diagnosis for a bony lesion which ultimately proves to be CMO is initially quite broad. There is no absolute pathognomonic clinical finding, and the diagnosis is highly dependent on clinical course, histopathology, and an absence of microbial infection. Recent studies have focused on immune dysfunction or dysregulation, and there are now many other diseases which are inflammatory in nature and which have been diagnosed among patients with CMO. Despite the aforementioned, the potential for direct infectious causation or indirect causation by infectious stimulation of immunity cannot be entirely excluded. Infection as a mechanism for pathogenesis must continue to be entertained. Multi-centre studies are key to future research.

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