Skin toxicity from external beam radiation therapy in breast cancer patients: protective effects of Resveratrol, Lycopene, Vitamin C and anthocianin (Ixor®)

Franco, Rossella Di; Calvanese, Maria Grazia; Murino, Paola; Manzo, Roberto; Guida, Cesare; Gennaro, Davide Di; Anania, Caterina; Ravo, Vincenzo

doi:10.1186/1748-717x-7-12

Cited by 42 publications

(26 citation statements)

References 20 publications

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“…In a study in human patients of breast cancer, the effect of dietary supplements based on RSV, lycopene, vitamin C and anthocyanins (Ixor ® ) in reducing skin toxicity, due to external beam XRT directed to the breast, was evaluated (Di Franco et al, 2012). In this study, all enrolled patients underwent conservative surgery (quadrantectomy), and the patients were subjected to adjuvant radiation treatment with 6 MV photons, with a dose of 50 Gy (2 Gy/fraction) directed to whole breast, and a subsequent additional dose of 10 Gy (2 Gy/fraction) directed to original tumour site.…”

Section: Breast Cancermentioning

confidence: 99%

Synergistic Effect of Resveratrol and Radiotherapy in Control of Cancers

Kma

2013

Asian Pacific Journal of Cancer Prevention

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Cancers will continue to be a threat to health unless they can be controlled by combinations of treatment modalities. In this review, evaluate the role of resveratrol (RSV) as a radiosensitizing agent was evaluated and underlying mechanisms holistically explored in different cancer models focusing on therapeutic possibilities. The ability of RSV to modify the effect of radiation exposure in normal and cancer cells has indeed been shown quite convincingly, the combination of RSV and IR exhibiting synergistic effects on different cancer cells. This is relevant since controlled exposure to IR is one of the most frequently applied treatments in cancer patients. However, radiotherapy (XRT) treatment regimes are very often not effective in clinical practice as observed in patients with glioma, prostate cancer (PCa), melanoma, for example, largely due to tumour radioresistant properties. Sensitization of IR-induced apoptosis by natural products such as RSV is likely to be relevant in cancer control and treatment. However, all cancers do not respond to RSV+IR in a similar manner. Therefore, for those such as the radioresistant PCa or melanoma cells, the RSV+IR regime has to be very carefully chosen in order to achieve effective and desirable outcomes with minimum toxicity to normal cells. They are reports that the highest concentration of 100 mM RSV and highest dose of 5 Gy IR are sufficient to kill cells by induction of apoptosis, indicating that RSV is effective in radiosensitizing otherwise radioresistant cells. In general, it has been shown in different cancer cells that RSV+XRT effectively act by enhancing expression of anti-proliferative and pro-apoptotic molecules, and inhibiting pro-proliferative and anti-apoptotic molecules, leading to induction of apoptosis through various pathways, and cell death. If RSV+XRT can suppress the signature of cancer stemness, enhance the radiosensitivity by either targeting the mitochondrial functionality or modulating the tumour necrosis factor-mediated or Fas-FasL-mediated pathways of apoptosis in different cancers, particularly in vivo, its therapeutic use in the control of cancers holds promise in the near future.

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Section: Breast Cancermentioning

confidence: 99%

Synergistic Effect of Resveratrol and Radiotherapy in Control of Cancers

Kma

2013

Asian Pacific Journal of Cancer Prevention

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“…These compounds were used at a dose of two tablets a day, starting from 10 days before the radiotherapy until 10 days after the end of treatment. 38 The studies of Zhang et al 39 demonstrated anticancer activities of tea epigallocatechin-3-gallate in breast cancer patients under radiotherapy. 43 At present, A. melanocarpa fruits are used for syrup, jam, juice, jellies, tea, wine, liqueur, and commercial extract (Aronox ® by Agropharm (Poland)) production.…”

Section: Dietary Antioxidants and Their Role In Cancermentioning

confidence: 98%

Role of Black Chokeberries in Breast Cancer

Olas

2014

Cancer

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“…Moreover, it was used to reduce skin toxicity secondary to chemoradiation in patients with breast cancer [110,[116][117][118]. However, skin photoprotective effects determined by erythema, were only observed following at least 10 weeks of oral supplementation of several carotene including lycopene [60,112,114,[119][120][121][122][123].…”

Section: Can Skin Redox Balance Be Efficiently Affected By Exogenous mentioning

confidence: 99%

Skin Redox Balance Maintenance: The Need for an Nrf2-Activator Delivery System

et al. 2016

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Abstract:The skin, being the largest organ of the body, functions as a barrier between our body and the environment. It is consistently exposed to various exogenous and endogenous stressors (e.g., air pollutants, ionizing and non-ionizing irradiation, toxins, mitochondrial metabolism, enzyme activity, inflammatory process, etc.) producing reactive oxygen species (ROS) and physical damage (e.g., wounds, sunburns) also resulting in reactive oxygen species production. Although skin is equipped with an array of defense mechanisms to counteract reactive oxygen species, augmented exposure and continued reactive oxygen species might result in excessive oxidative stress leading to many skin disorders including inflammatory diseases, pigmenting disorders and some types of cutaneous malignancy. The nuclear factor erythroid 2-related factor 2 (Nrf2) is an emerging regulator of cellular resistance and of defensive enzymes such as the phase II enzymes. Induction of the Keap1-Nrf2 pathway may have a beneficial effect in the treatment of a large number of skin disorders by stimulating an endogenous defense mechanism. However, prolonged and enhanced activation of this pathway is detrimental and, thus, limits the therapeutic potential of Keap1-Nrf2 modulators. Here, we review the consequences of oxidative stress to the skin, and the defense mechanisms that skin is equipped with. We describe the challenges of maintaining skin redox balance and its impact on skin status and function. Finally, we suggest a novel strategy for maintenance of skin redox homeostasis by modulating the Keap1-Nrf2 pathway using nanotechnology-based delivery systems.

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Skin toxicity from external beam radiation therapy in breast cancer patients: protective effects of Resveratrol, Lycopene, Vitamin C and anthocianin (Ixor®)

Cited by 42 publications

References 20 publications

Synergistic Effect of Resveratrol and Radiotherapy in Control of Cancers

Synergistic Effect of Resveratrol and Radiotherapy in Control of Cancers

Role of Black Chokeberries in Breast Cancer

Skin Redox Balance Maintenance: The Need for an Nrf2-Activator Delivery System

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