2007
DOI: 10.1080/10428190601137336
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Abstract: Cutaneous lesions occur in up to 25% of patients with chronic lymphocytic leukemia (CLL). These can be caused by either cutaneous seeding by leukemic cells (leukemia cutis, LC) and other malignant diseases or nonmalignant disorders. Skin infiltration with B-lymphocyte CLL manifests as solitary, grouped, or generalized papules, plaques, nodules, or large tumors. Prognosis in CLL patients with LC is rather good and many authors claim that it does not significantly affect patients' survival. However, prognosis is… Show more

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Cited by 144 publications
(192 citation statements)
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“…120 Paraneoplastic pemphigus is characterized by painful mucosal lesions as well as a polymorphic rash that is seen mainly on the palms, soles, and trunk. 107 The syndrome is thought to arise from antibodies directed against tumor antigens that exhibit cross-reactivity against various epidermal proteins. 100 Paraneoplastic pemphigus is typically seen in conjunction with B-cell lymphoproliferative disorders.…”
Section: Acanthosis Nigricansmentioning
confidence: 99%
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“…120 Paraneoplastic pemphigus is characterized by painful mucosal lesions as well as a polymorphic rash that is seen mainly on the palms, soles, and trunk. 107 The syndrome is thought to arise from antibodies directed against tumor antigens that exhibit cross-reactivity against various epidermal proteins. 100 Paraneoplastic pemphigus is typically seen in conjunction with B-cell lymphoproliferative disorders.…”
Section: Acanthosis Nigricansmentioning
confidence: 99%
“…100 Paraneoplastic pemphigus is typically seen in conjunction with B-cell lymphoproliferative disorders. 107 Treatment includes immune-modulating agents such as corticosteroids and rituximab, as well as cancer-directed therapy. 100 Sweet Syndrome Approximately 20% of patients with Sweet syndrome have an underlying cancer, most commonly acute myeloid leukemia or another hematologic malignancy.…”
Section: Acanthosis Nigricansmentioning
confidence: 99%
“…Dear Editor B-cell chronic lymphocytic leukemia (B-CLL) is the most common adult leukemia in Western countries with annual incidence rate 3-5 cases per 100 000 [1]. Skin lesions in patients with CLL may represent nonspecific manifestations related to the impaired immune system or specific skin involvement, known as leukemia cutis (LC).…”
mentioning
confidence: 99%
“…Skin lesions in patients with CLL may represent nonspecific manifestations related to the impaired immune system or specific skin involvement, known as leukemia cutis (LC). The presence of LC varies from the type of leukemia, but in patients with B-CLL is far less common comparing to T-cell leukemia [1,2]. The limited literature [2][3][4][5][6][7][8] shows that LC usually appears later in the course of the disease, after the symptoms of fatigue, night sweats, weight loss, easy bruising, heapatosplenomegaly and enlarged lymph nodes.…”
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confidence: 99%
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