Skin interaction, permeation, and toxicity of silica nanoparticles: Challenges and recent therapeutic and cosmetic advances

Morais, Renata Pinho; Hochheim, Sabrina; Oliveira, Carolina Camargo de; Riegel‐Vidotti, Izabel C.; Marino, Cláudia Eliana Bruno

doi:10.1016/j.ijpharm.2021.121439

Cited by 30 publications

(12 citation statements)

References 213 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They can improve cosmetic products’ texture, effectiveness, and shelf-life and act as an anti-caking agent. Moreover, they have high photostability and protect against UV radiation [ 253 ].…”

Section: Peptide Delivery Systemsmentioning

confidence: 99%

Food Peptides for the Nutricosmetic Industry

Dini

Mancusi

2023

Antioxidants

View full text Add to dashboard Cite

In recent years, numerous reports have described bioactive peptides (biopeptides)/hydrolysates produced from various food sources. Biopeptides are considered interesting for industrial application since they show numerous functional properties (e.g., anti-aging, antioxidant, anti-inflammatory, and antimicrobial properties) and technological properties (e.g., solubility, emulsifying, and foaming). Moreover, they have fewer side effects than synthetic drugs. Nevertheless, some challenges must be overcome before their administration via the oral route. The gastric, pancreatic, and small intestinal enzymes and acidic stomach conditions can affect their bioavailability and the levels that can reach the site of action. Some delivery systems have been studied to avoid these problems (e.g., microemulsions, liposomes, solid lipid particles). This paper summarizes the results of studies conducted on biopeptides isolated from plants, marine organisms, animals, and biowaste by-products, discusses their potential application in the nutricosmetic industry, and considers potential delivery systems that could maintain their bioactivity. Our results show that food peptides are environmentally sustainable products that can be used as antioxidant, antimicrobial, anti-aging, and anti-inflammatory agents in nutricosmetic formulations. Biopeptide production from biowaste requires expertise in analytical procedures and good manufacturing practice. It is hoped that new analytical procedures can be developed to simplify large-scale production and that the authorities adopt and regulate use of appropriate testing standards to guarantee the population’s safety.

show abstract

Section: Peptide Delivery Systemsmentioning

confidence: 99%

Food Peptides for the Nutricosmetic Industry

Dini

Mancusi

2023

Antioxidants

View full text Add to dashboard Cite

show abstract

“…NMs are widely used in many fields, such as cosmetics, urging the understanding of their potential toxicity. The increase of new NPs is unfortunately not accompanied by their safety assessment [55,56]. NMs unique properties, such as size, surface area, zeta potential, and aggregation, have influence over the biological reaction and can be a risk for the consumer, thus it is important to increase the knowledge regarding the potential toxicology of NPs supported by in vivo or in vitro studies [34,57].…”

Section: Safety Assessment Testing To Evaluate Different Types Of Tox...mentioning

confidence: 99%

Safety Assessment of Nanomaterials in Cosmetics: Focus on Dermal and Hair Dyes Products

Coimbra

Sousa-Oliveira²,

Ferreira-Faria³

et al. 2022

Cosmetics

View full text Add to dashboard Cite

Nanomaterials use in cosmetics is markedly enhancing, so their exposure and toxicity are important parameters to consider for their risk assessment. This review article provides an overview of the active cosmetic ingredients used for cosmetic application, including dermal cosmetics and also hair dye cosmetics, as well as their safety assessment, enriched with a compilation of the safety assessment tests available to evaluate the different types of toxicity. In fact, despite the increase in research and the number of papers published in the field of nanotechnology, the related safety assessment is still insufficient. To elucidate the possible effects that nanosized particles can have on living systems, more studies reproducing similar conditions to what happens in vivo should be conducted, particularly considering the complex interactions of the biological systems and active cosmetic ingredients to achieve newer, safer, and more efficient nanomaterials. Toward this end, ecological issues and the toxicological pattern should also be a study target.

show abstract

“…The excellent properties of sanshool, including its photoprotective and antioxidative abilities, could be attributed to the three special conjugated long fatty chain-containing conjugated double bonds . However, like most highly reactive molecules, sanshool has inherent limitations, including decomposition reactions under irradiation, easy deactivation, its difficulty in being recycled, and skin permeation concerns that hinder its application in the prevention and treatment of skin photodamage. − Therefore, the search for new strategies to enhance the stability of sanshool’s photoprotective and antioxidative properties is expected to further expand the applications of sanshool in biomedical fields related to skin photodamage and oxidative stress diseases.…”

Section: Introductionmentioning

confidence: 99%

Melanin-like Nanoparticles Boosted the Photoprotective Efficiency and Stability of Sanshool

Guo

Wang

et al. 2023

Chem. Mater.

View full text Add to dashboard Cite

Sanshool, a naturally occurring molecule from Zanthoxylum xanthoxylum, is an essential component preventing photodamage; however, inherent instabilities and the potential risk of skin permeation limit its further application. Inspired by the natural photoprotective mechanism, melanin-like materials were applied to boost the photoprotective efficiency and stability of sanshool. This could be achieved with melanin−sanshool nanoparticles (melanin−S NPs) via facile and efficient boron esterification interactions, yielding melanin− S NPs with uniform sizes and improving stability, effective ultraviolet absorption, and antioxidative capacities in vitro. In addition, the skin permeation, photoprotective activity, and potential mechanism of melanin−S NPs were studied using skin photodamage intracellular and animal models. This bioinspired strategy of melanin-based nanomaterials provides a platform for improving the key properties of naturally occurring functional molecules.

show abstract

Skin interaction, permeation, and toxicity of silica nanoparticles: Challenges and recent therapeutic and cosmetic advances

Cited by 30 publications

References 213 publications

Food Peptides for the Nutricosmetic Industry

Food Peptides for the Nutricosmetic Industry

Safety Assessment of Nanomaterials in Cosmetics: Focus on Dermal and Hair Dyes Products

Melanin-like Nanoparticles Boosted the Photoprotective Efficiency and Stability of Sanshool

Contact Info

Product

Resources

About