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Cited by 739 publications
(963 citation statements)
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References 30 publications
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“…The signature genes of “tissue‐resident” memory T cells are also expressed by bone marrow‐resident memory T cells 151. That “tissue‐resident” memory T cells are indeed resident, ie, do not circulate, has been suggested by parabiosis experiments 164. For human “tissue‐resident” memory T cells of the skin, it has been argued that CCR7‐negative cells are residents of the skin, since they are refractory towards treatment with anti‐CD52 (Alamtuzumab), depleting circulating memory T cells, including CCR7‐expressing memory T cells of the skin 165.…”
Section: “Tissue‐resident” Vs Bone Marrow‐resident Memory T Lymphocytesmentioning
confidence: 99%
“…The signature genes of “tissue‐resident” memory T cells are also expressed by bone marrow‐resident memory T cells 151. That “tissue‐resident” memory T cells are indeed resident, ie, do not circulate, has been suggested by parabiosis experiments 164. For human “tissue‐resident” memory T cells of the skin, it has been argued that CCR7‐negative cells are residents of the skin, since they are refractory towards treatment with anti‐CD52 (Alamtuzumab), depleting circulating memory T cells, including CCR7‐expressing memory T cells of the skin 165.…”
Section: “Tissue‐resident” Vs Bone Marrow‐resident Memory T Lymphocytesmentioning
confidence: 99%
“…The concept of tissue-resident memory CD8 + T-cells is now established for several types of tissues and infections [84][85][86][87] . Indeed, PD-1 positive CD8 + T-cells have been found to be preferentially retained in bone marrow, lymph nodes, kidney, and brain after chronic LCMV clone-13 infection 42 .…”
Section: Pd-1 and Other Inhibitory Receptors Enable A Functional Contmentioning
confidence: 99%
“…Upon resolution of infection, there remains a population of CD8 T cells that differentiates in situ from KLRG1 2 effectors to form a longlived population of tissue-resident memory T (T RM ) cells (2)(3)(4). These T RM cells provide immediate local immunity (2,5,6) and, therefore, their generation holds promise for novel vaccines against pathogens that target barrier tissues, such as skin and mucosa. Although some aspects of peripheral memory formation were determined recently, such as the contributions of the cytokines TGF-b and IL-15 (3,4,7), the molecular mechanisms regulating early effector T cell retention as a prerequisite for subsequent T RM cell differentiation are not fully understood.…”
mentioning
confidence: 99%