Skin infection caused by <i>Scedosporium apiospermum</i>

Karaarslan, Aydın; Arıkan, Sevtap; Karaarslan, Filiz; Çetin, E.

doi:10.1046/j.0933-7407.2003.00926.x

Cited by 17 publications

(10 citation statements)

References 16 publications

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“…An interdigital case was reported by Karaarslan et al . [193]. Cases of asymptomatic soft tissue abscess without sinus drainage were reported in immunosuppresssed [194] and also in previously healthy subjects [195,196].…”

Section: Characteristics Of Diseasementioning

confidence: 94%

Scedosporium apiospermum: changing clinical spectrum of a therapy-refractory opportunist*

et al. 2006

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Section: Characteristics Of Diseasementioning

confidence: 94%

Scedosporium apiospermum: changing clinical spectrum of a therapy-refractory opportunist*

et al. 2006

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“…Risk factors for scedosporiosis include: CF, [254][255][256] severe immunosuppression, 241 hematological malignancy (especially with neutropenia), 254,[257][258][259] OTR, 14,55,72,241,245,254,257,[260][261][262] HIV/ acquired immune deficiency syndrome (AIDS), 263,264 and near drowning. 265 Scedosporium rarely affects healthy individuals 266,267 but bone/joint, 268,269 ear, 270,271 and SSTI 272 have been reported in immunocompetent persons following trauma, surgery, or inoculation injury 241,257,269 or near drowning. [273][274][275][276][277]…”

Section: Risk Factors For Scedosporiosismentioning

confidence: 99%

Fungal Infections Complicating Lung Transplantation

Clark

Weigt

Fishbein³

et al. 2018

Semin Respir Crit Care Med

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Lung transplantation is an increasingly utilized modality for treating advanced lung disease. However, lung transplant recipients (LTRs) experience high rates of infection-related mortality and, compared with other solid organ transplant recipients, are at increased risk of infectious complications given the intensity of immunosuppression employed, the presence of airway abnormalities after surgery and exposure of the allograft to the environment. Fungal infections, particularly mold infections, are problematic after transplantation as they are often associated with limited treatment options and poor outcomes. We describe the non- fungal infections occurring in LTRs, including their epidemiology, clinical features, and treatment.

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“…Infections were described more commonly in immunosuppressed patients (3-5, 7, 9, 13, 17, 21, 23, 25, 27, 28, 30-32, 35, 38, 41, 42, 46) but also occurred in immunocompetent patients (20,21,26,40,43,44). Cases have been reported to occur secondary to inoculation from environmental sources (21,40), after medical procedures such as surgery or intravenous catheter placement (5,26), and in the absence of identifiable trauma.…”

mentioning

confidence: 99%

Scedosporium apiospermumSoft Tissue Infection Successfully Treated with Voriconazole: Potential Pitfalls in the Transition from Intravenous to Oral Therapy

Schaenman¹,

DiGiulio

Mirels

et al. 2005

J Clin Microbiol

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An immunocompromised patient with an invasive soft tissue infection due to Scedosporium apiospermum was successfully treated with voriconazole and surgical debridement. After transition from intravenous to oral therapy, successive adjustments of the oral dose were required to achieve complete resolution. For soft tissue infections due to molds characterized by thin, septate hyphae branching at acute angles, voriconazole should be considered a first-line antifungal agent. The potential usefulness of plasma voriconazole levels for guiding optimal therapy should be investigated. CASE REPORTA 58-year-old woman who had been treated chronically for Behçet's disease with prednisone, at doses ranging from 10 to 40 mg per day over 10 years, developed pain, swelling, and erythema of the left wrist. These symptoms were felt by her rheumatologist to represent an unusually severe exacerbation of arthritis, and a single dose of infliximab at 3 mg/kg was given intravenously. In addition, prednisone was increased from 20 to 100 mg per day, and amoxicillin-clavulanic acid at 875 mg twice daily was empirically started. Due to continued pain and erythema, the patient underwent exploratory surgery of her left wrist 10 days later at a local community hospital. Intraoperatively, thickening and early mucinous degeneration of the tenosynovium of an extensor tendon was noted from the wrist to the distal end of the third metacarpal. Surgically obtained tissue grew rare methicillin-sensitive Staphylococcus aureus but was negative for fungi and mycobacteria based on both cultures and histopathology. Antibiotic therapy was changed from oral amoxicillin-clavulanic acid to intravenous oxacillin at 2 g every 4 h, and her oral prednisone dosage was reduced gradually from 100 mg daily to 20 mg daily over the following week.The patient's symptoms continued to progress, however, with erythema spreading from the dorsum of the left wrist to the elbow. At 4 weeks after the exploratory surgery, the patient was admitted to Stanford University Medical Center. Oxacillin was discontinued, and intravenous vancomycin, given as 1 g every 12 h, was initiated. The following day, surgical exploration and debridement of the left wrist and forearm were performed, and necrosis involving multiple extensor tendons of the wrist was noted intraoperatively. Specimens from her wrist joint and tendons were sent for bacterial, mycobacterial, and fungal cultures. Small, gray colonies of a mold grew in a culture derived from an extensor tendon. Early examination of this mold revealed thin, septate hyphae branching at acute angles. On the basis of this morphology, intravenous voriconazole was initiated at a loading dose of 6 mg/kg every 12 h for two doses, followed by 4 mg/kg given every 12 h; prednisone was continued at 20 mg daily. Two days later, diminished pain and erythema of the patient's forearm and elbow were noted. The mold was ultimately identified as Scedosporium apiospermum. The patient showed continued improvement over a 10-day course of intravenous voriconazole...

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Skin infection caused by Scedosporium apiospermum

Cited by 17 publications

References 16 publications

Scedosporium apiospermum: changing clinical spectrum of a therapy-refractory opportunist*

Scedosporium apiospermum: changing clinical spectrum of a therapy-refractory opportunist*

Fungal Infections Complicating Lung Transplantation

Scedosporium apiospermumSoft Tissue Infection Successfully Treated with Voriconazole: Potential Pitfalls in the Transition from Intravenous to Oral Therapy

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