Skin depigmentation due to antimalarial prophylaxis with chloroquine

Selvaag, Edgar

doi:10.1016/s0035-9203(96)90436-8

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Pigment Changes and Drug Reactions

Das

Kourosh

2015

Cutaneous Drug Eruptions

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Medications have long been known to cause pigmentary changes of the skin. While this frequently occurs as post-infl ammatory changes of a resolving drug-induced rash, medications can also directly promote dyspigmentation through stimulation of melanin production and/or deposition of drug (or drug metabolite) within the skin. Medications can also cause hypo-or depigmentation. Drug-induced pigmentary changes depend on factors such as the particular drug (or heavy metal) and level of deposition or melanocyte stimulation (or inhibition of melanogenesis). Drug-induced dyschromias have historically been categorized in a medication-class based manner. Because the clinician is generally faced with a patient whose chief complaint is dyspigmentation (which comes in varying shades), we propose a color-based approach for understanding druginduced dyschromias.

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