Skin changes secondary to hydroxyurea therapy

Kennedy, B. J.

doi:10.1001/archderm.111.2.183

Cited by 62 publications

(38 citation statements)

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“…The list of adverse effects of hydroxyurea includes marrow suppression, skin ulcers, eruption and alopecia, renal function impairment, pulmonary edema and neurological reactions [2, 3, 4]. There are only few reports about its involvement in drug fever [5, 6, 7, 8, 9, 10].…”

Section: Introductionmentioning

confidence: 99%

Hydroxyurea as a Cause of Drug Fever

Braester¹,

Quitt

2000

Acta Haematol

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We report on a patient with essential thrombocythemia treated with hydroxyurea who became febrile 3 weeks after the treatment was started. After drug withdrawal, the fever resolved but after rechallenge there was recurrence of the fever. Although hydroxyurea-induced fever is rare, this drug must be added to the list of drugs that produce fever and the physicians should be aware of this possibility.

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Section: Introductionmentioning

confidence: 99%

Hydroxyurea as a Cause of Drug Fever

Braester¹,

Quitt

2000

Acta Haematol

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“…HU can cause an array of skin lesions, such as a lichenoid eruption on the dorsum of hands and feet (referred to as HU dermopathy) [15], dermatomyositis-like skin changes [16, 17], partial alopecia, increased pigmentation, scaling, atrophy of the skin and subcutaneous tissue, nail changes and erythema of the face and hands [18]. Leg ulcers are a relatively frequent side effect of HU [12, 13, 14, 19, 20, 21, 22, 23].…”

Section: Discussionmentioning

confidence: 99%

Leg Ulcers in Patients with Myeloproliferative Disorders: Disease- or Treatment-Related?

Bader

Banyai²,

Boni³

et al. 2000

Dermatology

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Leg ulcers are a relatively frequent problem in patients with myeloproliferative disorders under treatment with hydroxyurea (HU). The pathogenesis is currently unknown and may be multifactorial. Concomitant arterial or venous disease may play a contributing role in the development of these wounds. Vasculitis, cryoglobulinemia and pyoderma gangrenosum should be considered if typical clinical signs are present. We report on 3 patients with myeloproliferative disorders who developed HU-induced leg ulcers and review the literature. HU-induced leg ulcers share clinical features which can help to differentiate them from leg ulcers of other etiologies: occurrence under long-term treatment with HU at a dose of at least 1 g/day, localization in the malleolar region and spontaneous healing when HU is discontinued. We conclude that differentiation between disease-related and treatment-induced leg ulcers can be difficult and may not always be possible. In HU-induced leg ulcers, cessation of the drug typically leads to wound healing.

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“…An sonnenexponierten Hautstellen [4] und selten an der Mundschleimhaut [7, 10] können spinozelluläre Karzinome entstehen. Zudem wurden palmoplantare Keratodermien, multiple Keratosen im Gesicht und das Auftreten von Alopezie beschrieben [17].…”

Section: Diskussionunclassified

Ulzerationen unter Therapie mit Hydroxyharnstoff

Boneberger

Rupec

Ruzicka³

2009

Hautarzt

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Hydroxyurea is frequently used for therapy of myeloproliferative disorders. One cutaneous side-effect is painful, therapy-resistant ulcers which have bizarre configurations and occur at atypical sites for venous ulcers. Improvement or healing often first occurs when hydroxyurea is discontinued. We report on one patient with essential thrombocythemia and two with polycythemia vera, who developed such ulcers during hydroxyurea therapy. In one case, the ulcers developed shortly after hydroxyurea was started. In addition we give a short overview of the current literature.

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Skin changes secondary to hydroxyurea therapy

Cited by 62 publications

References 0 publications

Hydroxyurea as a Cause of Drug Fever

Hydroxyurea as a Cause of Drug Fever

Leg Ulcers in Patients with Myeloproliferative Disorders: Disease- or Treatment-Related?

Ulzerationen unter Therapie mit Hydroxyharnstoff

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