Skin cancer treatment by albumin/5-Fu loaded magnetic nanocomposite spheres in a mouse model

Misak, Heath Edward; Zacharias, Nora M.; Shi, Zheng; Hwang, Shyh‐Lung; Man, Ka-Poh; Asmatulu, Ramazan; Yang, Shang-You

doi:10.1016/j.jbiotec.2013.01.003

Cited by 50 publications

(19 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However SCC is a common disease also, with a prevalence of more than 700,000 cases each year in the United States [93]. …”

Section: Drug Delivery Nanoparticles In Nonmelanoma Skin Cancers: mentioning

confidence: 99%

“…This can be obtained through curettage and desiccation, surgical excision, radiation therapy, cryosurgery, Mohs micrographic surgery, and micrographic surgery [93]. …”

Section: Drug Delivery Nanoparticles In Nonmelanoma Skin Cancers: mentioning

confidence: 99%

“…Although skin cancer is not the most mortal form of cancers, it is the most common form of malignancy in the United States and many other countries [8]. Melanoma represents only a very small proportion of skin cancer incidence, but it accounts for the vast majority of skin cancer deaths.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Drug Delivery Nanoparticles in Skin Cancers

Dianzani

Zara

Maina

et al. 2014

BioMed Research International

139

111

View full text Add to dashboard Cite

Nanotechnology involves the engineering of functional systems at nanoscale, thus being attractive for disciplines ranging from materials science to biomedicine. One of the most active research areas of the nanotechnology is nanomedicine, which applies nanotechnology to highly specific medical interventions for prevention, diagnosis, and treatment of diseases, including cancer disease. Over the past two decades, the rapid developments in nanotechnology have allowed the incorporation of multiple therapeutic, sensing, and targeting agents into nanoparticles, for detection, prevention, and treatment of cancer diseases. Nanoparticles offer many advantages as drug carrier systems since they can improve the solubility of poorly water-soluble drugs, modify pharmacokinetics, increase drug half-life by reducing immunogenicity, improve bioavailability, and diminish drug metabolism. They can also enable a tunable release of therapeutic compounds and the simultaneous delivery of two or more drugs for combination therapy. In this review, we discuss the recent advances in the use of different types of nanoparticles for systemic and topical drug delivery in the treatment of skin cancer. In particular, the progress in the treatment with nanocarriers of basal cell carcinoma, squamous cell carcinoma, and melanoma has been reported.

show abstract

“…However SCC is a common disease also, with a prevalence of more than 700,000 cases each year in the United States [93]. …”

Section: Drug Delivery Nanoparticles In Nonmelanoma Skin Cancers: mentioning

confidence: 99%

“…This can be obtained through curettage and desiccation, surgical excision, radiation therapy, cryosurgery, Mohs micrographic surgery, and micrographic surgery [93]. …”

Section: Drug Delivery Nanoparticles In Nonmelanoma Skin Cancers: mentioning

confidence: 99%

See 1 more Smart Citation

Drug Delivery Nanoparticles in Skin Cancers

Dianzani

Zara

Maina

et al. 2014

BioMed Research International

139

111

View full text Add to dashboard Cite

show abstract

“…The interaction between the polyelectrolytes and the antibacterial drugs used could be a reason for the weaker antibacterial function of the polyelectrolyte-coated samples loaded with combination drugs. From a different experiment, it was clearly shown that the incorporation of chitosan into gentamicin-loaded bone cement for use in joint replacement surgery had no antimicrobial benefit [21][22][23][24][25][26]. Here, the best result is with the UV-treated and gentamicin-loaded samples.…”

Section: Samples Without Antibacterial Treatmentmentioning

confidence: 96%

Antibacterial polyelectrolyte-coated Mg alloys for biomedical applications

et al. 2014

Self Cite

View full text Add to dashboard Cite

This study deals with two biomedical subjects: corrosion rates of polyelectrolyte-coated magnesium (Mg) alloys, mainly used for biomedical purposes, and antibacterial properties of these alloys. Thin sheets of Mg alloys were coated with cationic polyelectrolyte chitosan (CHI) and anionic polyelectrolyte carboxymethyl cellulose (CMC) using a layer-by-layer coating method and then embedded with antibacterial agents under vacuum. Electrochemical impedance spectroscopy was employed to analyze these samples in order to detect their corrosion properties at different conditions. In the electrochemical analysis section, a corrosion rate of 72 mille inches per year was found in a salt solution for the sample coated with a 12 phosphonic acid self-assembled monolayer and 9 CHI/CMC multilayers. In the antibacterial tests, gentamicin was used to investigate the effects of the drug embedded with the coated surfaces against the Escherichia coli (E. coli) bacteria. Antibacterial studies were tested using the disk diffusion method. Based on the standard diameter of the zone of inhibition chart, the antibacterial diffusion from the surface strongly inhibited bacterial growth in the regions. The largest recorded diameter of the zone of inhibition was 50 mm for the pre-UV treated and gentamicin-loaded sample, which is more than three times the standard diameter.

show abstract

“…Skin cancer is the most common form of malignancy, although it is not the deadliest [87]. The most common forms of skin cancer are basal cell carcinoma (~2.8 million U.S. cases annually [88]), and squamous cell carcinoma (~700,000 U.S. cases annually [89]).…”

Section: Topical Applications Of Nanoparticlesmentioning

confidence: 99%

Nanoparticles and nanofibers for topical drug delivery

Goyal

Macri

Kaplan

et al. 2016

Journal of Controlled Release

443

227

View full text Add to dashboard Cite

This review provides the first comprehensive overview of the use of both nanoparticles and nanofibers for topical drug delivery. Researchers have explored the use of nanotechnology, specifically nanoparticles and nanofibers, as drug delivery systems for topical and transdermal applications. This approach employs increased drug concentration in the carrier, in order to increase drug flux into and through the skin. Both nanoparticles and nanofibers can be used to deliver hydrophobic and hydrophilic drugs and are capable of controlled release for a prolonged period of time. The examples presented provide significant evidence that this area of research has—and will continue to have — a profound impact on both clinical outcomes and the development of new products.

show abstract

Skin cancer treatment by albumin/5-Fu loaded magnetic nanocomposite spheres in a mouse model

Cited by 50 publications

References 19 publications

Drug Delivery Nanoparticles in Skin Cancers

Drug Delivery Nanoparticles in Skin Cancers

Antibacterial polyelectrolyte-coated Mg alloys for biomedical applications

Nanoparticles and nanofibers for topical drug delivery

Contact Info

Product

Resources

About