Skin and soft tissue infections and bacteremia caused by Vibrio cincinnatiensis

Kunitomo, Kotaro; Uemura, Naomichi; Shimizu, Taro; Hayano, Satoshi; Tsuji, Takeshi

doi:10.1016/j.idcr.2022.e01564

Cited by 4 publications

(4 citation statements)

References 11 publications

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“…In addition to V. anuillarum, a variety of other Vibrio spp., namely, V. alginolyticus, V. campbellii, V. cincinnatiensis, V. coralliilyticus, V. uvialis, V. furnissii, V. hollisae, V. metschnikovii, V. mediterranei, V. mimicus, V. navarrensis, V. ordalii, V. proteolyticus, and V. splendidus are potential opportunistic pathogens in humans [36][37][38][39][40][41][42][43][44]. Up to 10% of vibriosis cases reported each year originate from the non-agglutinating vibrios that were recognized as non-pathogenic species [45].…”

Section: Discussionmentioning

confidence: 99%

Homologous relationship between FabG involved in fatty acid biosynthesis and SDR on chromosome II in the multi-chromosome pathogen Vibrio anguillarum

Kim,

Park,

Rafquzzaman

et al. 2024

Preprint

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Vibrio anguillarum threatens fish and larval farming industries and human health worldwide. The fatty acids of cell membrane phospholipids are crucial to bacterial response to diverse environments and survival. Previously, short-chain dehydrogenase/reductase (SDR) was identified on chromosome II of the multichromosomal V. anguillarum. A comparison of SDR and the enzyme FabG-1b (encoded on chromosome I and responsible for the β-ketoacyl acyl carrier protein (ACP) reductase in fatty acid biosynthesis (FAS II)) showed that the amino acid sequence homology was only 33.2%; however, the core of functionality, which includes the NAD(P)-binding domain and the conserved region of the active site, the topologies predicted using sequence-based homology modeling, and the quaternary homotetramer-type structures showed a significant similarity. FabG-1b was specific to the substrates fluorinated and halogenated aliphatic ketones, aromatic ketones, and aromatic β-ketoesters and SDR toward non-fluorinated and non-halogenated aliphatic ketones, aromatic ketones, and non-aromatic β-ketoesters. This complementary catalytic efficiencies of the two enzymes on various substrates conclusively supports the hypothesis that the two enzymes are likely homologs. This is the first study to report potential paralogous enzymes FabG-1b and SDR in Vibrio. This information improves our understanding of bacterial FAS for establishing strategies to overcome infectious diseases caused by pathogenic strains and identify targets for developing new antibacterial agents.

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Section: Discussionmentioning

confidence: 99%

Homologous relationship between FabG involved in fatty acid biosynthesis and SDR on chromosome II in the multi-chromosome pathogen Vibrio anguillarum

Kim,

Park,

Rafquzzaman

et al. 2024

Preprint

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“…Mupapillomavirus 2 and Dolosigranulum pigrum were classified as irrelevant pathogens ( 51 , 52 ). Vibrio cincinnatiensis and Wickerhamomyces anomalus are rarely pathogenic, but it was also reported that they can cause infections ( 53 – 56 ), and W. anomalus was also detected by culture. Associated with the clinical manifestations in the patients, these two pathogens were classified as causative pathogens.…”

Section: Discussionmentioning

confidence: 99%

Metagenomic Next-Generation Sequencing for the Diagnosis of Neonatal Infectious Diseases

et al. 2022

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To the best of our knowledge, this is the first report on evaluating the performance of mNGS using cfDNA and RNA from body fluid and blood samples for diagnosing neonatal infections. mNGS of RNA and cfDNA can achieve the unbiased detection and identification of trace pathogens from different kinds of neonatal body fluid and blood samples with a high total coincidence rate (226/331; 68.3%) against final clinical diagnoses by sample. The best timing for mNGS detection in neonatal infections ranged from 1 to 3 days, rather than 0 days, after the start of continuous antimicrobial therapy.

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“…Currently, the genus Vibrio consists of 137 identified species ( www.bacterio.net/vibrio.html [accessed 26 September 2022]); among them, Vibrio cincinnatiensis is one of the 12 Vibrio species that are considered potential human pathogens ( 1 ). To date, three cases of V. cincinnatiensis infections have been reported in humans ( 2 – 4 ). However, because of the diversity of disease presentation of V. cincinnatiensis , including septicemia and meningitis, enteritis, and skin and soft tissue infections in immunocompromised and immunocompetent elderly patients with no history of marine exposure, knowledge of the prevalence of this rare organism in environmental settings is essential ( 2 – 4 ).…”

Section: Lettermentioning

confidence: 99%

“…To date, three cases of V. cincinnatiensis infections have been reported in humans ( 2 – 4 ). However, because of the diversity of disease presentation of V. cincinnatiensis , including septicemia and meningitis, enteritis, and skin and soft tissue infections in immunocompromised and immunocompetent elderly patients with no history of marine exposure, knowledge of the prevalence of this rare organism in environmental settings is essential ( 2 – 4 ).…”

Section: Lettermentioning

confidence: 99%