Skin and bones

Non-traumatic myositis ossificans circumscripta at elbow joint in a 9-year old child

“…The mechanism of non-traumatic MOC is unclear so far. Studies 5 have shown that myositis ossificans has a huge connection with bone morphogenetic protein (BMP) expression which in serum in children may be higher than adults. This point may explain why using cefazolin, etimicin and non-steroidal anti-inflammatory drugs are ineffective.…”

Progressive osseous heteroplasia in the face of a child

“…Fewer than 40 cases are known. However, underdiagnosis is likely [Kaplan, 1996]. To our knowledge, this is the second case affecting the face [see also Yeh et al, 2000].…”

Progressive osseous heteroplasia

“…11 In the absence of markers or biological clues, the genetic approach remains the most likely way to progress. An entire genome search is hampered by the rarity of large pedigrees.…”