1997
DOI: 10.1001/archderm.133.12.1539
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Skin abnormalities in neurofibromatosis 2

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Cited by 16 publications
(19 citation statements)
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“…Nodular subcutaneous schwannomas are identified in 43–48% of patients and often cause pain and are sensitive to pressure. 3,19 Neurofibromas, by contrast, are rarely identified in neurofibromatosis type 2 and are distinguished from schwannomas histologically by their loose and haphazard arrangement of Schwann cells and fibroblasts within a collagen–myxoid matrix. Symptomatic lesions of peripheral nerves are mainly treated by surgical resection.…”
Section: Neurological Manifestationsmentioning
confidence: 99%
See 1 more Smart Citation
“…Nodular subcutaneous schwannomas are identified in 43–48% of patients and often cause pain and are sensitive to pressure. 3,19 Neurofibromas, by contrast, are rarely identified in neurofibromatosis type 2 and are distinguished from schwannomas histologically by their loose and haphazard arrangement of Schwann cells and fibroblasts within a collagen–myxoid matrix. Symptomatic lesions of peripheral nerves are mainly treated by surgical resection.…”
Section: Neurological Manifestationsmentioning
confidence: 99%
“…3,4,19 They have a raised frequency in severely affected patients and are often multiple (mean skin tumours; 7·1). 3,4,19 No predilection to site has been substantiated. Most skin tumours are schwannomas, although histologically confirmed neurofibromas or mixed tumours have been occasionally identified.…”
Section: Cutaneous Manifestationsmentioning
confidence: 99%
“…Therefore, it is important to obtain as many tumors as possible to increase the probability of finding LOH. Skin tumors, which are present in approximately half of NF2 patients, 4 may serve as a tumor source for such testing because they can be removed easily. 21 Presymptomatic/prenatal diagnosis based on tumor analysis can also be applied for other tumor suppressor gene syndromes, such as retinoblastomas, 22 tuberous sclerosis, 23 von Hippel-Lindau disease, 24 and neurofibromatosis 1 (NF1).…”
Section: Discussionmentioning
confidence: 99%
“…Although bilateral vestibular schwannomas are the hallmark of this autosomal dominant disorder, [1][2][3] other cerebral tumors (e.g., meningiomas), cutaneous tumors, 4 and ophthalmologic abnormalities 5 are also common. NF2 is caused by mutations in the NF2 tumor suppressor gene on the long arm of chromosome 22.…”
mentioning
confidence: 99%
“…In these tumours there is an admixture of cell types (Schwann cells, fibroblasts, and mast cells) and the tumour usually has identifiable axons within it. Neurofibromas mainly occur in the skin 25 (where they are still outnumbered by schwannomas by a factor of 5-10), but also on the spinal nerve roots. 40 Halliday et al 40 showed that, in a series of spinal schwannomas and neurofibromas, all spinal tumours in patients with NF1 were neurofibromas while, with one exception, all spinal tumours in patients with NF2 were schwannomas (one patient had a mixed tumour).…”
Section: Pathologymentioning
confidence: 99%