1998
DOI: 10.1007/s002130050541
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Abstract: The purpose of this study was to determine the influence of the D1-selective partial agonist SKF 38393 on the odor detection performance of rats using high precision olfactometry and a go/no-go operant task. Previous studies have found that the D2 receptor partial agonist quinpirole decreases such performance, but the influences of D1 receptor activation are unknown. In experiment 1, such detection performance to the odorant ethyl acetate was enhanced by SKF 38393, relative to saline, in male rats at 7.5 and 1… Show more

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Cited by 30 publications
(20 citation statements)
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“…When rats were administered the dopamine D 2 receptor agonist quinpirole, for example, rat odor detection performance decreased; this effect was eliminated when pre- or post-treated with the D 2 antagonist spiperone, further illustrating the specificity of the effect [11]. In contrast, the administration of the D 1 -selective partial agonist SKF 38393 enhanced odor detection performance, whereas the D 1 receptor antagonist SCH 23390 eliminated this effect [10]. Similarly, activation of D 1 receptors or blockade of D 2 receptors each have been shown to improve the ability of adult rats to discriminate structurally and perceptually similar odorant pairs, whereas D 1 blockade or D 2 activation impair odor discrimination [39].…”
Section: Discussionmentioning
confidence: 99%
“…When rats were administered the dopamine D 2 receptor agonist quinpirole, for example, rat odor detection performance decreased; this effect was eliminated when pre- or post-treated with the D 2 antagonist spiperone, further illustrating the specificity of the effect [11]. In contrast, the administration of the D 1 -selective partial agonist SKF 38393 enhanced odor detection performance, whereas the D 1 receptor antagonist SCH 23390 eliminated this effect [10]. Similarly, activation of D 1 receptors or blockade of D 2 receptors each have been shown to improve the ability of adult rats to discriminate structurally and perceptually similar odorant pairs, whereas D 1 blockade or D 2 activation impair odor discrimination [39].…”
Section: Discussionmentioning
confidence: 99%
“…Thus, intraperitoneal administration of the dopamine D1 selective partial agonist SKF 38393 enhances the odor detection performance of rats (Doty et al, 1998), whereas the dopamine D2 agonist quinpirole depresses such performance (Doty and Risser, 1989). Similar effects are observed when the task is to discriminate subtle differences between two odorants (Yue et al, 2004).…”
Section: Etiology Of Pd-related Olfactory Dysfunctionmentioning
confidence: 99%
“…The drug solutions were administered in volumes of 1.5 ml/kg. The doses of SKF 38393 and ketanserin used for systemic administration were chosen based on previous literature (Doty et al 1998;Kalkman et al 1998). In experiment 3, 15 rats received intra-mPFC infusions of saline or ketanserin in two subsequent tests.…”
Section: Drug Administration and Experimental Designmentioning
confidence: 99%