Skeletal-related events and mortality among older men with advanced prostate cancer

Onukwugha, Eberechukwu; Yong, Candice; Mullins, C. Daniel; Seal, Brian; McNally, Diane; Hussain, Arif

doi:10.1016/j.jgo.2014.03.002

Cited by 25 publications

(16 citation statements)

References 20 publications

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“…Moreover, among patients diagnosed with bone metastases, 40% to 50% will experience at least 1 skeletal‐related event (SRE), which is defined as a pathologic fracture, spinal cord compression, or the need for radiation or surgery to the bone. Compared with nonmetastatic PC, bone metastases are associated with a 2‐ to 7‐fold increase in the risk of death, and the risk is even higher among patients with bone metastases and at least 1 SRE …”

Section: Introductionmentioning

confidence: 99%

Impact of subsequent metastases on costs and medical resource use for prostate cancer patients initially diagnosed with localized disease

Shore

Mehra

et al. 2017

Cancer

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Section: Introductionmentioning

confidence: 99%

Impact of subsequent metastases on costs and medical resource use for prostate cancer patients initially diagnosed with localized disease

Shore

Mehra

et al. 2017

Cancer

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“…Prostate cancer is the second leading cause of cancer‐related death in American men and many PCa patients develop skeletal metastasis . Insufficient vitamin D intake and deficiency and insufficiency in serum could be prevalent among men at risk of prostate cancer .…”

Section: Introductionmentioning

confidence: 99%

Vitamin D₃ potentiates the growth inhibitory effects of metformin in DU145 human prostate cancer cells mediated by AMPK/mTOR signalling pathway

Gao

Liang

et al. 2015

Clin Exp Pharma Physio

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SUMMARYMetformin and vitamin D 3 both exhibit a strong antiproliferative action in numerous cancer cell lines, including in human prostate cancer cells. Here we showed that the combination of the two drugs had a much stronger effect on DU145 human prostate cancer cell growth than either drug alone. In this research, cell proliferation was measured by methylthiazol tetrazolium (MTT) assay. Cell apoptosis was determined with Hoechst 33342 staining. Western blotting and cell cycle analyses were used to elucidate potential mechanisms of interaction between the drugs. It is shown that in cultured DU145 cells, vitamin D 3 combined with metformin exhibits synergistic effects on cell proliferation and apoptosis. The underlying antitumor mechanisms may involve altered cycle distribution with a G1/S cell cycle arrest, activation of phospho-AMPK with subsequent inhibition of downstream mTOR signalling pathway, down-regulate c-Myc expression, and reducing the level of anti-apoptotic protein p-Bcl-2. In conclusion, metformin and vitamin D 3 synergistically inhibit DU145 cell growth, indicating a promising clinical therapeutic strategy for the treatment of androgen-independent prostate cancer.

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“…(4-6) Additionally, fractures are associated with severe bone pain, limited mobility, and hospitalization for treatment, as well as negatively associated with overall survival independent of pathological stage. (4, 7, 8) In addition to (lower) bone density, factors associated with an increased risk of fracture include: older age, multiple coexisting conditions, history of falls and previous fractures, lower body mass index, poor functional status, and lifestyle factors (such as physical inactivity, smoking and alcohol use).…”

Section: Introductionmentioning

confidence: 99%

Development and validation of a prognostic index for fracture risk in older men undergoing prostate cancer treatment

Graham-Steed

Soulos

Dearing

et al. 2014

Journal of Geriatric Oncology

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Objectives Men treated with androgen deprivation therapy (ADT) or radiation therapy (RT) for prostate cancer have an increased risk for fractures. Given uncertainty as to whether specific clinical factors can identify men at increased risk, we sought to develop a prognostic index for risk of fracture in this population. Materials and methods We used the Surveillance, Epidemiology, and End Results-Medicare database to identify men who received ADT or RT after being diagnosed with localized prostate cancer in 2007-2009. Cox proportional hazards models tested the association of potential risk factors with fracture. In a derivation group, hazard ratios were used to assign points for factors independently related to fracture. The prognostic index was then applied to a validation group. Results The sample of 5,824 men had a median age of 73.0 years; 82.9% were white and 8.6% had a fracture within 2 years of treatment for prostate cancer. The Cox model identified 8 variables (age, race, hormone treatment, Elixhauser score, anxiety, Parkinson's, fall-inducing medications and disability status) independently associated with fracture. In the derivation cohort, 4.3% of the sample experienced a fracture in the low-risk group, 8.9% in the intermediate group, and 19.2% in the high-risk group (C statistic, 0.749). The index was applied to the validation cohort (C statistic, 0.782). Conclusion The prognostic index can help to identify patients at increased risk for fracture. This underscores the importance of identifying risk factors for fracture, given the substantial variation in fracture risk in men treated with ADT or RT.

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Skeletal-related events and mortality among older men with advanced prostate cancer

Cited by 25 publications

References 20 publications

Impact of subsequent metastases on costs and medical resource use for prostate cancer patients initially diagnosed with localized disease

Impact of subsequent metastases on costs and medical resource use for prostate cancer patients initially diagnosed with localized disease

Vitamin D₃ potentiates the growth inhibitory effects of metformin in DU145 human prostate cancer cells mediated by AMPK/mTOR signalling pathway

Development and validation of a prognostic index for fracture risk in older men undergoing prostate cancer treatment

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Skeletal-related events and mortality among older men with advanced prostate cancer

Cited by 25 publications

References 20 publications

Impact of subsequent metastases on costs and medical resource use for prostate cancer patients initially diagnosed with localized disease

Impact of subsequent metastases on costs and medical resource use for prostate cancer patients initially diagnosed with localized disease

Vitamin D3 potentiates the growth inhibitory effects of metformin in DU145 human prostate cancer cells mediated by AMPK/mTOR signalling pathway

Development and validation of a prognostic index for fracture risk in older men undergoing prostate cancer treatment

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Vitamin D₃ potentiates the growth inhibitory effects of metformin in DU145 human prostate cancer cells mediated by AMPK/mTOR signalling pathway