Skeletal muscle quantitative nuclear magnetic resonance imaging and spectroscopy as an outcome measure for clinical trials (part II)

Carlier, P.; Marty, Benjamin; Scheidegger, O.; Sousa, Paulo Loureiro de; Baudin, P.-Y.; Snezhko, Eduard; Vlodavets, D.

doi:10.17650/2222-8721-2017-7-1-11-29

Cited by 8 publications

(15 citation statements)

References 197 publications

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“…Robust T 2w mapping, which is comparable to MRS as a reference standard, is essential to get an insight into the spatial distribution of acute and chronic alterations and disease activity in the muscle tissue of patients with NMD. 3,12 A robust and fat independent determination of the important biomarker T 2w is essential, especially in NMD patients, as regions with healthy muscle tissue, edematous muscle tissue, and fatty infiltrated muscle tissue are often simultaneously present in a single muscle of NMD patients.…”

Section: Discussionmentioning

confidence: 99%

“…1,2 Muscle T 2w , in contrast to muscle global T 2 , reflects the chemically selective T 2 decay of the water component in the muscle tissue and is therefore considered an indicator for water mobility in the tissue. 2,3 Water mobility in the muscle tissue is affected by several circumstances, such as inflammation, myocyte swelling, sarcoplasmic leakiness, cell necrosis, hydrostatic edema, denervation, or exercise of moderate to high intensity. 1,2 Therefore, T 2w is a rather unspecific parameter, although responding rapidly to alterations in the muscle tissue and allowing assessment of acute as well as chronic changes.…”

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confidence: 99%

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Water T₂ Mapping in Fatty Infiltrated Thigh Muscles of Patients With Neuromuscular Diseases Using a T₂‐Prepared 3D Turbo Spin Echo With SPAIR

Schlaeger

Weidlich

Klupp

et al. 2019

Magnetic Resonance Imaging

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Background: Muscle water T 2 (T 2w ) has been proposed as a biomarker to monitor disease activity and therapy effectiveness in patients with neuromuscular diseases (NMD). Multi-echo spin-echo (MESE) is known to be affected by fatty infiltration. A T 2 -prepared 3D turbo spin echo (TSE) is an alternative method for T 2 mapping, but has been only applied in healthy muscles. Purpose: To examine the performance of T 2 -prepared 3D TSE in combination with spectral adiabatic inversion recovery (SPAIR) in measuring T 2w in fatty infiltrated muscles based on simulations and in vivo measurements in thigh muscles of patients with NMD. Study Type: Prospective. Subjects: One healthy volunteer, 34 NMD patients. Field Strength/Sequence: T 2 -prepared stimulated echo acquisition mode (STEAM) magnetic resonance spectroscopy (MRS), SPAIR STEAM MRS, and SPAIR T 2 -prepared STEAM MRS were performed in the subcutaneous fat of a healthy volunteer's thigh. T 2 mapping based on SPAIR 2D MESE and SPAIR T 2 -prepared 3D TSE was performed in the NMD patients' thigh region. Multi-TE STEAM MRS was performed for measuring a reference T 2w at different thigh locations. Assessment: The behavior of the fat spectrum in the SPAIR T 2 -prepared 3D TSE was simulated using Bloch simulations. The in vivo T 2 results of the imaging methods were compared to the in vivo T 2w MRS results. Statistical Tests: Pearson correlation coefficient with slope and intercept, relative error. Results: The simulated T 2 for the SPAIR T 2 -prepared 3D TSE sequence remained constant within a relative error of not more than 4% up to a fat fraction of 80%. In vivo T 2 values of SPAIR T 2 -prepared 3D TSE were in good agreement with the T 2w values of STEAM MRS (R = 0.86; slope = 1.12; intercept = -1.41 ms). In vivo T 2 values of SPAIR 2D MESE showed large deviations from the T 2w values of STEAM MRS (R = 0.14; slope = 0.32; intercept = 38.83 ms). Data Conclusion: The proposed SPAIR T 2 -prepared 3D TSE shows reduced sensitivity to fatty infiltration for T 2w mapping in the thigh muscles of NMD patients.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Water T₂ Mapping in Fatty Infiltrated Thigh Muscles of Patients With Neuromuscular Diseases Using a T₂‐Prepared 3D Turbo Spin Echo With SPAIR

Schlaeger

Weidlich

Klupp

et al. 2019

Magnetic Resonance Imaging

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“…In addition, both the relaxation and contraction states should also be taken into consideration when analyzing muscle injuries because the characteristics of muscle fibers under load are different from relaxation state [12,13]. In our study, biceps brachii was the main motor of upper limb skeletal muscle movement.…”

Section: Discussionmentioning

confidence: 94%

Quantitative Analysis of Textural Features Extracted from Sonograms of Biceps under Different Physiological States

Jia¹,

Zhao²,

Xu³

et al. 2020

Advanced Ultrasound in Diagnosis and Therapy

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To quantitatively analyze the difference of texture features of skeletal muscle in high-frequency ultrasound images under different physiological states using the multiscale decomposition method of ultrasound echo intensity interface reflections. Methods:High frequency ultrasound images of the biceps brachii in different physiological states were collected from 20 healthy volunteers. In offline state, eight texture parameters including mean of texture gray scale (Mean), standard variance (SDev) of gray scale, number of blobs (NOB) of texture density, irregularity (IRGL) of texture primitive shape, mean size of blobs (SOB) of texture primitive, homogeneity of distribution (HOD) of texture uniformity, directionality of texture distribution (DOD), and periodicity of texture distribution (POD) were extracted by MATLAB software and compared and analyzed statistically.Results: With the use of high frequency ultrasound, all healthy volunteers' biceps brachii showed isoechoic muscle bundles, organized arrangement of muscle fibers, and distinct and intact texture of structure. In different physiological states of biceps brachii of the same gender group, the NOB and the Mean showed statistically differences (P < 0.05). In the relaxation state of biceps brachii between different gender groups, the average SOB and the DOD showed statistically differences (P < 0.05). In the load state of biceps brachii between different genders, the NOB and the Mean showed statistically differences (P < 0.05). Conclusions:The ultrasonic image changes of muscle fibers under different physiological states can be identified by quantitative texture characteristic parameters, providing more information for clinical computer-aided diagnosis of skeletal muscle injury.

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“…10,11 Another quantitative MRI biomarker is the water T 2 (T 2,H2O ) relaxation time, which is sensitive to changes in tissue water compartmentation, free-to-bound water ratio, and pH alterations. 1,12 An increase in T 2,H2O can be due to a range of different causes such as interstitial or cellular edema, inflammation, or necrosis, which can reflect disease activity mechanisms that precede fat replacement of skeletal muscle in neuromuscular diseases such as Duchenne muscular dystrophy (DMD). 1,7 Its sensitivity to pathophysiological changes and to the use of treatments such as corticosteroids could render T 2,H2O an interesting MRI biomarker and surrogate outcome measure in clinical studies.…”

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confidence: 99%

“…1,12 An increase in T 2,H2O can be due to a range of different causes such as interstitial or cellular edema, inflammation, or necrosis, which can reflect disease activity mechanisms that precede fat replacement of skeletal muscle in neuromuscular diseases such as Duchenne muscular dystrophy (DMD). 1,7 Its sensitivity to pathophysiological changes and to the use of treatments such as corticosteroids could render T 2,H2O an interesting MRI biomarker and surrogate outcome measure in clinical studies. 13 Elevated T 2,H2O values have been observed in muscle diseases with a known inflammatory component, such as inclusion body myositis (IBM) 2,6 and dermtomyositis, 14 in dystrophic disorders such as DMD 7,13 and facioscapulohumeral dystrophy, 14 and in myopathies where inflammation is generally absent, such as late-onset Pompe disease 4 and GNE (GNE is the gene encoding for the enzyme UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase) myopathy.…”

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confidence: 99%

New Insights into the Spread of MRS‐Based Water T2 Values Observed in Highly Fatty Replaced Muscles

Reyngoudt

Baudin

Carlier

et al. 2023

Magnetic Resonance Imaging

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BackgroundThe reference standard for assessing water T2 (T2,H2O) at high fat fraction (FF) is 1H MRS. T2,H2O (T2,H2O,MRS) dependence on FF (FFMRS) has recently been demonstrated in muscle at high FF (i.e. ≥60%).PurposeTo investigate the relationship between T2,H2O,MRS and FFMRS in the thigh/leg muscles of patients with neuromuscular diseases and to compare with quantitative MRI.Study TypeRetrospective case–control study.PopulationA total of 151 patients with neuromuscular disorders (mean age ± standard deviation = 52.5 ± 22.6 years, 54% male), 44 healthy volunteers (26.5 ± 13.0 years, 57% male).Field Strength/SequenceA 3‐T; single‐voxel stimulated echo acquisition mode (STEAM) MRS, multispin echo (MSE) imaging (for T2 mapping, T2,H2O,MRI), three‐point Dixon imaging (for FFMRI and mapping).AssessmentMono‐exponential and bi‐exponential models were fitted to water T2 decay curves to extract T2,H2O,MRS and FFMRS. Water resonance full‐width‐at‐half‐maximum (FWHM) and B0 spread (∆B0) values were calculated. T2,H2O,MRI (mean), FFMRI (mean, kurtosis, and skewness), and (mean) values were estimated in the MRS voxel.Statistical TestsMann–Whitney U tests, Kruskal–Wallis tests. A P‐value <0.05 was considered statistically significant.ResultsNormal T2,H2O,MRS threshold was defined as the 90th percentile in healthy controls: 30.3 msec. T2,H2O,MRS was significantly higher in all patients with FFMRS < 60% compared to healthy controls. We discovered two subgroups in patients with FFMRS ≥ 60%: one with T2,H2O,MRS ≥ 30.3 msec and one with T2,H2O,MRS < 30.3 msec including abnormally low T2,H2O,MRS. The latter subgroup had significantly higher water resonance FWHM, ∆B0, FFMRI kurtosis, and skewness values but nonsignificantly different (P = 1.00) and long T2,H2O,MRS component and its fraction (P > 0.11) based on the bi‐exponential analysis.Data ConclusionThe findings suggest that the cause for (abnormally) T2,H2O,MRS at high FFMRS is biophysical, due to differences in susceptibility between muscle and fat (increased FWHM and ∆B0), rather than pathophysiological such as compartmentation changes, which would be reflected by the bi‐exponential analysis.Evidence Level3Technical EfficacyStage 3

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Skeletal muscle quantitative nuclear magnetic resonance imaging and spectroscopy as an outcome measure for clinical trials (part II)

Cited by 8 publications

References 197 publications

Water T₂ Mapping in Fatty Infiltrated Thigh Muscles of Patients With Neuromuscular Diseases Using a T₂‐Prepared 3D Turbo Spin Echo With SPAIR

Water T₂ Mapping in Fatty Infiltrated Thigh Muscles of Patients With Neuromuscular Diseases Using a T₂‐Prepared 3D Turbo Spin Echo With SPAIR

Quantitative Analysis of Textural Features Extracted from Sonograms of Biceps under Different Physiological States

New Insights into the Spread of MRS‐Based Water T2 Values Observed in Highly Fatty Replaced Muscles

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Skeletal muscle quantitative nuclear magnetic resonance imaging and spectroscopy as an outcome measure for clinical trials (part II)

Cited by 8 publications

References 197 publications

Water T2 Mapping in Fatty Infiltrated Thigh Muscles of Patients With Neuromuscular Diseases Using a T2‐Prepared 3D Turbo Spin Echo With SPAIR

Water T2 Mapping in Fatty Infiltrated Thigh Muscles of Patients With Neuromuscular Diseases Using a T2‐Prepared 3D Turbo Spin Echo With SPAIR

Quantitative Analysis of Textural Features Extracted from Sonograms of Biceps under Different Physiological States

New Insights into the Spread of MRS‐Based Water T2 Values Observed in Highly Fatty Replaced Muscles

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Water T₂ Mapping in Fatty Infiltrated Thigh Muscles of Patients With Neuromuscular Diseases Using a T₂‐Prepared 3D Turbo Spin Echo With SPAIR

Water T₂ Mapping in Fatty Infiltrated Thigh Muscles of Patients With Neuromuscular Diseases Using a T₂‐Prepared 3D Turbo Spin Echo With SPAIR