Skeletal muscle–melanocyte association during tadpole tail resorption in a tropical frog, Clinotarsus curtipes Jerdon (Anura, Ranoidea)

Divya, Lekha; Beyo, Reston S.; Sreejith, P; Akbarsha, Mohammad Abdulkader; Oommen, Oommen V.

doi:10.1016/j.zool.2009.11.002

Cited by 10 publications

(4 citation statements)

References 38 publications

(32 reference statements)

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“…It had been suggested that their melanin-containing granules decrease oxidative stress by contributing to neutralization of reactive oxygen species (Zuasti et al, 1989). Melanomacrophages also play a key role in the process of tail resorption in tadpoles during metamorphosis (Divya et al, 2010). The presence of melanomacrophages in the goldfish heart during repair and regeneration suggests an important role in injury response and cardiac remodeling in this species.…”

Section: Discussionmentioning

confidence: 99%

Cardiac repair and regenerative potential in the goldfish (Carassius auratus) heart

Grivas

Haag

Johnson

et al. 2014

Comparative Biochemistry and Physiology Part C: Toxicology &

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The remarkable ability of the heart to regenerate has been demonstrated in the zebrafish and giant danio, two fish members of the cyprinid family. Here we use light and electron microscopy to examine the repair response in the heart of another cyprinid, the goldfish (Carassius auretus), following cautery injury to a small portion of its ventricular myocardium. We observed a robust inflammatory response in the first two weeks consisting primarily of infiltrating macrophages, heterophils, and melanomacrophages. These inflammatory cells were identified in the lumen of the spongy heart, within the site of the wound, and attached to endocardial cells adjacent to the site of injury. Marked accumulation of collagen fibers and increased connective tissue were also observed during the first and second week in a transition zone between healthy and injured myocardium as well as in adjacent sub-epicardial regions. The accumulation of collagen and connective tissue however did not persist. The presence of capillaries was also noted in the injured area during repair. The replacement of the cauterized region of the ventricle by myocardial tissue was achieved by 6 weeks. The presence of ethynyl deoxyuridine-positive cardiac myocytes and partially differentiated cardiac myocytes during repair suggest effective cardiac myocyte driven regeneration mechanisms also operate in the injured goldfish heart, and are similar to those observed in zebrafish and giant danio. Our data suggest the ability for cardiac regeneration may be widely conserved among cyprinids.

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Section: Discussionmentioning

confidence: 99%

Cardiac repair and regenerative potential in the goldfish (Carassius auratus) heart

Grivas

Haag

Johnson

et al. 2014

Comparative Biochemistry and Physiology Part C: Toxicology &

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“…Presumably, they cause degradation of apoptotic epidermal cells which later on results in an empty space. Divya et al (2010) proposed that the long processes of melanocytes pervade the skeletal muscle fibers concomitant with or preceding the breakdown of muscle fibers into sarcolytes and subsequently cause muscle disintegration by delivering melanin. They suggest a lysosome-like role of melanocytes in the fragmentation of muscle into sarcolytes.…”

Section: Discussionmentioning

confidence: 99%

“…Macrophages remove the cell debris resulting out of muscle and epidermal degradation (Kinoshita et al, 1985;Nishikawa et al, 1998) whereas fibroblasts contribute in the removal of collagenous components of tail like the notochord and the basement membrane (Berry et al, 1998). Recently, Divya et al (2010) associated melanocytes in muscle degradation. They suggest that degradation of muscle bundles into sarcolytes is mediated by melanocytes and this attracts the macrophages which later on engulf the spent melanocytes and the sarcolytes.…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical localization of cathepsin D and a possible role of melanocytes during tail resorption in tadpoles of a tropical toad

Mahapatra

2012

Journal of Morphology

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Programmed cell death during anuran tail resorption is primarily brought about by apoptosis. Cathepsin D, a lysosomal aspartyl protease, is involved in the death of tail tissues. Thus, anuran tail resorption presents an ideal model to study cathepsin-mediated cell death during vertebrate development. Present study describes the trend of specific activity of cathepsin D in the tail of different developmental stages and immunohistochemical localization of cathepsin D in the tail tissues of the common Asian toad, Duttaphrynus melanostictus. Cathepsin D was involved in programmed cell death in epidermis, muscle, spinal cord, and blood cells in the resorbing tail. Interestingly, it was also involved in the pre-resorbing tail before visible tail resorption which indicates initiation of cell death even before actually the tail resorbs. Melanocytes were found to be one of the causative agents in degrading tail tissues and were associated with the degradation of muscle, epidermis and spinal cord of the resorbing tail.

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“…It has recently turned out that melanophores play an important part in amphibian metamorphosis, which includes total re-building of the tissues, including skin. An interesting manifestation of this process is deposition of mel-anin in the liver and other visceral organs of the animals (Divya et al, 2010). Understanding the origin and mechanism of splenic melanization in mice is, therefore, important from the point of view of general biology, evolution of the skin, and experimental dermatology (Rakers et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Splenic melanosis during normal murine C57BL/6 hair cycle and after chemotherapy.

et al. 2013

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Cancer chemotherapy is associated with serious side effects, including temporary hair loss and impairment of pigmentation. We suspect that ectopic melanin deposition occurring due to chemotherapy may add to these effects worsening the already unpleasant symptoms. We associated the ectopic occurrence of follicular melanin after chemotherapy with splenic melanosis - an interesting example of extradermal melanin localization - and we expected an increase in splenic melanin deposition after chemotherapy. Using the C57BL/6 murine model of synchronized hair cycle induced by depilation, we visualized splenic melanin by means of several histological and histochemical protocols of staining: hematoxylin and eosin, May-Grünwald-Giemsa and Fontana-Masson. Unexpectedly, the splenic deposition of melanin decreased due to application of cyclophosphamide (i.p. 120 mg/ kg body weight on day 9 post depilation). The drop was abrupt and lasted for at least 5 days (day 13-18 post depilation), as compared with normal hair cycle. Moreover, in mice with normal, depilation-induced hair cycle we observed a similar drop shortly before entering catagen (day 15 post depilation), followed by a slow and partial increase in splenic melanization up to day 27 post depilation in both groups. We conclude that cyclophosphamide negatively affects splenic melanization and/or extradermal transfer of ectopic melanin from the dystrophic hair follicles, but the most powerful down-regulator of splenic melanosis is normal and dystrophic catagen - the phase of hair follicle involution and re-modelling.

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Skeletal muscle–melanocyte association during tadpole tail resorption in a tropical frog, Clinotarsus curtipes Jerdon (Anura, Ranoidea)

Cited by 10 publications

References 38 publications

Cardiac repair and regenerative potential in the goldfish (Carassius auratus) heart

Cardiac repair and regenerative potential in the goldfish (Carassius auratus) heart

Immunohistochemical localization of cathepsin D and a possible role of melanocytes during tail resorption in tadpoles of a tropical toad

Splenic melanosis during normal murine C57BL/6 hair cycle and after chemotherapy.

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