Size distribution and clinicoradiological signs of aggressiveness in odontogenic myxoma—three-dimensional analysis and systematic review

Abstract

Locularity and volumetric size characterization might help in therapeutic decision-making and could help to improve our understanding of OM.

Image segmentation-based volume approximation—volume as a factor in the clinical management of osteolytic jaw lesions

“…The maximum tumour diameter has shown to be error-prone and imprecise when wanting to decide between conservative and aggressive treatment approaches. 5 The present investigation strongly suggests the association between the maximum tumour diameter and the real intraosseous extent (volume) is inconsistent and thus relative over-or even underestimation can be the result. Prospective investigations would be desirable to, e.g.…”

“…The three most commonly surgically treated odontogenic tumours are ameloblastoma, the keratocystic odontogenic tumour and OM. 5,7,23 For diagnostics and therapeutic planning, a method that reliably delineates the extent of an osteolytic jaw lesions and simultaneously allows for the relative visualization of surrounding healthy tissue is indispensable for guidance of the managing craniomaxillofacial surgeon. This is of utmost importance in the context of pre-surgical planning of osseous reconstructive procedures.…”

“…Hence, we considered patients who have been diagnosed with either one of the two most common odontogenic cysts (periapical and dentigerous) or with one of the three most common potentially infiltrative odontogenic tumours [ameloblastoma, keratocystic odontogenic tumour, odontogenic myxoma (OM)] by histopathological, radiological and clinical means. 4,5,7,15 Each individual received pre-operative diagnostics according to a standardized imaging protocol as well as therapeutic assessment between 2007 and 2017. Due to the retrospective nature of this study, it was granted an exemption in writing by the University Hospital IRB.…”

“…10 Multiple consecutive studies confirmed these results. [4][5][6][7][16][17][18][19][20] Maximum tumour diameter and formula-based volume approximation With the help of ITK-SNAP, we manually measured the three maximum orthogonal tumour diameters in centimeters (cm) in anteroposterior, mediolateral and craniocaudal direction. The measurement was automatically indicated by the program in millimeters.…”

“…The size is frequently taken as a surrogate for the aggressiveness and respectively the growth potential of a lesion, thereby constituting an imaging biomarker. [4][5][6][7] Importantly, in the context of pharmaceutically targeted therapy of neoplasms in general, radiological size delineation is important in order to quantify the therapeutic success as judged by neoplastic disease regression. Pharmaceutically targeted therapy of ameloblastomas, the most prevalent neoplastic odontogenic tumour, with BRAF-inhibitors has made it to clinical trials.…”