Size- and defect-controlled anti-oxidant enzyme mimetic and radical scavenging properties of cerium oxide nanoparticles

Vinothkumar, G.; Arunkumar, P.; Mahesh, Arun; Dhayalan, Arunkumar; Babu, K. Suresh

doi:10.1039/c8nj04435j

Cited by 51 publications

(53 citation statements)

References 61 publications

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“…Here, the catalytic activity of these antioxidants is implicated in the concentration of oxygen vacancies or the proportion of different valence states. [ 236,237 ] For example, a higher number of oxygen vacancies (Ce 3+ /Ce 4+ ) in ceria are required in the elimination of • O 2 − and • OH. [ 238 ] Therefore, the effect of the proportion of different valence states on antioxidant performance should be evaluated.…”

Section: Principles For the Design Of Ros‐associated Nanomedicinesmentioning

confidence: 99%

Reactive Oxygen Species‐Regulating Strategies Based on Nanomaterials for Disease Treatment

et al. 2020

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Reactive oxygen species (ROS) play an essential role in physiological and pathological processes. Studies on the regulation of ROS for disease treatments have caused wide concern, mainly involving the topics in ROS‐regulating therapy such as antioxidant therapy triggered by ROS scavengers and ROS‐induced toxic therapy mediated by ROS‐elevation agents. Benefiting from the remarkable advances of nanotechnology, a large number of nanomaterials with the ROS‐regulating ability are developed to seek new and effective ROS‐related nanotherapeutic modalities or nanomedicines. Although considerable achievements have been made in ROS‐based nanomedicines for disease treatments, some fundamental but key questions such as the rational design principle for ROS‐related nanomaterials are held in low regard. Here, the design principle can serve as the initial framework for scientists and technicians to design and optimize the ROS‐regulating nanomedicines, thereby minimizing the gap of nanomedicines for biomedical application during the design stage. Herein, an overview of the current progress of ROS‐associated nanomedicines in disease treatments is summarized. And then, by particularly addressing these known strategies in ROS‐associated therapy, several fundamental and key principles for the design of ROS‐associated nanomedicines are presented. Finally, future perspectives are also discussed in depth for the development of ROS‐associated nanomedicines.

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Section: Principles For the Design Of Ros‐associated Nanomedicinesmentioning

confidence: 99%

Reactive Oxygen Species‐Regulating Strategies Based on Nanomaterials for Disease Treatment

et al. 2020

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“…Cerium nitrate hexahydrate (oxidizer) and nanoceria (precursor) reacted with glycine (fuel) under various conditions in ammonium nitrate that produced 6-30 nm nanoceria. 41,42 2(g) . The aqueous solution containing redox mixture in glassware then was heated to 150 C, e.g., aer boiling, foams undergoes combustion with a ame to produce ceria.…”

Section: Combustion Methodsmentioning

confidence: 99%

Synthesis and characterization of nanoceria for electrochemical sensing applications

et al. 2021

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“…On the contrary, nanoparticles have the competency to scavenge the free radicals, and they can play an important role in preventing various diseases linked with the free radicals attack on cells and biological targets 57,58 . In this context, various nanoparticles, such as silica nanoparticles, iron-oxide nanoparticles, cerium oxide nanoparticles, metal nanoparticles, and organic (i.e., melanin, lignin) nanoparticles have been designed and assessed for their potential free radical scavenging capacity (RSC) 18,30,[59][60][61][62] . Here, we have investigated the in vitro RSC of different Au and Ag nanoparticles employing ABTS assay.…”

Section: Resultsmentioning

confidence: 99%

Engineering bioactive surfaces on nanoparticles and their biological interactions

Matur¹,

Madhyastha

Shruthi³

et al. 2020

Sci Rep

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The successful integration of nanoparticles into biomedical applications requires modulation of their surface properties so that the interaction with biological systems is regulated to minimize toxicity for biological function. In the present work, we have engineered bioactive surfaces on gold (Au) and silver (Ag) nanoparticles and subsequently evaluated their interaction with mouse skin fibroblasts and macrophages. The Au and Ag nanoparticles were synthesized using tyrosine, tryptophan, isonicotinylhydrazide, epigallocatechin gallate, and curcumin as reducing and stabilizing agents. The nanoparticles thus prepared showed surface corona and exhibited free radical scavenging and enzyme activities with limited cytotoxicity and genotoxicity. We have thus developed avenues for engineering the surface of nanoparticles for biological applications.

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Size- and defect-controlled anti-oxidant enzyme mimetic and radical scavenging properties of cerium oxide nanoparticles

Abstract: Improved enzymatic activity and concentration-dependent selective activation of peroxidase and oxidase activity of combustion-synthesized nanoceria.

Cited by 51 publications

References 61 publications

Reactive Oxygen Species‐Regulating Strategies Based on Nanomaterials for Disease Treatment

Reactive Oxygen Species‐Regulating Strategies Based on Nanomaterials for Disease Treatment

Synthesis and characterization of nanoceria for electrochemical sensing applications

Engineering bioactive surfaces on nanoparticles and their biological interactions

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