Sixty-Day Mortality Among 520 Italian Hospitalized COVID-19 Patients According to the Adopted Ventilatory Strategy in the Context of an Integrated Multidisciplinary Clinical Organization: A Population-Based Cohort Study

Potalivo, Antonella; Montomoli, Jonathan; Facondini, Francesca; Sanson, Gianfranco; Agli, Luigi Arcangelo Lazzari; Perin, Tiziana; Cristini, Francesco; Cortesi, Enrico; Giovanni, R. De; Biagetti, Carlo; Panzini, Ilaria; Ravaioli, Cinzia; Bitondo, Maria Maddalena; Guerra, Daniela; Giuliani, Giovanni; Mosconi, Elena; Guarino, Sonia; Marchionni, Elisa; Gangitano, Gianfilippo; Valentini, Ilaria; Giampaolo, Luca Di; Muratore, Francesco

doi:10.2147/clep.s278709

Cited by 16 publications

(14 citation statements)

References 24 publications

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“…However, even studies comprising patients with moderate-to-severe respiratory failure (as judged by baseline PaO 2 /FiO 2 ratio, SpO 2 /FiO 2 ratio, or ROX index) found that many patients survived with NIRS alone, and this survival could often be predicted by a positive response to a trial of NIRS over several hours. 14 , 18 , 19 , 21 , 27 , 34 , 39 , 41 , 44 , 46 , 48 , 53 , 54 , 55 , 56 , 59 , 65 , 66 , 72 , 74 , 75 , 77 , 79 , 93 , 94 …”

Section: Discussionmentioning

confidence: 99%

“…Search terms yielded 84 articles relating to a total of 13 140 patients after exclusion of duplicates, and after screening titles, abstracts, and full text for relevance specifically to outcomes with the use of NIRS in patients with COVID-19 ( appendix p 1 ). 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 ,…”

Section: Studies Of Nirs In Covid-19mentioning

confidence: 99%

“…Other than two multicentre RCTs from Italy and the UK, 38 , 95 22 prospective and 61 retrospective observational studies were identified, reporting a median of 71 patients (IQR 40–127) per study. 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 ,…”

Section: Studies Of Nirs In Covid-19mentioning

confidence: 99%

“…The median duration of NIRS, where reported, is shown in tables 1–3. 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , …”

Section: Studies Of Nirs In Covid-19unclassified

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Non-invasive respiratory support in the management of acute COVID-19 pneumonia: considerations for clinical practice and priorities for research

Weerakkody

Arina

Glenister

et al. 2022

The Lancet Respiratory Medicine

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Section: Discussionmentioning

confidence: 99%

Section: Studies Of Nirs In Covid-19mentioning

confidence: 99%

Section: Studies Of Nirs In Covid-19mentioning

confidence: 99%

Section: Studies Of Nirs In Covid-19unclassified

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Non-invasive respiratory support in the management of acute COVID-19 pneumonia: considerations for clinical practice and priorities for research

Weerakkody

Arina

Glenister

et al. 2022

The Lancet Respiratory Medicine

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“…For the comparison of NIV versus IMV, there are now a total of 13 studies, of which 6 were added since our last update ( 3 , 5 , 6 , 8 , 11 , 14 ). A total of 4 studies in this living systematic review provided adjusted effect estimates for mortality ( 11 , 14–16 ), with a pooled hazard ratio of 0.74 (95% CI, 0.46 to 1.18), but in the presence of high, unexplained heterogeneity (very low certainty of evidence) ( Supplement Table 3 and Supplement Figure 2 ).…”

mentioning

confidence: 99%

Update Alert 3: Ventilation Techniques and Risk for Transmission of Coronavirus Disease, Including COVID-19

et al. 2022

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Phase‐Resolved Functional Lung (PREFUL) MRI May Reveal Distinct Pulmonary Perfusion Defects in Postacute COVID‐19 Syndrome: Sex, Hospitalization, and Dyspnea Heterogeneity

Ouyang,

Tang,

Klimes

et al. 2024

Magnetic Resonance Imaging

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BackgroundPulmonary perfusion defects have been observed in patients with coronavirus disease 2019 (COVID‐19). Currently, there is a need for further data on non‐contrast‐enhanced MRI in COVID patients. The early identification of heterogeneity in pulmonary perfusion defects among COVID‐19 patients is beneficial for their timely clinical intervention and management.PurposeTo investigate the utility of phase‐resolved functional lung (PREFUL) MRI in detecting pulmonary perfusion disturbances in individuals with postacute COVID‐19 syndrome (PACS).Study TypeProspective.SubjectsForty‐four participants (19 females, mean age 64.1 years) with PACS and 44 healthy subjects (19 females, mean age 59.5 years). Moreover, among the 44 patients, there were 19 inpatients and 25 outpatients; 19 were female and 25 were male; 18 with non‐dyspnea and 26 with dyspnea.Field Strength/Sequence3‐T, two‐dimensional (2D) spoiled gradient‐echo sequence.AssessmentVentilation and perfusion‐weighted maps were extracted from five coronal slices using PREFUL analysis. Subsequently, perfusion defect percentage (QDP), ventilation defect percentage (VDP), and ventilation‐perfusion match healthy (VQM) were calculated based on segmented lung parenchyma ventilation and perfusion‐weighted maps. Additionally, clinical features, including demographic data (such as sex and age) and serum biomarkers (such as D‐dimer levels), were evaluated.Statistical TestsSpearman correlation coefficients to explore relationships between clinical features and QDP, VDP, and VQM. Propensity score matching analysis to reduce the confounding bias between patients with PACS and healthy controls. The Mann–Whitney U tests and Chi‐squared tests to detect differences between groups. Multivariable linear regression analyses to identify factors related to QDP, VDP, and VQM. A P‐value <0.05 was considered statistically significant.ResultsQDP significantly exceeded that of healthy controls in individuals with PACS (39.8% ± 15.0% vs. 11.0% ± 4.9%) and was significantly higher in inpatients than in outpatients (46.8% ± 17.0% vs. 34.5% ± 10.8%). Moreover, males exhibited pulmonary perfusion defects significantly more frequently than females (43.9% ± 16.8% vs. 34.4% ± 10.2%), and dyspneic participants displayed significantly higher perfusion defects than non‐dyspneic patients (44.8% ± 15.8% vs. 32.6% ± 10.3%). QDP showed a significant positive relationship with age (β = 0.50) and D‐dimer level (β = 0.72).Data ConclusionPREFUL MRI may show pulmonary perfusion defects in patients with PACS. Furthermore, perfusion impairments may be more pronounced in males, inpatients, and dyspneic patients.Evidence Level2Technical EfficacyStage 2

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Sixty-Day Mortality Among 520 Italian Hospitalized COVID-19 Patients According to the Adopted Ventilatory Strategy in the Context of an Integrated Multidisciplinary Clinical Organization: A Population-Based Cohort Study

Cited by 16 publications

References 24 publications

Non-invasive respiratory support in the management of acute COVID-19 pneumonia: considerations for clinical practice and priorities for research

Non-invasive respiratory support in the management of acute COVID-19 pneumonia: considerations for clinical practice and priorities for research

Update Alert 3: Ventilation Techniques and Risk for Transmission of Coronavirus Disease, Including COVID-19

Phase‐Resolved Functional Lung (PREFUL) MRI May Reveal Distinct Pulmonary Perfusion Defects in Postacute COVID‐19 Syndrome: Sex, Hospitalization, and Dyspnea Heterogeneity

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