2020
DOI: 10.31219/osf.io/vbp86
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Shahan Mamoor

Abstract: Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes to discover genes associated with brain metastasis in patients with metastatic breast cancer. We found that SIX homeobox 1, encoded by SIX1, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to normal breast tissues. SIX1 mRNA was present at incre…

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