2010
DOI: 10.1371/journal.ppat.1000764
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Abstract: We have used multiplexed high-throughput sequencing to characterize changes in small RNA populations that occur during viral infection in animal cells. Small RNA-based mechanisms such as RNA interference (RNAi) have been shown in plant and invertebrate systems to play a key role in host responses to viral infection. Although homologs of the key RNAi effector pathways are present in mammalian cells, and can launch an RNAi-mediated degradation of experimentally targeted mRNAs, any role for such responses in mamm… Show more

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Cited by 236 publications
(273 citation statements)
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References 116 publications
(166 reference statements)
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“…Some studies have reported that RNAi can impact antiviral immunity in mammals during influenza A virus, hepatitis C virus, Nodamura virus and, more recently, human enterovirus 71 infection (Wang et al , 2006; Matskevich & Moelling, 2007; Li et al , 2013, 2016; Maillard et al , 2013; Qiu et al , 2017). In contrast, others have found low abundance of viRNAs in mammalian somatic cells infected with various viruses, and only a modest effect of Dicer deficiency on viral replication, suggesting that RNAi is not an active mechanism of antiviral defence in most mammalian cell types (Parameswaran et al , 2010; Girardi et al , 2013; Backes et al , 2014; Bogerd et al , 2014; Schuster et al , 2017). RNAi may be particularly important in undifferentiated mammalian cells, and clear evidence of the existence of endogenous RNAi, dsRNA‐mediated RNAi (dsRNAi), or antiviral RNAi has been documented in oocytes, embryonic teratocarcinoma cell lines and mouse embryonic stem cells (mESCs), respectively (Billy et al , 2001; Flemr et al , 2013; Maillard et al , 2013).…”
Section: Introductionmentioning
confidence: 98%
See 1 more Smart Citation
“…Some studies have reported that RNAi can impact antiviral immunity in mammals during influenza A virus, hepatitis C virus, Nodamura virus and, more recently, human enterovirus 71 infection (Wang et al , 2006; Matskevich & Moelling, 2007; Li et al , 2013, 2016; Maillard et al , 2013; Qiu et al , 2017). In contrast, others have found low abundance of viRNAs in mammalian somatic cells infected with various viruses, and only a modest effect of Dicer deficiency on viral replication, suggesting that RNAi is not an active mechanism of antiviral defence in most mammalian cell types (Parameswaran et al , 2010; Girardi et al , 2013; Backes et al , 2014; Bogerd et al , 2014; Schuster et al , 2017). RNAi may be particularly important in undifferentiated mammalian cells, and clear evidence of the existence of endogenous RNAi, dsRNA‐mediated RNAi (dsRNAi), or antiviral RNAi has been documented in oocytes, embryonic teratocarcinoma cell lines and mouse embryonic stem cells (mESCs), respectively (Billy et al , 2001; Flemr et al , 2013; Maillard et al , 2013).…”
Section: Introductionmentioning
confidence: 98%
“…However, Dicer's catalytic function appears mainly confined to precursor microRNA (pre‐miRNA) processing, and its antiviral capacity in mammals remains much debated (Parameswaran et al , 2010; Cullen et al , 2013; Li et al , 2013, 2016; Maillard et al , 2013; Backes et al , 2014; Ding & Voinnet, 2014; Kennedy et al , 2015; Jeffrey et al , 2017; tenOever, 2017). Some studies have reported that RNAi can impact antiviral immunity in mammals during influenza A virus, hepatitis C virus, Nodamura virus and, more recently, human enterovirus 71 infection (Wang et al , 2006; Matskevich & Moelling, 2007; Li et al , 2013, 2016; Maillard et al , 2013; Qiu et al , 2017).…”
Section: Introductionmentioning
confidence: 99%
“…Whether RNAi also acts as an antiviral mechanism in mammals is hotly debated (Parameswaran et al , 2010; Cullen et al , 2013; Li et al , 2013; Maillard et al , 2013; Backes et al , 2014; Ding & Voinnet, 2014; Kennedy et al , 2015). Infection of mammalian somatic cells with various viruses results in little accumulation of viRNA (Parameswaran et al , 2010; Girardi et al , 2013; Backes et al , 2014; Bogerd et al , 2014) and, where tested, virus replication is only modestly affected in Dicer‐defective cells (Wang et al , 2006b; Matskevich & Moelling, 2007; Bogerd et al , 2014).…”
Section: Introductionmentioning
confidence: 99%
“…They are present in various amounts in a large number of viruses and they impact cellular functions. 11,66,67 Many described proteins and RNAs acting as RSSs have mostly been shown to increase viral replication in cell lines from different origin than the natural host, although some have been shown in natural host cells. 68 In addition, the induction of RISC proteins upon virus entry has not been shown, pointing to an intrinsic mechanism rather than an inducible pathway.…”
Section: Discussionmentioning
confidence: 99%