Six-minute walk test and factors affecting exercise capacity in children with cystic fibrosis

Abstract

PURPOSE: This study aimed to compare the result of the six-minute walk test (6MWT) in patients with cystic fibrosis (CF) aged < 20 years old and individuals without CF. METHODS: In this cross-sectional study, 50 children and adolescents with CF and 20 children and adolescents without CF underwent the 6MWT. Vital signs before and immediately after the 6MWT and six-minute walk distance (6MWD) were evaluated. RESULTS: The mean change in heart rate, percentage of peripheral oxygen saturation (SpO2%), systolic blood pressure, respiratory rate, and dyspnea severity during the 6MWT was significantly higher in patients with CF. In the case group, 6MWD was associated with regular chest physical therapy (CPT) and forced expiratory volume (FEV)> 80% . Patients with CF receiving regular CPT or mechanical vibration and with FEV in the first second > 80% showed better physical capacity during the 6MWT (smaller Sp02% decline and lower dyspnea perception). CONCLUSION: Children and adolescents with CF have lower physical capacity compared to individuals without CF. CPT and mechanical vibration could be used to increase physical capacity in this population.

Clinimetric properties of field exercise tests in cystic fibrosis: a systematic review

“…69 studies investigated the validity of the 6MWT by comparing the test to CPET [ 19 , 77 , 86 , 92 ], the 3MST [ 61 , 63 , 66 ], the ISWT [ 25 ], the 1STS [ 80 , 81 ] and other clinical outcomes for pwCF [ 19 , 20 , 25 , 63 , 77 , 81 , 85 , 87 , 88 , 90 , 92 – 140 ] ( tables 11 and S38 ).…”

“…On the whole, relationships were stronger between 6MWW and CPET measurements compared to 6MWD ( table 11 ). Criterion validity has been extensively investigated for the 6MWT (55 studies) with variable relationships to clinical outcomes, including physical activity (r=−0.11–0.0.827) [ 77 , 97 , 121 , 134 , 138 ], muscle strength (r=0.13–0.73) [ 25 , 77 , 88 , 109 , 113 , 138 , 139 ] and spirometry (r=−0.43–0.76) [ 19 , 20 , 25 , 77 , 80 , 85 , 87 , 88 , 90 , 97 , 102 , 105 , 109 , 110 , 112 , 123 , 125 , 131 , 133 , 138 , 140 ] ( table S38 ). Predictive validity of 6MWD was reported in five studies, with those who have a poorer 6MWD having lower rates of survival and more days in hospital ( table S42 ) [ 20 , 28 , 101 , 116 , 137 ].…”

Clinimetric properties of field exercise tests in cystic fibrosis: a systematic review

“…69 studies investigated the validity of the 6MWT by comparing the test to CPET [ 19 , 77 , 86 , 92 ], the 3MST [ 61 , 63 , 66 ], the ISWT [ 25 ], the 1STS [ 80 , 81 ] and other clinical outcomes for pwCF [ 19 , 20 , 25 , 63 , 77 , 81 , 85 , 87 , 88 , 90 , 92 – 140 ] ( tables 11 and S38 ).…”

“…On the whole, relationships were stronger between 6MWW and CPET measurements compared to 6MWD ( table 11 ). Criterion validity has been extensively investigated for the 6MWT (55 studies) with variable relationships to clinical outcomes, including physical activity (r=−0.11–0.0.827) [ 77 , 97 , 121 , 134 , 138 ], muscle strength (r=0.13–0.73) [ 25 , 77 , 88 , 109 , 113 , 138 , 139 ] and spirometry (r=−0.43–0.76) [ 19 , 20 , 25 , 77 , 80 , 85 , 87 , 88 , 90 , 97 , 102 , 105 , 109 , 110 , 112 , 123 , 125 , 131 , 133 , 138 , 140 ] ( table S38 ). Predictive validity of 6MWD was reported in five studies, with those who have a poorer 6MWD having lower rates of survival and more days in hospital ( table S42 ) [ 20 , 28 , 101 , 116 , 137 ].…”

Clinimetric properties of field exercise tests in cystic fibrosis: a systematic review

“…69 studies investigated the validity of the 6MWT by comparing the test to CPET [ 19 , 77 , 86 , 92 ], the 3MST [ 61 , 63 , 66 ], the ISWT [ 25 ], the 1STS [ 80 , 81 ] and other clinical outcomes for pwCF [ 19 , 20 , 25 , 63 , 77 , 81 , 85 , 87 , 88 , 90 , 92 – 140 ] ( tables 11 and S38 ).…”

“…On the whole, relationships were stronger between 6MWW and CPET measurements compared to 6MWD ( table 11 ). Criterion validity has been extensively investigated for the 6MWT (55 studies) with variable relationships to clinical outcomes, including physical activity (r=−0.11–0.0.827) [ 77 , 97 , 121 , 134 , 138 ], muscle strength (r=0.13–0.73) [ 25 , 77 , 88 , 109 , 113 , 138 , 139 ] and spirometry (r=−0.43–0.76) [ 19 , 20 , 25 , 77 , 80 , 85 , 87 , 88 , 90 , 97 , 102 , 105 , 109 , 110 , 112 , 123 , 125 , 131 , 133 , 138 , 140 ] ( table S38 ). Predictive validity of 6MWD was reported in five studies, with those who have a poorer 6MWD having lower rates of survival and more days in hospital ( table S42 ) [ 20 , 28 , 101 , 116 , 137 ].…”

Clinimetric properties of field exercise tests in cystic fibrosis: a systematic review

“…69 studies investigated the validity of the 6MWT by comparing the test to CPET [ 19 , 77 , 86 , 92 ], the 3MST [ 61 , 63 , 66 ], the ISWT [ 25 ], the 1STS [ 80 , 81 ] and other clinical outcomes for pwCF [ 19 , 20 , 25 , 63 , 77 , 81 , 85 , 87 , 88 , 90 , 92 – 140 ] ( tables 11 and S38 ).…”

“…On the whole, relationships were stronger between 6MWW and CPET measurements compared to 6MWD ( table 11 ). Criterion validity has been extensively investigated for the 6MWT (55 studies) with variable relationships to clinical outcomes, including physical activity (r=−0.11–0.0.827) [ 77 , 97 , 121 , 134 , 138 ], muscle strength (r=0.13–0.73) [ 25 , 77 , 88 , 109 , 113 , 138 , 139 ] and spirometry (r=−0.43–0.76) [ 19 , 20 , 25 , 77 , 80 , 85 , 87 , 88 , 90 , 97 , 102 , 105 , 109 , 110 , 112 , 123 , 125 , 131 , 133 , 138 , 140 ] ( table S38 ). Predictive validity of 6MWD was reported in five studies, with those who have a poorer 6MWD having lower rates of survival and more days in hospital ( table S42 ) [ 20 , 28 , 101 , 116 , 137 ].…”