Site of action of methotrexate in psoriasis

Differences in the Biochemical Activity in Hairless Mouse Skin and Other Organs after Systemic and Topical Methotrexate Treatment

“…Delayed suppression appeared 48 hrs after application. In other studies on psoriasis, intradermal methotrexate injection suppressed epidermal mitosis (18,19), but failed to improve psoriasis (8,11). We found no report that methotrexate is effective in psoriasis after intradermal injection.…”

Clinical, dermoscopic, and histopathologic evaluation of topical methotrexate 1% hydrogel versus topical Calcipotriol 0.005% cream in the treatment of plaque psoriasis

“…The poor results of using topical MTX reported by previous reports in the late fifties and sixties of the past centuries 16,17 may be related to the differences in the basic formula used (cream) and methods of applications.…”

Topically applied methotrexate is rapidly delivered into skin by fractional laser ablation

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