Sister chromatid exchange induced by ‘pan masala’ (a betel quid ingredient) in male mice in vivo

Long-term carcinogenicity of pan masala in Swiss mice

“…In other studies, pan masala per se was reported to exhibit genotoxic and mutagenic properties in several short-term assays (Adhvaryu et al, 1989;Bagwe et al, 1990;Mukherjee and Giri, 1991;Polasa et al, 1993). Chronic feeding of pan masala was shown to impair liver function in rats and to affect the mouse germinal cells by inducing sperm-head abnormalities Sarma et al, 1992).…”

“…Habitual use of areca nut is causally associated with increased risk of human oral pre-cancer and cancer (Chin and Lee, 1970; IARC, 1985;Sinor et al, 1990). Catechu, another constituent of pan masala, was found to possess strong mutagenic (Stich et al, 1983) and clastogenic (Giri et al, 1987) activity, while lime is known to cause irritation and hyperplasia of the oral mucosa (Dunham et al, 1966).In other studies, pan masala per se was reported to exhibit genotoxic and mutagenic properties in several short-term assays (Adhvaryu et al, 1989;Bagwe et al, 1990;Mukherjee and Giri, 1991;Polasa et al, 1993). Chronic feeding of pan masala was shown to impair liver function in rats and to affect the mouse germinal cells by inducing sperm-head abnormalities Sarma et al, 1992).…”

Long-term carcinogenicity of pan masala in Swiss mice

“…In other studies, pan masala per se was reported to exhibit genotoxic and mutagenic properties in several short-term assays (Adhvaryu et al, 1989;Bagwe et al, 1990;Mukherjee and Giri, 1991;Polasa et al, 1993). Chronic feeding of pan masala was shown to impair liver function in rats and to affect the mouse germinal cells by inducing sperm-head abnormalities Sarma et al, 1992).…”

“…Habitual use of areca nut is causally associated with increased risk of human oral pre-cancer and cancer (Chin and Lee, 1970; IARC, 1985;Sinor et al, 1990). Catechu, another constituent of pan masala, was found to possess strong mutagenic (Stich et al, 1983) and clastogenic (Giri et al, 1987) activity, while lime is known to cause irritation and hyperplasia of the oral mucosa (Dunham et al, 1966).In other studies, pan masala per se was reported to exhibit genotoxic and mutagenic properties in several short-term assays (Adhvaryu et al, 1989;Bagwe et al, 1990;Mukherjee and Giri, 1991;Polasa et al, 1993). Chronic feeding of pan masala was shown to impair liver function in rats and to affect the mouse germinal cells by inducing sperm-head abnormalities Sarma et al, 1992).…”

Areca-nut extract modulates antigen-specific immunity and augments inflammation in ovalbumin-sensitized mice

“……”

Evaluation of carcinogenic/co-carcinogenic activity of a common chewing product, pan masala, in mouse skin, stomach and esophagus

“…Other histopathological observations revealed fatty and dysplastic changes, and hemangioma in the liver in the experimental groups. Bagwe et al, 1990;Mukherjee and Giri, 1991). Increased cytogenetic damage has been reported in peripheral-blood lymphocytes and exfoliated buccal mucosa of pan-masala consumers (Dave et al, 1991).…”

“…In keeping with the genotoxic properties of the individual constituents, an extract of pan masala was found to increase the frequencies of sister chromatid exchanges and chromosomal aberrations in mouse bone-marrow cells (Mukherjee and Giri, 1991) and Chinese hamster ovary cells (Adhvaryu et al, 1989). Mutagenic potential of ethanolic (Bagwe et al, 1990) and aqueous extracts (Polasa et al, 1993) of different brands of pan masala has also been reported.…”

Long-term carcinogenicity of pan masala in Swiss mice

“…In other studies, pan masala per se was reported to exhibit genotoxic and mutagenic properties in several short-term assays (Adhvaryu et al, 1989;Bagwe et al, 1990;Mukherjee and Giri, 1991;Polasa et al, 1993). Chronic feeding of pan masala was shown to impair liver function in rats and to affect the mouse germinal cells by inducing sperm-head abnormalities Sarma et al, 1992).…”

“…Habitual use of areca nut is causally associated with increased risk of human oral pre-cancer and cancer (Chin and Lee, 1970; IARC, 1985;Sinor et al, 1990). Catechu, another constituent of pan masala, was found to possess strong mutagenic (Stich et al, 1983) and clastogenic (Giri et al, 1987) activity, while lime is known to cause irritation and hyperplasia of the oral mucosa (Dunham et al, 1966).In other studies, pan masala per se was reported to exhibit genotoxic and mutagenic properties in several short-term assays (Adhvaryu et al, 1989;Bagwe et al, 1990;Mukherjee and Giri, 1991;Polasa et al, 1993). Chronic feeding of pan masala was shown to impair liver function in rats and to affect the mouse germinal cells by inducing sperm-head abnormalities Sarma et al, 1992).…”

Areca-nut extract modulates antigen-specific immunity and augments inflammation in ovalbumin-sensitized mice

“……”

Evaluation of carcinogenic/co-carcinogenic activity of a common chewing product, pan masala, in mouse skin, stomach and esophagus

“…Other histopathological observations revealed fatty and dysplastic changes, and hemangioma in the liver in the experimental groups. Bagwe et al, 1990;Mukherjee and Giri, 1991). Increased cytogenetic damage has been reported in peripheral-blood lymphocytes and exfoliated buccal mucosa of pan-masala consumers (Dave et al, 1991).…”

“…In keeping with the genotoxic properties of the individual constituents, an extract of pan masala was found to increase the frequencies of sister chromatid exchanges and chromosomal aberrations in mouse bone-marrow cells (Mukherjee and Giri, 1991) and Chinese hamster ovary cells (Adhvaryu et al, 1989). Mutagenic potential of ethanolic (Bagwe et al, 1990) and aqueous extracts (Polasa et al, 1993) of different brands of pan masala has also been reported.…”

Long-term carcinogenicity of pan masala in Swiss mice

“…In other studies, pan masala per se was reported to exhibit genotoxic and mutagenic properties in several short-term assays (Adhvaryu et al, 1989;Bagwe et al, 1990;Mukherjee and Giri, 1991;Polasa et al, 1993). Chronic feeding of pan masala was shown to impair liver function in rats and to affect the mouse germinal cells by inducing sperm-head abnormalities Sarma et al, 1992).…”

“…Habitual use of areca nut is causally associated with increased risk of human oral pre-cancer and cancer (Chin and Lee, 1970; IARC, 1985;Sinor et al, 1990). Catechu, another constituent of pan masala, was found to possess strong mutagenic (Stich et al, 1983) and clastogenic (Giri et al, 1987) activity, while lime is known to cause irritation and hyperplasia of the oral mucosa (Dunham et al, 1966).In other studies, pan masala per se was reported to exhibit genotoxic and mutagenic properties in several short-term assays (Adhvaryu et al, 1989;Bagwe et al, 1990;Mukherjee and Giri, 1991;Polasa et al, 1993). Chronic feeding of pan masala was shown to impair liver function in rats and to affect the mouse germinal cells by inducing sperm-head abnormalities Sarma et al, 1992).…”

Areca-nut extract modulates antigen-specific immunity and augments inflammation in ovalbumin-sensitized mice

“……”

Evaluation of carcinogenic/co-carcinogenic activity of a common chewing product, pan masala, in mouse skin, stomach and esophagus

“…Other histopathological observations revealed fatty and dysplastic changes, and hemangioma in the liver in the experimental groups. Bagwe et al, 1990;Mukherjee and Giri, 1991). Increased cytogenetic damage has been reported in peripheral-blood lymphocytes and exfoliated buccal mucosa of pan-masala consumers (Dave et al, 1991).…”

“…In keeping with the genotoxic properties of the individual constituents, an extract of pan masala was found to increase the frequencies of sister chromatid exchanges and chromosomal aberrations in mouse bone-marrow cells (Mukherjee and Giri, 1991) and Chinese hamster ovary cells (Adhvaryu et al, 1989). Mutagenic potential of ethanolic (Bagwe et al, 1990) and aqueous extracts (Polasa et al, 1993) of different brands of pan masala has also been reported.…”