2018
DOI: 10.1007/s11926-018-0724-6
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Abstract: Purpose of Review Premature activation of aging-associated molecular mechanisms is emerging as an important contributor to many diseases, including scleroderma. Among central regulators of the aging process are a group of histone deacetylases called sirtuins (SIRTs). Recent findings implicate these molecules as pathophysiological players in scleroderma skin and lung fibrosis. The goal of this article is to review recent studies on the involvement of SIRTs in scleroderma from the perspective of aging-related mo… Show more

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Cited by 23 publications
(21 citation statements)
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“…Interestingly, in this study, the expression of SIRT-1 was found reduced in SSc skin and its activation by resveratrol reversed the fibrotic response of fibroblasts (94). Emerging data corroborate this observation in SSc (95) and also suggests the role of SIRTs proteins in the development of cancer (96). Altogether, SIRTs proteins could contribute to SSc and cancer through different mechanisms: TGF-β signaling, mTOR pathway, oxidative stress and cellular senescence.…”
Section: Shared Mechanisms In Cancer and Systemic Sclerosissupporting
confidence: 55%
“…Interestingly, in this study, the expression of SIRT-1 was found reduced in SSc skin and its activation by resveratrol reversed the fibrotic response of fibroblasts (94). Emerging data corroborate this observation in SSc (95) and also suggests the role of SIRTs proteins in the development of cancer (96). Altogether, SIRTs proteins could contribute to SSc and cancer through different mechanisms: TGF-β signaling, mTOR pathway, oxidative stress and cellular senescence.…”
Section: Shared Mechanisms In Cancer and Systemic Sclerosissupporting
confidence: 55%
“…An age-associated CpG [42] in CYFIP1 , a regulator of translation and cytoskeletal dynamics, showed hypomethylation with underexpression in SSc blood [51]. It is interesting to note the variation in methylation levels at sites associated with aging, as premature activation of aging-associated molecular mechanisms is emerging as an important contributor to the autoimmune, vascular, and fibrotic pathogenesis of SSc [65]. Our findings, in conjunction with these reports, further lend support for the role of the innate immune response in the pathogenesis and/or progression of diseases such as SSc and a parallel between SSc and premature aging.…”
Section: Discussionmentioning
confidence: 99%
“…In contrast to a previous BM-MSC study [36], we demonstrated that SSc-ASC did not exhibit greater senescence than HD-ASC. Senescence is notably associated with decreased activity in sirtuins and is emerging as a pathophysiological contributor to scleroderma [37]; therefore, our results provide further evidence of the benefit of using adipose tissue as an MSC source for therapeutic purposes [38]…”
Section: Discussionmentioning
confidence: 74%