2016
DOI: 10.18632/aging.100975
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Abstract: SIRT6 is an important member of sirtuin family that represses inflammation, aging and DNA damage, three of which are causing factors for endothelial dysfunction. SIRT6 expression is decreased in atherosclerotic lesions from ApoE−/− mice and human patients. However, the role of SIRT6 in regulating vascular endothelial function and atherosclerosis is not well understood. Here we show that SIRT6 protects against endothelial dysfunction and atherosclerosis. Global and endothelium-specific SIRT6 knockout mice exhib… Show more

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Cited by 71 publications
(61 citation statements)
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References 70 publications
(108 reference statements)
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“…Since Sirt6 plays a pivotal role in inflammation [12, 15, 20, 29, 30], we speculate that inflammation may also contribute to renal dysfunction in Sirt6 KO mice. Therefore we examined the role of Sirt6 in the renal inflammatory processes.…”
Section: Resultsmentioning
confidence: 99%
“…Since Sirt6 plays a pivotal role in inflammation [12, 15, 20, 29, 30], we speculate that inflammation may also contribute to renal dysfunction in Sirt6 KO mice. Therefore we examined the role of Sirt6 in the renal inflammatory processes.…”
Section: Resultsmentioning
confidence: 99%
“…+/-/ApoE -/-mice fed a high-fat diet show impressive atherosclerotic lesion development, together with increased expression of the proinflammatory cytokine VCAM-1 (200).…”
Section: Sirt1 and Sirt6 In Cardiovascular Diseasementioning
confidence: 99%
“…In this regard, severe autophagy stimulated by high inflammation or oxidative stress leads to reduced collagen synthesis, fibrous cap thinning, plaque destabilization, restenosis, and acute coronary syndrome. Intriguingly, beside SIRT1, the link between SIRT6 and atherosclerotic plaque vulnerability has been unveiled only recently (16,44,110,200,218).…”
Section: Protective Role Of Sirt1 and Sirt6 In Atherosclerosismentioning
confidence: 99%
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