2017
DOI: 10.18632/aging.101214
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Abstract: Aging is associated with an increased incidence and prevalence of renal glomerular diseases. Sirtuin (Sirt) 6, a nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylase, has been shown to protect against multiple age-associated phenotypes; however it is unknown whether Sirt6 has a direct pathophysiologic role in the kidney. In the present study, we demonstrate that Sirt6 is expressed in the kidney and aging Sirt6-deficient mice exhibit renal hypertrophy with glomerular enlargement. Sirt6 deletion… Show more

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Cited by 49 publications
(44 citation statements)
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References 46 publications
(58 reference statements)
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“…The results of SP assay also obtained similar results. Recent study has shown that SIRT6 was closely related to the normal physiological function of the kidney [33]. Deletion of SIRT6 expression in mouse kidney could lead to progressive nephritis, glomerular hypertrophy, loss of podocyte structure and fibrosis.…”
Section: Discussionmentioning
confidence: 99%
“…The results of SP assay also obtained similar results. Recent study has shown that SIRT6 was closely related to the normal physiological function of the kidney [33]. Deletion of SIRT6 expression in mouse kidney could lead to progressive nephritis, glomerular hypertrophy, loss of podocyte structure and fibrosis.…”
Section: Discussionmentioning
confidence: 99%
“…Sirtuins are a family of NAD-dependent histone deacetylases that contain seven enzymatic members in mammals (Sirt1–7) with diverse cellular localizations and functions [ 31 , 32 ]. Sirt1, Sirt6 and Sirt7 mainly reside in the nucleus and regulate transcription by targeting transcription factors, co-factors or histones; Sirt3, Sirt4 and Sirt5 are predominantly localized within the mitochondria and may regulate mitochondrial energy metabolism; and Sirt2 is primarily found in the cytoplasm where it functions as a tubulin deacetylase.…”
Section: Discussionmentioning
confidence: 99%
“…All experimental procedures and use of animals were performed in accordance with the Association for Research in Vision and Ophthalmology Statement for the Use of Animals in Ophthalmic and Vision Research. C57BL/6J wild type (WT) mice were purchased from Jackson Laboratory (Bar Harbor, ME), Sirt6 KO and littermate control mice on a C57BL6/129svJ mixed background were generated as described previously [ 32 ], and all mice were maintained on a 12:12 light/dark cycle with food and water available ad libitum .…”
Section: Methodsmentioning
confidence: 99%
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“…Moreover, Liu et al [9] also found that podocyte-specific deletion of Sirt6 mice can cause development a slight albuminuria and podocyte injury at 12 month age, though no significant difference was observed in podocyte-specific deletion of Sirt6 mice compared to their control littermates when followed up to 9 months after birth. Consistently, global Sirt6 deletion in mice induces podocyte injury as evidenced by decreases in slit diaphragm proteins and foot process effacement, eventually leading to proteinuria [39]. These results suggest that Sirt1 and Sirt6 may be potential therapeutic targets for the treatment of patients with aging-related kidney disease.…”
Section: Nad + -Dependent Deacetylases On the Regulation Of Podocyte mentioning
confidence: 58%