2018
DOI: 10.18632/aging.101513
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Abstract: Corneal transparency, dependent on the integrity of epithelial cells, is essential for vision. Corneal epithelial damage is one of the most commonly observed ocular conditions and proper wound healing is necessary for corneal transparency. Sirt6, a histone deacetylase, has been shown to regulate many cellular events including aging and inflammation. However, its specific role in corneal epithelial wound healing remains unknown. Here we demonstrated that Sirt6 was expressed in corneal epithelial cells and its e… Show more

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Cited by 11 publications
(8 citation statements)
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References 36 publications
(8 reference statements)
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“…28 In addition, the Sirt6 and Notch signaling pathways have been reported to regulate podocyte injury and proteinuria, 29 whereas Sirt6 deficiency was found to impact corneal epithelial wound healing via Notch signaling. 30 Consistently, our study demonstrated that Sirt6 deficiency contributes toward EndMT induced by HG+PA via Notch1 signaling.…”
Section: Discussionsupporting
confidence: 85%
“…Corneal injury may result in susceptibility scarring, opacification, and loss of visual acuity. 6 , 35 Proper wound repair is vital for corneal epithelial integrity and transparency. 36 , 37 Our work provides new insights into the corneal wound healing process and identifies the IFNβ-MMP13 axis as a potential therapeutic target to promote corneal regeneration.…”
Section: Discussionmentioning
confidence: 99%
“…Similarly, the sirtuin activator resveratrol accelerates wound repair by increasing keratinocyte proliferation, while the sirtuin inhibitor sirtinol retards wound closure 27 . More recently, Hu et al 28 showed that Sirt6 KO mice display delayed and incomplete healing of the cornea after wounding. These reports suggest a beneficial role for sirtuin (specifically Sirt6) activation in wound healing.…”
Section: Discussionmentioning
confidence: 99%
“…Consistent with this finding, it is reported that SIRT6 deficiency causes delayed and incomplete wound healing in the corneal epithelial wound healing mouse model. At the molecular level, SIRT6 deficiency may result in the inhibition of Notch1 singling, thereby leading to dysregulation of corneal epithelial homeostasis and associated excessive inflammation in the corneal stroma 282 …”
Section: Human Diseasesmentioning
confidence: 99%
“…An important indication of histone modification involvement in corneal repair was when suberoylanilide hydroxamic acid (SAHA) showed an inhibitory effect on corneal neovascularization via repressing histone deacetylase-mediated hemangiogenesis and inflammation pathways [ 11 ]. Furthermore, deficiency of a histone deacetylase Sirt6 delayed corneal epithelial wound closure which resulted in excessive inflammation in the corneal stroma [ 12 ]. MicroRNA (miRNA) is another epigenetic modulator whose changes in expression levels affect CEWH in mice [ 13 ].…”
Section: Introductionmentioning
confidence: 99%